1001419-35-7

Basic information

• Product Name: TERT-BUTYL 4-(BROMOMETHYL)THIAZOL-2-YLCARBAMATE
• Synonyms: TERT-BUTYL 4-(BROMOMETHYL)THIAZOL-2-YLCARBAMATE
• CAS NO: 1001419-35-7
• Molecular Formula: C9H13BrN2O2S
• Molecular Weight: 293.18072
• Mol File: 1001419-35-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Density: 1.537±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.97±0.70(Predicted)
• CAS DataBase Reference: TERT-BUTYL 4-(BROMOMETHYL)THIAZOL-2-YLCARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 4-(BROMOMETHYL)THIAZOL-2-YLCARBAMATE(1001419-35-7)
• EPA Substance Registry System: TERT-BUTYL 4-(BROMOMETHYL)THIAZOL-2-YLCARBAMATE(1001419-35-7)

Safety Data

• Hazardous Substances Data: 1001419-35-7(Hazardous Substances Data)

Usage

General Description

Tert-Butyl 4-(bromomethyl)thiazol-2-ylcarbamate is a chemical compound with the molecular formula C10H15BrN2O2S. It is a thiazole derivative used in the synthesis of pharmaceutical and agricultural products. The tert-butyl group and bromomethyl group in the molecular structure increase the compound's stability and reactivity, making it useful in various chemical reactions. TERT-BUTYL 4-(BROMOMETHYL)THIAZOL-2-YLCARBAMATE may have applications in drug development and as a precursor for the synthesis of other organic compounds. It is important to handle and use this chemical with caution due to its potential hazards.

Upstream product

• 189512-01-4 ethyl 2-[(tert-butoxycarbonyl)amino]thiazole-4-carboxylate 
• 494769-44-7 (4-hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 816-39-7 1,3-dibromoroacetone 
• 268551-65-1 tert-butyl carbamothioylcarbamate 
• 1337606-64-0 C₁₀H₁₆N₂O₅S₂ 

Relevant articles and documents

12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents

The synthesis and biological evaluation of a series of 12,13-aziridinyl epothilone B analogues is described. These compounds were accessed by a practical, general process that involved a 12,13-olefinic methyl ketone as a starting material obtained by ozonolytic cleavage of epothilone B followed by tungsten-induced deoxygenation of the epoxide moiety. The attachment of the aziridine structural motif was achieved by application of the Ess-Kürti-Falck aziridination, while the heterocyclic side chains were introduced via stereoselective phosphonate-based olefinations. In order to ensure high (E) selectivities for the latter reaction for electron-rich heterocycles, it became necessary to develop and apply an unprecedented modification of the venerable Horner-Wadsworth-Emmons reaction, employing 2-fluoroethoxyphosphonates that may prove to be of general value in organic synthesis. These studies resulted in the discovery of some of the most potent epothilones reported to date. Equipped with functional groups to accommodate modern drug delivery technologies, some of these compounds exhibited picomolar potencies that qualify them as payloads for antibody drug conjugates (ADCs), while a number of them revealed impressive activities against drug resistant human cancer cells, making them desirable for potential medical applications.

THIOBENZOIMIDAZOLE AS FUNGICIDES

The present invention relates to 2-thiobenzimidazoles of formula (I) which are of use as fungicides.

EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES THEREOF

In one aspect, the present disclosure provides epothilone analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.