Synonyms:Z-D-aThr(t-Bu)-OMe
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All total 2 Articles be foundThe present invention relates to 1,2,4-oxadiazole compounds of formula (I) and their use to inhibit the programmed cell death (PD1) signaling pathway and/or for treatment of disorders by inhibiting an immunosuppressive signal induced by PD-1,PD-L1 or PD-L2.
N-Z-O-tert-butyl-L-threonine
methyl iodide
N-Carbobenzoxy-O-tert.-butyl-L-threonin-methylester
| Conditions | Yield |
|---|---|
|
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 3h;
|
6.4 g |
N-carbobenzyloxy-D-allo-threonine methyl ester
isobutene
Z-D-aThr(t-Bu)-OMe
| Conditions | Yield |
|---|---|
|
With
sulfuric acid;
In
dichloromethane;
at 20 ℃;
for 120h;
|
68% |
isobutene
Z-DL-Thr(t-Bu)-OMe
| Conditions | Yield |
|---|---|
|
With
sulfuric acid;
In
dichloromethane;
at 20 ℃;
for 120h;
|
isobutene
Z-DL-aThr(t-Bu)-OMe
| Conditions | Yield |
|---|---|
|
With
sulfuric acid;
In
dichloromethane;
at 20 ℃;
for 120h;
|
benzyl chloroformate
Z-DL-Thr(t-Bu)-OMe
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1: triethylamine / CHCl3 / 12 h / 0 °C
2: conc. H2SO4 / CH2Cl2 / 120 h / 20 °C
With
sulfuric acid; triethylamine;
In
dichloromethane; chloroform;
|
N-Carbobenzoxy-O-tert.-butyl-L-threonin-methylester
| Conditions | Yield |
|---|---|
|
Z-Thr(tBu), Diazomethan;
|
Z-D-aThr(t-Bu)-OMe
Z-D-aThr(t-Bu)-OH
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
In
1,4-dioxane; water;
at 20 ℃;
for 4h;
|
85% |
N-Carbobenzoxy-O-tert.-butyl-L-threonin-methylester
| Conditions | Yield |
|---|---|
|
With
methanol; hydrazine hydrate;
at 20 ℃;
for 12h;
|
5.5 g |
Z-DL-Thr(t-Bu)-OMe
Z-DL-Thr(t-Bu)-OH
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
In
1,4-dioxane; water;
at 20 ℃;
for 4h;
|
Z-DL-aThr(t-Bu)-OMe
Z-DL-aThr(t-Bu)-OH
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
In
1,4-dioxane; water;
at 20 ℃;
for 4h;
|
N-Z-O-tert-butyl-L-threonine
methyl iodide
N-carbobenzyloxy-D-allo-threonine methyl ester
isobutene
Z-DL-Thr-OMe
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