100165-14-8

Basic information

• Product Name: 3-dodecyloxypropane-1,2-diol
• Synonyms: 3-dodecyloxypropane-1,2-diol
• CAS NO: 100165-14-8
• Molecular Weight: 260.417
• Mol File: 100165-14-8.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 3-dodecyloxypropane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-dodecyloxypropane-1,2-diol(100165-14-8)
• EPA Substance Registry System: 3-dodecyloxypropane-1,2-diol(100165-14-8)

Safety Data

• Hazardous Substances Data: 100165-14-8(Hazardous Substances Data)

Upstream product

• 6145-80-8 1-(allyloxy)dodecane 
• 112-54-9 Dodecanal 
• 56-81-5 glycerol 
• 112-53-8 1-dodecyl alcohol 
• 931-40-8 4-hydroxymethyl-1,3-dioxolan-2-one 
• 111-82-0 methyl n-dodecanoate 
• 40738-26-9 rac-1-monolauroylglycerol 
• 143-07-7 lauric acid 
• 143-15-7 1-dodecylbromide 
• 2461-18-9 dodecyl glycidyl ether 
• 151-21-3 sodium dodecyl-sulfate 
• 117088-99-0 acetic acid 2-acetoxy-1-dodecyloxymethyl-ethyl ester 
• 117089-03-9 2,2-dimethyl-4-dodecyloxymethyl-1,3-dioxolane 
• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 

Downstream Products

• 17677-16-6 3-dodecyloxy-1-triphenylmethoxy-2-propanol 
• 99651-71-5 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-dodecyloxymethyl-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-ethyl ester 
• 106881-92-9 C₄₁H₅₂O₃ 
• 70641-54-2 C₂₇H₅₀NO₆P 
• 106881-97-4 Phosphoric acid 2-benzyloxy-3-dodecyloxy-propyl ester 2-bromo-ethyl ester 
• 73073-46-8 3-(dodecyloxy)-2-hydroxypropyl 2-(trimethylammonio)ethyl phosphate 
• 125001-94-7 2-(benzyloxy)-3-(dodecyloxy)propan-1-ol 

Relevant articles and documents

Design, synthesis and cytotoxicity of chimeric erlotinib-alkylphospholipid hybrids

Two series of erlotinib-alkylphospholipid hybrids were prepared and evaluated for their antiproliferative activities against a panel of four cell lines representing lung, breast, liver and skin cancers using erlotinib and miltefosine as reference standards. Amide analogs elicited more enhanced cytotoxic activity than analogous esters. Amide derivatives 8d and 8e exhibited promising broad-spectrum antiproliferative activity and higher efficacy than reference erlotinib and miltefosine. Their cellular GI50 values was in the ranges of 24.7–46.9 μM and 26.8–43.1 μM for 8e and 8d respectively. Assay results of the inhibitory activity of the prepared compounds on EGFR kinase reaction and Akt phosphorylation in conjugation with statistical correlation analysis indicated that other mechanisms might contribute to their elicited cytotoxicities. In addition, statistical correlation analysis revealed that mechanisms of elicited cytotoxicities for amide series might be different from ester series. In addition, correlation analysis indicated variations in the mechanisms according to the types of cell line.

METHODS FOR PREPARING ALKYLGLYCERYL ETHERS

The present invention relates to a method for manufacturing alkyl glyceryl ether by conducting reaction of alkyl glycidyl ether and water in the presence of a solvent and a catalyst to obtain alkyl glyceryl ether, wherein the solvent comprises glycol ethers, and the catalyst comprises an alkali metal salt of a carboxylic acid. The method of the present invention does not require use of chemicals other than the solvent and the catalyst, so that the production cost is low and cost-effective.COPYRIGHT KIPO 2018

METHOD FOR PREPARING GLYCEROL ETHER AND GLYCOL ETHER

The present invention concerns a method for preparing glycerol ether or glycol ether comprising the reaction of a compound of formula (II) with a compound of formula (III) in the presence of a heterogeneous acid catalyst of formulas (II) and (III).