10017-44-4

Basic information

• Product Name: L-Carnitine hydrochloride
• Synonyms: (S)-Carnitine hydrochloride;1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, chloride, (2S)- (9CI);1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, chloride, (S)-;d-Carnitine chloride;1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, chloride, (2S)-;3-carboxy-2-hydroxy-n,n,n-trimethyl-, chloride, (s)-1-propanaminiu;S-Cartininehydrochloride;L-Carnitine hydrochloride
• CAS NO: 10017-44-4
• Molecular Formula: C₇H₁₆NO₃*Cl
• Molecular Weight: 197.66
• EINECS: 207-309-1
• Product Categories: Nutritional Supplements
• Mol File: 10017-44-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 135-137 °C
• Appearance: /
• Storage Temp.: Store at 0°C
• CAS DataBase Reference: L-Carnitine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Carnitine hydrochloride(10017-44-4)
• EPA Substance Registry System: L-Carnitine hydrochloride(10017-44-4)

Safety Data

• Hazardous Substances Data: 10017-44-4(Hazardous Substances Data)

Usage

General Description

L-Carnitine hydrochloride, also known as levocarnitine, is a naturally occurring amino acid that plays a crucial role in the metabolism of fats within the body. L-Carnitine hydrochloride is involved in the transportation of long-chain fatty acids into the mitochondria, where they are ultimately converted into energy through the process of beta-oxidation. L-Carnitine hydrochloride has been studied for its potential benefits in enhancing athletic performance, improving energy production, and supporting heart health. It is commonly used as a dietary supplement to address conditions such as carnitine deficiency, muscle weakness, and fatigue. Additionally, L-Carnitine hydrochloride is known to have antioxidant properties, which may contribute to its protective effects on cells and tissues.

InChI:InChI=1/C7H15NO3.ClH/c1-8(2,3)5-6(9)4-7(10)11;/h6,9H,4-5H2,1-3H3;1H/t6-;/m0./s1

Upstream product

• 32807-28-6 Methyl 4-chloroacetoacetate 
• 33620-52-9 S-carnitine methyl ester hydrobromide 
• 541-15-1 L-carnitine 
• 33620-52-9 C₈H₁₈NO₃⁽¹⁺⁾*BrH 
• 2788-28-5 (2R)-(-)-3-cyano-2-hydroxypropyltrimethylammonium chloride 
• 107799-29-1 (+)-(3S,2'S)-ethyl 3-<(2-methoxy-2-phenylacetyl)oxy>-4-(triethylammonio)butanoate iodide 

Downstream Products

• 1329552-68-2 ketoprofen-glycolic acid-l-carnitine 
• 1329552-65-9 C₂₈H₃₄NO₅⁽¹⁺⁾ 
• 2504-11-2 acetyl-D,L-carnitine*HCl 
• 76474-64-1 (R)-acetylthiocarnitine 
• 161886-59-5 (S)-carnitine mesylate isobutyl ester mesylate 
• 161886-60-8 (S)-carnitine mesylate mesylate 
• 541-15-1 L-carnitine 
• 3040-38-8 Acetyl-L-carnitine 

Relevant articles and documents

An efficient synthesis of (R)-carnitine

An efficient synthesis of (R)-carnitine hydrochloride is described. The starting material is obtained by microbial resolution of (RS)-2,3-dichloro-1-propanol.

Lipase-catalyzed enantiomer separation of 3-hydroxy-4-(tosyloxy) butanenitrile: Synthesis of (R)-GABOB (=(3R)-4-amino-3-hydroxybutanoic acid) and (R)-carnitine hydrochloride (= (2R)-3-carboxy-2-hydroxy-N,N,N-trimethylpropan- 1-aminium chloride)

Enzymatic resolution of racemic 3-hydroxy-4-(tosyloxy)butanenitrile ((±)-5) by using various lipases in different solvents were studied. The obtained optically pure (3R)-3-(acetyloxy)-4-(tosyloxy)-butanenitrile ((R)-6), upon treatment with aqueous ammonia followed by cone. HCl solution, provided (R)-GABOB (=(3R)-4-amino-3-hydroxybutanoic acid; (R)-1). Similarly, reaction of (R)-6 with aqueous trimethylamine solution followed by cone. HCl solution provided (R)-carnitine hydrochloride (=(2R)-3-carboxy-2-hydroxy-N,N,N- trimethylpropan-1-aminium chloride; (R)-2·HCl) in an expeditious manner.

ENANTIOSELECTIVE HYDROGENATION REACTIONS WITH A FULL SET OF PREFORMED AND PREPARED IN SITU CHIRAL DIPHOSPHINE-RUTHENIUM (II) CATALYSTS

The new class of 2-methylallyl ruthenium chiral diphosphines 1 are efficient in asymmetric hydrogenation of α,β unsaturated acids and allylic alcohols.The related chiral halogen-containing ruthenium catalysts 2 are prepared from 1 or in situ from (COD)Ru(η3-(CH2)2CHCH3)2 by ligand exchange with the chelating diphosphine followed by protonation (HX) in acetone.This procedure allows rapid screening of chiral phosphines, such as Diop, Chiraphos, Cbd, Bppm, Binap, β-glucophos, Biphemp, MeO-Biphep, Me-Duphos, in ruthenium mediated hydrogenations of prochiral substrates.A high efficiency is displayed by Ru-catalysts having atropisomeric ligands (e.e. up to 99percent), and a C2 symmetric bis(phospholane) has also emerged as a valuable ligand (Me-Duphos, e.e. up to 87percent not optimized).Asymmetric hydrogenation of β-keto esters can be conducted under quite mild conditions (4 atm. of H2, 50 deg C, e.e. up to 99percent), β-keto esters having a disubstituted double bond are also hydrogenated chemoselectively to unsaturated chiral alcohols under controlled conditions with excellent optical purities.