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1001917-62-9

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1001917-62-9 Usage

General Description

The chemical compound 2-[(dimethylamino)sulfonyl]acetic acid methyl ester is a sulfonamide derivative that is commonly used as a reagent in organic synthesis and pharmaceutical research. It is a white crystalline solid with a molecular formula of C6H13NO4S and a molecular weight of 191.23 g/mol. 2-[(dimethylamino)sulfonyl]Acetic acid methyl ester has been found to exhibit various biological activities, including anti-inflammatory, antibacterial, and antifungal properties. It is also used as a building block in the synthesis of pharmaceuticals and agrochemicals. Additionally, it is known for its potential as a modifying reagent in the development of new drugs. Overall, 2-[(dimethylamino)sulfonyl]acetic acid methyl ester has a wide range of applications in the field of chemistry and medicine.

Check Digit Verification of cas no

The CAS Registry Mumber 1001917-62-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,1,9,1 and 7 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1001917-62:
(9*1)+(8*0)+(7*0)+(6*1)+(5*9)+(4*1)+(3*7)+(2*6)+(1*2)=99
99 % 10 = 9
So 1001917-62-9 is a valid CAS Registry Number.

1001917-62-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 2-(N,N-dimethylsulfamoyl)acetate

1.2 Other means of identification

Product number -
Other names methyl [(dimethylamino)sulfonyl]acetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1001917-62-9 SDS

1001917-62-9Downstream Products

1001917-62-9Relevant articles and documents

ANTIVIRAL PYRIDOPYRAZINEDIONE COMPOUNDS

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Paragraph 0587-0588, (2020/04/09)

The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5] cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met

Northrup, Alan B.,Katcher, Matthew H.,Altman, Michael D.,Chenard, Melissa,Daniels, Matthew H.,Deshmukh, Sujal V.,Falcone, Danielle,Guerin, David J.,Hatch, Harold,Li, Chaomin,Lu, Wei,Lutterbach, Bart,Allison, Timothy J.,Patel, Sangita B.,Reilly, John F.,Reutershan, Michael,Rickert, Keith W.,Rosenstein, Craig,Soisson, Stephen M.,Szewczak, Alexander A.,Walker, Deborah,Wilson, Kevin,Young, Jonathan R.,Pan, Bo-Sheng,Dinsmore, Christopher J.

, p. 2294 - 2310 (2013/06/04)

This report documents the first example of a specific inhibitor of protein kinases with preferential binding to the activated kinase conformation: 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one 11r (MK-8033), a dual c-Met/Ron inhibitor under investigation as a treatment for cancer. The design of 11r was based on the desire to reduce time-dependent inhibition of CYP3A4 (TDI) by members of this structural class. A novel two-step protocol for the synthesis of benzylic sulfonamides was developed to access 11r and analogues. We provide a rationale for the observed selectivity based on X-ray crystallographic evidence and discuss selectivity trends with additional examples. Importantly, 11r provides full inhibition of tumor growth in a c-Met amplified (GTL-16) subcutaneous tumor xenograft model and may have an advantage over inactive form kinase inhibitors due to equal potency against a panel of oncogenic activating mutations of c-Met in contrast to c-Met inhibitors without preferential binding to the active kinase conformation.

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