1002-79-5

Basic information

• Product Name: (10E,12Z)-10,12-octadecadienoic acid methyl ester
• CAS NO: 1002-79-5
• Molecular Weight: 294.478
• Mol File: 1002-79-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 136-142 °C(Press: 0.01 Torr)
• Density: 0.884±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (10E,12Z)-10,12-octadecadienoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (10E,12Z)-10,12-octadecadienoic acid methyl ester(1002-79-5)
• EPA Substance Registry System: (10E,12Z)-10,12-octadecadienoic acid methyl ester(1002-79-5)

Safety Data

• Hazardous Substances Data: 1002-79-5(Hazardous Substances Data)

Usage

Uses

Conjugated Linoleic Acid Methyl Ester is the methyl ester derivative of Conjugated Linoleic Acid (C685000); a compound that has reported to exhibit anticarcinogenic activity. Also a potent antioxidant.

Upstream product

• 16666-79-8 hexylidenetriphenylphosphoran 
• 63024-87-3 (E)-11-Formyl-10-undecensaeure-methylester 
• 186581-53-3 diazomethane 
• 60-33-3 linoleic acid 
• 67-56-1 methanol 
• 2462-85-3 linoleic acid methyl ester 
• 112-63-0 Methyl linoleate 
• 544-70-7 cis-9,trans-11-octadecadienoic acid 
• 1072-36-2 trans-10,cis-12-octadecadienoic acid 
• 141-24-2 methyl ricinoleate 

Relevant articles and documents

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Transformation of Methyl Linoleate to its Conjugated Derivatives with Simple Pd(OAc)2/Lewis Acid Catalyst

With the rapid depletion of fossil resources, the exploitation of biomass to partly replace fossil resources as the source of carbon in the chemical industry constitutes a promising alternative for the near future. This work introduces catalytic transformation of vegetable oil, i.e., methyl linoleate, to its conjugated esters by a simple Pd(OAc)2/Sc(OTf)3 catalyst, which has extensive applications in industry. It was found that adding non-redox metal ions like Sc(III) to a simple Pd(OAc)2 catalyst can effectively improve its isomerization activity in toluene/t-BuOH solvent, whereas Pd(OAc)2 alone is inactive. Preliminary mechanistic investigations together with previous studies suggested that the in situ-generated heterobimetallic Pd(II)/Sc(III) dimer serves as the key species for methyl linoleate isomerization, and the reaction proceeds by [1,3]-hydrogen shift mechanism involving a formal Pd(II)/Pd(IV) cycle.

Absorption Kinetics of the Main Conjugated Linoleic Acid Isomers in Commercial-Rich Oil after Oral Administration in Rats

This study aimed to assess the oral absorption and plasma kinetics of two main isomers contained in commercial conjugated linoleic acid (CLA)-rich oil (Tonalin TG-80), rumenic acid (RA), and C18:2 trans-10, cis-12. The isomer plasma disposition after the single oral dose of 3000 mg of Tonalin TG-80/kg, containing 1200 mg/kg of each isomer, was studied in rats. The isomer plasma concentrations were determined by gas chromatography with flame ionization detection. The plasma kinetics showed rapid oral absorption of RA and C18:2 trans-10, cis-12 (t1/2a 0.34 ± 0.09 and 0.53 ± 0.01 h) and slow elimination (t1/2β 25.68 ± 3.29 and 18.12 ± 1.71 h); the maximal isomer plasma concentrations (Cmax) of 8.48 ± 0.98 and 7.67 ± 0.80 μg mL-1, respectively, were estimated at 2.08 ± 0.14 and 2.26 ± 0.11 h. Our results from a preclinical kinetic study in rats help to design future studies in humans for evaluating the CLA isomer dose-response.

Chemoenzymatic synthesis of conjugated linoleic acid

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