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100202-78-6

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100202-78-6 Usage

General Description

2-(Bromomethyl)-6-fluoropyridine is a chemical compound comprising bromine, fluorine, carbon and nitrogen atoms. It falls under the category of Organobromides and Organofluorides, which are organic compounds containing carbon-bromine and carbon-fluorine bonds respectively. Due to the presence of a pyridine ring, it also belongs to the class of heterocyclic aromatic compounds. This chemical is used primarily as an intermediate in organic synthesis due to its reactivity. Due to the presence of the bromide and fluoride groups, this compound may be involved in various chemical reactions to form more complex structures. As with all chemical compounds, the use, handling, storage, and disposal of 2-(Bromomethyl)-6-fluoropyridine should be carried out in accordance with appropriate safety procedures.

Check Digit Verification of cas no

The CAS Registry Mumber 100202-78-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,2,0 and 2 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 100202-78:
(8*1)+(7*0)+(6*0)+(5*2)+(4*0)+(3*2)+(2*7)+(1*8)=46
46 % 10 = 6
So 100202-78-6 is a valid CAS Registry Number.

100202-78-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(Bromomethyl)-6-fluoropyridine

1.2 Other means of identification

Product number -
Other names 6-(bromomethyl)-2-fluoropyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100202-78-6 SDS

100202-78-6Relevant articles and documents

In vitro and in vivo evaluation of fluorinated indanone derivatives as potential positron emission tomography agents for the imaging of monoamine oxidase B in the brain

Duki?-Stefanovi?, Sladjana,Hang Lai, Thu,Toussaint, Magali,Clau?, Oliver,Jevti?, Ivana I.,Penji?evi?, Jelena Z.,Andri?, Deana,Ludwig, Friedrich-Alexander,Gündel, Daniel,Deuther-Conrad, Winnie,Kosti?-Raja?i?, Sladjana V.,Brust, Peter,Teodoro, Rodrigo

, (2021)

Monoamine oxidases (MAOs) play a key role in the metabolism of major monoamine neurotransmitters. In particular, the upregulation of MAO-B in Parkinson's disease, Alzheimer's disease and cancer augmented the development of selective MAO-B inhibitors for d

Targeting cyclic nucleotide phosphodiesterase 5 (PDE5) in brain: Toward the development of a PET radioligand labeled with fluorine-18

Wenzel, Barbara,Liu, Jianrong,Dukic-Stefanovic, Sladjana,Deuther-Conrad, Winnie,Teodoro, Rodrigo,Ludwig, Friedrich-Alexander,Chezal, Jean-Michel,Moreau, Emmanuel,Brust, Peter,Maisonial-Besset, Aurelie

, p. 346 - 362 (2019)

With the aim to develop a specific radioligand for imaging the cyclic nucleotide phosphodiesterase 5 (PDE5) in brain by positron emission tomography (PET), seven new fluorinated inhibitors (3–9) were synthesized on the basis of a quinoline core. The inhibitory activity for PDE5 together with a panel of other PDEs was determined in vitro and two derivatives were selected for IC50 value determination. The most promising compound 7 (IC50 = 5.92 nM for PDE5A), containing a 3-fluoroazetidine moiety, was further radiolabeled by aliphatic nucleophilic substitution of two different leaving groups (nosylate and tosylate) using [18F]fluoride. The use of the nosylate precursor and tetra-n-butyl ammonium [18F]fluoride ([18F]TBAF) in 3-methyl-3-pentanol combined with the addition of a small amount of water proved to be the best radiolabeling conditions achieving a RCY of 4.9 ± 1.5% in an automated procedure. Preliminary biological investigations in vitro and in vivo were performed to characterize this new PDE5 radioligand. Metabolism studies of [18F]7 in mice revealed a fast metabolic degradation with the formation of radiometabolites which have been detected in the brain.

Cap-dependent protease inhibitor

-

Paragraph 0059-0062, (2021/06/09)

The invention relates to a compound with cap-dependent endonuclease inhibitory activity and application of the compound in the aspect of influenza treatment.

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