10022-80-7

Basic information

• Product Name: 3H-Pyrido[3,4-b]indole, 4,9-dihydro-1-(phenylmethyl)-
• Synonyms: 3H-Pyrido[3,4-b]indole,4,9-dihydro-1-(phenylmethyl);1-Benzyl-3,4-dihydro-9H-pyrido<3.4-b>indol
• CAS NO: 10022-80-7
• Molecular Formula: C18H16N2
• Molecular Weight: 260.338
• Mol File: 10022-80-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3H-Pyrido[3,4-b]indole, 4,9-dihydro-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Pyrido[3,4-b]indole, 4,9-dihydro-1-(phenylmethyl)-(10022-80-7)
• EPA Substance Registry System: 3H-Pyrido[3,4-b]indole, 4,9-dihydro-1-(phenylmethyl)-(10022-80-7)

Safety Data

• Hazardous Substances Data: 10022-80-7(Hazardous Substances Data)

Upstream product

• 103-82-2 phenylacetic acid 
• 61-54-1 tryptamine 
• 19462-24-9 N-phenylacetyltryptamine 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 1198364-43-0 C₃₅H₄₀N₂O₂ 
• 181492-01-3 (R)-1-benzyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole 
• 99545-51-4 (S)-1-benzyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole 
• 91751-37-0 1-Phenyl-2,6,7,12-tetrahydro-3H-indolo[2,3-a]quinolizin-4-one 
• 3851-30-7 1-benzyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole 

Relevant articles and documents

1-Benzyl-1,2,3,4-Tetrahydro-β-Carboline as Channel Blocker of N-Methyl-d-Aspartate Receptors

N-methyl-d-aspartate (NMDA) receptors belong to the family of ligand-gated ion channels and are important for synaptic plasticity and memory function. The NMDA receptor consists of a voltage-dependent channel permeable to Ca2+ and Na+/sup

Palladium asymmetric reduction of β-carboline imines mediated by chiral auxiliaries assisted by microwave irradiation

An alternative synthetic approach for the introduction of chirality in β-carboline moiety through in situ reduction of N-acyliminium ion intermediates generated from imine 2 and chloroformate of 8-phenylmenthyl as chiral auxiliary was achieved. The method applied microwave-assisted irradiation and used PdCl2/Et3SiH protocol as a mild reducing agent, which decreased reaction times to minutes when compared to the conventional thermal reactions. The diastereoselectivity (4-12:1) of the reduction produced R-amines, which were assigned after chiral auxiliary removal and spectroscopic data compared to products obtained from Noyori asymmetric hydrogenation catalyst.

Synthesis, crystal structure and biological activity of β-carboline based selective CDK4-cyclin D1 inhibitors

The design, synthesis and biological activity of a series of non-planar dihydro-β-carboline and β-carboline-based derivatives of the toxic anticancer agent fascaplysin is presented. We show these compounds to be selective inhibitors of CDK4 over CDK2 with an IC50 (CDK4-cyclin D1) = 11 mol for the best compound in the series 4d. The crystallographic analysis of some of the compounds synthesised (3b/d and 4a-d) was carried out, in an effort to estimate the structural similarities between the designed inhibitors and the model compound fascaplysin. The Royal Society of Chemistry.