Welcome to LookChem.com Sign In|Join Free

CAS

  • or

100241-92-7

Post Buying Request

100241-92-7 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

100241-92-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 100241-92-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,2,4 and 1 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 100241-92:
(8*1)+(7*0)+(6*0)+(5*2)+(4*4)+(3*1)+(2*9)+(1*2)=57
57 % 10 = 7
So 100241-92-7 is a valid CAS Registry Number.

100241-92-7Relevant articles and documents

AMPA receptor agonists: Synthesis, protolytic properties, and pharmacology of 3-isothiazolol bioisosteres of glutamic acid

Matzen, Lisa,Engesgaard, Anne,Ebert, Bjarke,Didriksen, Michael,Fr?lund, Bente,Krogsgaard-Larsen, Povl,Jaroszewski, Jerzy W.

, p. 520 - 527 (2007/10/03)

A number of 3-isothiazolol bioisosteres of glutamic acid (1) and analogs of the AMPA receptor agonist, (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4- yl)propionic acid (AMPA, 2a), including (RS)-2-amino-3-(3-hydroxy-5- methylisothiazol-4-yl)propionic acid (thio-AMPA, 2b), were synthesized. Comparative in vitro pharmacological studies on this series of 3-isothiazolol and the corresponding 3-isoxazolol amino acids were performed using a series of receptor binding assays (IC50 values) and the electrophysiological rat cortical slice model (EC50 values). Whereas 2a (IC50 = 0.04 ± 0.005 μM, EC50 = 3.5 ± 0.2 μM) is markedly more potent than the tert-butyl analog ATPA (3a) (IC50 = 2.1 ± 0.16 μM, EC50 = 34 ± 2.4 μM) in [3H]AMPA binding and electrophysiological studies, 2b (IC50 = 1.8 ± 0.13 μM, EC50 = 15.0 ± 2.4 μM) was approximately equipotent with thio-ATPA (3b) (IC50 = 0.63 ± 0.07 μM, EC50 = 14 ± 1.3 μM). (RS)-2-Amino-3-(3- hydroxyisoxazol-5-yl)propionic acid (HIBO, 4a) was approximately equipotent with its thio analog 4b, whereas 4-Br-HIBO (5a) (IC50 = 0.65 ± 0.12 μM, EC50 = 22 ± 0.6 μM) turned out to be much more potent than the corresponding 3-isothiazolol 5b (IC50 = 17 ± 2.2 μM, EC50 = 500 ± 23 μM), 2b (ED50 = 130 μmol/kg) was more potent than 2a (220 μmol/kg) as a convulsant after subcutaneous administration in mice. The protolytic properties of 2a,b-4a,b were determined using 13C NMR spectroscopy. For each pair of compounds, the α-amino acid groups showed similar protolytic properties, whereas the 3-isoxazolol moieties typically showed pK(a) values 2 units lower than those of the 3-isothiazolols. Accordingly, calculations of ionic species distributions revealed pronounced differences between 3- isoxazolol and 3-isothiazolol amino acids. No simple correlation between activity as AMPA agonists in vitro and pK(a) values of these compounds was apparent. On the other hand, the relative potencies of AMPA (2a) and thio- AMPA (2b) in vitro and in vivo may reflect that these compounds predominantly penetrate the blood-brain barrier as net uncharged diprotonated ionic species.

Synthesis, GABA agonist activity and effects on GABA and diazepam binding of some N-substituted analogues of GABA

Falch,Krogsgaard-Larsen,Jacobsen,et al.

, p. 447 - 453 (2007/10/02)

-

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 100241-92-7