100242-07-7

Basic information

• Product Name: methyl 5-amino-4-oxo-6-phenylhexanoate hydrochloride
• Synonyms: methyl 5-amino-4-oxo-6-phenylhexanoate hydrochloride
• CAS NO: 100242-07-7
• Molecular Weight: 271.744
• Mol File: 100242-07-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 5-amino-4-oxo-6-phenylhexanoate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-amino-4-oxo-6-phenylhexanoate hydrochloride(100242-07-7)
• EPA Substance Registry System: methyl 5-amino-4-oxo-6-phenylhexanoate hydrochloride(100242-07-7)

Safety Data

• Hazardous Substances Data: 100242-07-7(Hazardous Substances Data)

Upstream product

• 83084-67-7 2-Phenyl-4-benzyl-4-β-carbomethoxypropionyloxazolone 
• 83148-55-4 δ-(benzoylamino)-γ-oxobenzenehexanoic acid 
• 5874-61-3 4-benzyl-2-phenyl-2-oxazolin-5-one 
• 77982-73-1 (R,S)-5-benzoylamino-4-oxo-6-phenylhexanoic acid methyl ester 
• 67-56-1 methanol 
• 77982-74-2 δ-amino-γ-oxobenzenehexanoic acid hydrochloride 

Downstream Products

• 83450-73-1 (S)-1-((S)-5-Decanoylamino-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid 
• 83509-06-2 (S)-1-((S)-5-Octanoylamino-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid 
• 83084-86-0 5-n-butyloxycarbonylamino-4-oxo-6-phenylhexanoyl-L-proline 
• 83084-94-0 (S)-1-((S)-5-Hexanoylamino-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid 
• 83450-71-9 5-Octanoylamino-4-oxo-6-phenyl-hexanoic acid methyl ester 
• 83450-63-9 methyl 5-<(n-butyloxycarbonyl)amino>-4-oxo-6-phenylhexanoate 
• 100242-09-9 Boc-Tyr-D-Ala-Phe-CH₂-CH₂-CO-OMe 
• 83450-72-0 5-Decanoylamino-4-oxo-6-phenyl-hexanoic acid methyl ester 
• 83450-70-8 5-Hexanoylamino-4-oxo-6-phenyl-hexanoic acid methyl ester 

Relevant articles and documents

Dehydro keto methylene and keto methylene analogues of substance P. Synthesis and biological activity

The synthesis of dehydro keto methylene and keto methylene analogues of substance P using classical peptide synthesis is described. The following analogues were prepared: [pGlu6,Gly9ψ(COCH2)(RS)Leu10]SP6-11

Derivatives of the potent angiotensin converting enzyme inhibotor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline: Effect of changes at positions 2 and 5 of the hexanoic acid portion

Several derivatives of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline (1) were synthesized and tested for converting enzyme inhibition activity and blood pressure lowering effects in rats. One compound, 5(S)-benzamido-2(R)-methyl-4-oxo-6-phenylhexanoyl-L-proline (2a), had an I50 against angiotensin converting enzyme of 1.0 x 10-9 M and is the most potent inhibitor prepared thus far in this class of compounds. Testing of 2a orally at 30 mg/kg for inhibition of the angiotensin I induced blood pressure increase in conscious normotensive rats gave 100% inhibition that required 143 min before the angiotensin I blood pressure response returned to 70% of the pretreatment control response. In the conscious renal hypertensive rat, 2a given orally at a dose of 3 mg/kg caused a lowering of blood pressure that reached its maximum of 40 mmHg 8 h following drug administration.