10025-98-6Relevant articles and documents
Interaction of K2PdCl4 with aminoalkyldiphosphonic acids
Kozachkova,Dudko,Tsaryk,Trachevskii,Rozhenko,Pekhn'O
, p. 1494 - 1500 (2011)
Complexing of K2PdCl4 with 3-amino-1- hydroxypropylidene-1,1-diphosphonic acid (AHPDP) and 1-aminoethylidene-1,1- diphosphonic acid (AEDP) was studied by pH titration, spectrophotometry, and 31P NMR spectroscopy using metal to ligand mole ratios of 1: 1 and 1: 2. In equimolar complexes, AHPDP is coordinated to palladium(II) via two phosphonic oxygen atoms, whereas AEDP is coordinated via the amino nitrogen atom and a phosphonic oxygen atom. In the bisligand palladium(II) complex with AEDP, both ligand molecules are coordinated in a bidentate mode by the amino nitrogen atom and a phosphonic oxygen atom.
Five novel palladium(II) complexes of 8-hydroxyquinoline and amino acids with hydrophobic side chains: synthesis, characterization, cytotoxicity, DNA- and BSA-interaction studies
Mohammadi, Fatemeh,Mansouri-Torshizi, Hassan
, p. 3059 - 3073 (2020)
The side effects and resistance of metal-based anticancer drugs prompted us to synthesis a novel series of five Pd(II) complexes of the type [Pd(8-QO)(AA)]; where 8-QO = anion of 8-hydroxyquinoline and AA = anions of amino acids having nonpolar aliphatic side chain such as glycine (–H), alanine (–CH3), valine (–CH(CH3)2), leucine (–CH2–CH(CH3)2) and isoleucine (–CH(CH3)CH2–CH3). The complexes have been characterized with the help of FT-IR, UV–Vis, one and two-dimensional 1H-NMR, elemental analysis and conductivity measurements. On the basis of these characterization data, a four coordinated square planar geometry for all of these complexes have been proposed. The compounds were screened for their in vitro activities against human cancer cell line, MOLT-4 and their 50% inhibition concentration were ascertained by means of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)?assay. Since four out of the five newly synthesized compounds were found to be more active than the standard anticancer drug, cisplatin, their detailed interaction with calf thymus DNA (as a target) and bovine serum albumin (BSA) (as a carrier) were also carried out by utilizing absorption spectra, fluorescence spectra and ethidium bromide displacement studies. In these experiments, several binding and thermodynamic parameters were also calculated. These results suggested that hydrogen binding and van der Waals forces play a major role in the interaction between metal complexes with CT-DNA and BSA. Communicated by Ramaswamy H. Sarma.
Interaction of bis(alkylamine)dichloropalladium(II) complexes with CT-DNA and BSA; their synthesis, characterization, antitumor, and antibacterial evaluations
Mohammadlou, Farahnaz,Mansouri-Torshizi, Hassan,Abdi, Khatereh
, p. 1354 - 1372 (2021)
A series of five new and analogous palladium(II) alkylamine complexes of cisplatin derivatives such as cis-[Pd(alkyl-am)2Cl2], where alkyl-am is Ethyl-, Propyl-, Butyl-, Hexyl-, and Octyl-amine, have been prepared. They have been characterized by physicochemical methods such as FT-IR, 1H-NMR, UV-Vis, conductivity measurements and elemental analysis. These synthesized metal complexes were screened for their in-vitro antitumor activity against human MOLT-4 cells. Only [Pd(Octyl-am)2Cl2] showed moderate activity. They were also tested against some gram-negative (Escherichia coli) and gram-positive (Staphylococcus aureus) bacteria by measuring the values of IZ, MIC and MBC. All Pd(II) complexes displayed comparable activity with that of cefazoline as standard antibiotics. To clarify the mode of interaction between these compounds and CT-DNA and (BSA), their interaction behavior was checked using electronic absorption spectroscopy. Results indicated that all of the above mentioned Pd(II) complexes effectively interacted with CT-DNA and BSA at low concentration and the distance between the interacted Pd(II) complexes and BSA were in the range of 3.00–3.30 nm. Fluorescence emission studies revealed that the complexes quenched CT-DNA pretreated with methylene blue (MB) and the intrinsic fluorescence of BSA through static quenching procedure. Using the binding constant (K b) obtained from fluorescence studies, thermodynamic parameters (ΔG°, ΔH° and ΔS°) suggested that hydrogen bonding and van der Waals forces, as well as hydrophobic interaction, play the major role between metal complexes with CT-DNA and BSA. In all cases the binding forces were spontaneous owing to –ΔG°. Communicated by Ramaswamy H. Sarma.
Novel functionalized thiosemicarbazone ligands and their Pd(II) complexes: synthesis, characterization, antibacterial and cytotoxic activities
Hassan, Safaa S.,Gomha, Sobhi M.
, p. 331 - 344 (2019)
Palladium (II) complexes of coumarinyl thiosemicarbazone derivatives as 1-(1-(2-oxo-2H-chromen-3-yl) ethylidene) thiosemicarbazone (OCETh), 1-(1-(6-bromo-2-oxo-2H-chromen-3-yl) ethylidene) thiosemicarbazone (BOCETh) and 1-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene) thiosemicarbazone (NOCETh) were prepared. The complexes have the formula [Pd (L) Cl]. DMF, where DMF = dimethylformamide and L = OCETh, BOCETh or NOCETh. The studied ligands act as a tridentate ligand by using azomethine nitrogen, carbonyl oxygen and thiol sulfur as a monoanion center of donation. The characterization part was carried out using different physicochemical tools such as elemental analysis, IR, UV–visible, mass, magnetic measurement and molar conductance techniques. The theoretical conformational structure analyses were performed using density functional theory for ligands and complexes at B3LYP functional with 6–31 ++G(d,p) basis set for ligands and LANL2DZ basis set for complexes. The charge distribution within the ligands and its pd(II) complexes was calculated using Mulliken population analysis of (MPA) and natural population analysis (NPA). The prepared pd(II) complexes showed a satisfactory cytotoxic effect results against the human colon cancer cell line (HCT-116). Additionally, docking study was performed on colon cancer target cyclin-dependent kinase-2 to understand the cytotoxic modes of actions by the active compounds. The antibacterial activity was tested against some types of Gram-positive and negative bacteria. Molecular docking investigation proved that all synthesized compounds had interesting interactions with the active site amino acids of glucosamine-6-phosphate synthase. Density functional theory was used to theoretically analyze the conformational structure of the ligands and Pd (II) complexes.
Mononuclear perfluoroalkyl-heterocyclic complexes of PD(II): Synthesis, structural characterization and antimicrobial activity
Alduina, Rosa,Buscemi, Silvestre,Cancemi, Patrizia,Di Stefano, Vita,Girasolo, Maria Assunta,Orecchio, Santino,Pibiri, Ivana,Rubino, Simona
, (2020)
Two mononuclear Pd(II) complexes [PdCl2(pfptp)] (1) and [PdCl2(pfhtp)] (2), with ligands 2-(3-perfluoropropyl-1-methyl-1,2,4-triazole-5yl)-pyridine (pfptp) and 2-(3-perfluoroheptyl-1-methyl- 1,2,4-triazole-5yl)-pyridine (pfhtp), were synthesized and structurally characterized. The two complexes showed a bidentate coordination of the ligand occurring through N atom of pyridine ring and N4 atom of 1,2,4-triazole. Both complexes showed antimicrobial activity when tested against both Gram-negative and Gram-positive bacterial strains.
Dielectric constant and dielectric relaxation in aqueous solutions of K2[PdCl4] and K2[PtCl4]
Lyashchenko,Loginova,Lileev,Ivanova,Efimenko
, p. 633 - 639 (2009)
The MW-dielectric properties of aqueous solutions of K 2[PtCl4] (I) and K2[PdCl4] (II) were studied at 298 and 313 K in the frequency range (12-25 GHz) corresponding to the maximum dielectric constant dispersion
Pd(II) and Au(I) chloride complexes with tetrakis(butylthiomethyl)calix[4] arene: Synthesis and crystal structures
Kostin,Mashukov,Kurat'eva,Tkachev,Torgov,Drapailo
, p. 360 - 366 (2008)
Two novel complexes, (AuCl)4L3(I) and (PdCl 2)2L3(II) (L3 is calix[4]arene-thioether), were synthesized and their structures were determined. In complex I, one thioether group of molecule L3 is coordinated to every Au atom. In complex II, the bidentate coordination of L3 to the Pd atoms is observed; two thioether groups are in the trans-positions in the Pd square surrounding. Both complexes have the layered crystal lattices. In the Au complex, the layers are more stable due to the short contacts Au-Au (3.19-3.23 A).
Potentiometric and Speciation Studies on the Complex Formation Reactions of [Pd(2-methylaminomethyl)-pyridine)(H2O)2]2+ with Some Bio-active Ligands and Displacement Reaction of Coordinated Inosine
Abd El-Karim, Abeer T.,El-Sherif, Islam R.,Hosny, Wafaa M.,Alkhadhairi, Eyad K.,Aljahdali, Mutlaq S.,El-Sherif, Ahmed A.
, p. 1024 - 1047 (2017)
The stoichiometry and stability constants of the complexes formed between [Pd(MAMP)(H2O)2]2+ and various biologically relevant ligands containing different functional groups were investigated. The ligands used are amino acids, peptides and DNA constituents. The results show the formation of 1:1 complexes with amino acids and peptides and the corresponding deprotonated amide species. Structural effects of peptides on amide deprotonation were investigated. The purine and pyrimidine bases uracil, uridine, cytosine, inosine, inosine 5′-monophosphate (5′-IMP) and thymine form 1:1 and 1:2 complexes. The concentration distribution of the various complex species was calculated as a function of pH. The effect of chloride ion concentration on the formation constant of CBDCA with Pd(MAMP)2+ was also reported. The results show ring opening of CBDCA and monodentate complexation of the DNA constituent with the formation of [Pd(MAMP)(CBDCA-O)DNA], where (CBDCA-O) represents cyclobutane dicarboxylate coordinated by one carboxylate oxygen. The equilibrium constant of the displacement reaction of coordinated inosine, as a typical DNA constituent, by SMC and/or methionine was calculated. The results are expected to contribute to the chemistry of antitumor agents. The calculated parameters of the optimized complexes support the measured formation constants.
Electron-Density Distribution in Crystals of Dipotassium Tetrachloropalladate(II) and Dipotassium Hexachloropalladate(IV), K2 and K2 at 120 K
Takazawa, Hiroyuki,Ohba, Shigeru,Saito, Yoshihiko
, p. 580 - 585 (1988)
MoKα1, λ=0.70926 Angstroem, T=120 (2) K. (I): K2-, Mr=326.4, tetragonal, P4/mmm, a=7.0259 (3), c=4.0797 (2)Angstroem, V=201.39 (2)Angstroem3, Z=1, Dx=2.69 Mg m-3, μ=4.55 mm-1, F(000)=151.7, final R=0.021 for 893 unique reflections. (II):K2, Mr=397.3, cubic, Fm3m, a=9.6374 (4)Angstroem, V=895.12 (7)Angstroem3, Z=4, Dx=2.95 Mg m-3, μ=4.71 mm-1, F(000)=744.0, final R=0.011 for 393 unique reflections.The Pd-Cl bond lengths are 2.3066 (2) and 2.3094 (3)Angstroem for (I) and (II), respectively.The asphericity of the 4d electron distribution in the square-planar and octahedral Pd complexes could be decected clearly.Above and below the -2 plane of (I), excess densities of 2.3 (3)e Angstroem-3 are found 0.47 Angstroem from the Pd nucleus, suggesting enhancement of the dz2 orbital population.In (II), positive deformation densities corresponding to the t2g orbitals are observed in the directions at 0.5 Angstroem from the Pd nucleus and 1.4 (3) e Angstroem-3 in height.These charge asphericities could be reproduced by the multipole expansion method with reasonable d-orbital populations.
Multinuclear NMR spectroscopy and antiproliferative activity in vitro of platinum(II) and palladium(II) complexes with 6-mercaptopurine
?akomska, Iwona,Pazderski, Leszek,Sitkowski, Jerzy,Kozerski, Lech,Pe?czyńska, Marzena,Nasulewicz, Anna,Opolski, Adam,Sz?yk, Edward
, p. 241 - 247 (2004)
A series of Pd(II) and Pt(II) complexes with 6-mercaptopurine (6-Hmp) of formulae Pd(6-Hmp)2Cl2 (1), Pd(6-mp)2· 2H2O (2), Pt(6-mp)2·2H2O (3), Pt(6-mp)(dmso)Cl (4) was synthesized and studied by IR, far-IR, 1H, 13C, 15N NMR. (1) has an ionic character and consists of distinct [Pd(6-Hmp)2]2+ cations and uncoordinated Cl - anions, whereas (2,3) are neutral species with central atoms bis-chelated by the deprotonated 6-mp- ligands. NMR studies suggest that S and N(7) are the complexation sites, while far-IR spectra indicate the square-planar geometry of Pd(II) or Pt(II). In (4) the Pt(II) atom is coordinated by one chelating 6-mp- anion, S-bonded dmso molecule and a terminal chloride. The antiproliferative activity in vitro of (2-4) was tested against human leukaemia HL-60 cells, being exhibited for (2) at the level ca. six times lower than in case of cisplatin.
Synthesis, biological evaluation, substitution behaviour and DFT study of Pd(II) complexes incorporating benzimidazole derivative
Mitra, Ishani,Mukherjee, Subhajit,Reddy, Venkata P.,Misini, Bashkim,Das, Payel,Dasgupta, Subrata,Linert, Wolfgang,Moi, Sankar C.
, p. 2574 - 2589 (2018)
To achieve potent yet specific antitum agents, a series of palladium(ii) complexes (C1-C6) employing the carrier ligand 2-aminomethylbenzimidazole with DNA intercalating property and diverse ancillary groups (chloride, aqua, thiol) were synthesized and characterized. The kinetic parameters of the reactivity of the diaqua complex C2 towards selected sulphur-containing biomolecules were evaluated under pseudo-first order reaction conditions. Theoretical calculations such as NBO and TD-DFT were found to corroborate with spectroscopic results. Intercalative/groove binding nature of calf-thymus DNA (CT-DNA) interaction for the complexes was confirmed by various physico-chemical techniques and molecular docking. A strong association of the complexes with bovine serum albumin (BSA) via a static mechanism was demonstrated by absorption and emission measurements. The anti-proliferative effects of the complexes were tested against human breast tumor MDA-MB-231, human lung carcinoma A549 and human hepatocellular liver carcinoma HepG2. The complexes exhibited inhibitory effects greater than that exhibited by recognized drug cisplatin on the MDA-MB-231 cell line. Notably, the growth inhibition as well as oxidative stress elicited by the complexes in non-malignant cell lines L6 myotubes (rat myoblasts) and HEK-293 (human embryonic kidney cells) was much less than by cisplatin.
Polar functional groups anchored to a 2D MOF template for the stabilization of Pd(0) nps for the catalytic C-C coupling reaction
Adalikwu, Stephen Adie,Mothika, Venkata Suresh,Hazra, Arpan,Maji, Tapas Kumar
, p. 7117 - 7121 (2019)
A 2D porous MOF, {[Cu(1,2,3-btc)(bpe)(H2O)]·H2O}n (1), has been synthesized using a mixed linker system. The structural determination showed non-coordinated carboxylate groups decorating the pore surface. The desolvated MOF (1a) with pendant carboxylate groups was used as a template for the stabilization of Pd nps (2-3 nm) and the resulting composite Pd(0)@1a showed efficient catalytic activity for the Suzuki-Miyaura C-C coupling reaction.
Theoretical hydrolysis mechanism of anticancer Pt(II) and Pd(II) dichloro complexes with N, N bidentate chelator in aqueous medium and their molecular docking
Bhaduri, Rituparna,Ch. Moi, Sankar,Kumar Tarai, Swarup,Mandal, Saikat,Misra, Koyel,Pan, Angana,Venkata Pera Reddy, B.
, (2021/11/11)
Theoretical hydrolysis mechanism of Pt(II) and Pd(II) dichloro complexes with bidentate N, N chelated cis-[Pt(AEP)Cl2] and cis-[Pd(AEP)Cl2] (where AEP = 1-(2-Aminoethyl)-pyrrolidine) were studied with the help of DFT. Penta-coordinat
