100277-55-2

Basic information

• Product Name: ethyl (2S)-6-(1-benzyloxycarbonyl-4-piperidyl)-2-hydroxyhexanoate
• Synonyms: ethyl (2S)-6-(1-benzyloxycarbonyl-4-piperidyl)-2-hydroxyhexanoate
• CAS NO: 100277-55-2
• Molecular Weight: 377.481
• Mol File: 100277-55-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl (2S)-6-(1-benzyloxycarbonyl-4-piperidyl)-2-hydroxyhexanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (2S)-6-(1-benzyloxycarbonyl-4-piperidyl)-2-hydroxyhexanoate(100277-55-2)
• EPA Substance Registry System: ethyl (2S)-6-(1-benzyloxycarbonyl-4-piperidyl)-2-hydroxyhexanoate(100277-55-2)

Safety Data

• Hazardous Substances Data: 100277-55-2(Hazardous Substances Data)

Upstream product

• 100277-56-3 4-((S)-5-Ethoxycarbonyl-5-methanesulfonyloxy-pentyl)-piperidine-1-carboxylic acid benzyl ester 
• 99198-86-4 ethyl (R)-6-(1-benzyloxycarbonyl-4-piperidyl)-2-hydroxyhexanoate 
• 100277-53-0 4-((S)-5-Carboxy-5-hydroxy-pentyl)-piperidine-1-carboxylic acid benzyl ester 
• 100277-57-4 4-((R)-5-Ethoxycarbonyl-5-propionyloxy-pentyl)-piperidine-1-carboxylic acid benzyl ester 
• 99198-61-5 ethyl 6-(1-benzyloxycarbonyl-4-piperidyl)-2-oxohexanoate 
• 64-17-5 ethanol 
• 100277-58-5 4-((R)-5-Carboxy-5-hydroxy-pentyl)-piperidine-1-carboxylic acid benzyl ester 

Downstream Products

• 100277-57-4 4-((R)-5-Ethoxycarbonyl-5-propionyloxy-pentyl)-piperidine-1-carboxylic acid benzyl ester 
• 100277-58-5 4-((R)-5-Carboxy-5-hydroxy-pentyl)-piperidine-1-carboxylic acid benzyl ester 
• 100277-52-9 ethyl (2R)-6-(1-benzyloxycarbonyl-4-piperidyl)-2-hydroxyhexanoate 
• 100277-56-3 4-((S)-5-Ethoxycarbonyl-5-methanesulfonyloxy-pentyl)-piperidine-1-carboxylic acid benzyl ester 
• 110452-99-8 4-((R)-5-Benzoyloxy-5-ethoxycarbonyl-pentyl)-piperidine-1-carboxylic acid benzyl ester 
• 110452-98-7 ethyl (S)-2-benzoyloxy-6-(1-benzyloxycarbonyl-4-piperidyl)hexanoate 
• 100277-53-0 4-((S)-5-Carboxy-5-hydroxy-pentyl)-piperidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Synthesis and angiotensin converting enzyme-inhibitory activity of N- [(1S)-1-carboxy-5-(4-piperidyl)pentyl]-L-alanine derivatives

As part of a search for potent and long-lasting angiotensin converting enzyme (ACE) inhibitors, various types of N-[(1S)-1-carboxy-5-(4- piperidyl)pentyl]-L-alanine derivatives (7a, 8-11) were prepared. The key synthetic intermediate, N-[(1S)-5-(1-benzyloxycarbonyl-4-piperidyl)-1- ethoxycarbonylpentyl]-L-alanine (17a), was synthesized by asymmetric reduction of the α-oxoester (13) with Lactobacillus paracasei subsp. paracasei followed by a substitution reaction with tert-butyl L-alanine (15) and subsequent treatment with hydrogen chloride. Compounds 7a and 8-11 showed potent and long-lasting ACE-inhibitory activity in rats.