10029-91-1

Basic information

• Product Name: Aziridine, 2-(4-methoxyphenyl)-
• CAS NO: 10029-91-1
• Molecular Formula: C9H11NO
• Molecular Weight: 149.192
• Mol File: 10029-91-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Aziridine, 2-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Aziridine, 2-(4-methoxyphenyl)-(10029-91-1)
• EPA Substance Registry System: Aziridine, 2-(4-methoxyphenyl)-(10029-91-1)

Safety Data

• Hazardous Substances Data: 10029-91-1(Hazardous Substances Data)

Upstream product

• 637-69-4 4-Methoxystyrene 
• 105028-81-7 [2-Iodo-2-(4-methoxy-phenyl)-ethyl]-carbamic acid methyl ester 
• 915288-76-5 1-(1-azido-2-iodoethyl)-4-methoxybenzene 
• 2475-92-5 4-methoxyacetophenone oxime 
• 34910-42-4 1-(1-azidovinyl)-4-methoxybenzene 

Downstream Products

• 889674-48-0 4,5-dihydro-7-methoxy-3-(p-methoxyphenyl)-benzo[g]indole 
• 1040271-37-1 3-[2-(4-methoxy-phenyl)-aziridin-1-yl]-cyclopent-2-enone 
• 113009-72-6 ethyl bis(2-(p-methoxyphenyl)-1-aziridinyl)phosphinate 

Relevant articles and documents

Structure and Reactivity of a Manganese(VI) Nitrido Complex Bearing a Tetraamido Macrocyclic Ligand

Manganese complexes in +6 oxidation state are rare. Although a number of Mn(VI) nitrido complexes have been generated in solution via one-electron oxidation of the corresponding Mn(V) nitrido species, they are too unstable to isolate. Herein we report the isolation and the X-ray structure of a Mn(VI) nitrido complex, [MnVI(N)(TAML)]- (2), which was obtained by one-electron oxidation of [MnV(N)(TAML)]2- (1). 2 undergoes N atom transfer to PPh3 and styrenes to give Ph3P═NH and aziridines, respectively. A Hammett study for various p-substituted styrenes gives a V-shaped plot; this is rationalized by the ability of 2 to function as either an electrophile or a nucleophile. 2 also undergoes hydride transfer reactions with NADH analogues, such as 10-methyl-9,10-dihydroacridine (AcrH2) and 1-benzyl-1,4-dihydronicotinamide (BNAH). A kinetic isotope effect of 7.3 was obtained when kinetic studies were carried out with AcrH2 and AcrD2. The reaction of 2 with NADH analogues results in the formation of [MnV(N)(TAML-H+)]- (3), which was characterized by ESI/MS, IR spectroscopy, and X-ray crystallography. These results indicate that this reaction occurs via an initial "separated CPET"(separated concerted proton-electron transfer) mechanism; that is, there is a concerted transfer of 1 e- + 1 H+ from AcrH2 (or BNAH) to 2, in which the electron is transferred to the MnVI center, while the proton is transferred to a carbonyl oxygen of TAML rather than to the nitrido ligand.

CEPHALOTAXUS ESTERS, METHODS OF SYNTHESIS, AND USES THEREOF

The present invention provides novel cephalotaxus esters, syntheses thereof, and intermediates thereto. The invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of using said compounds or compositions in the treatment of proliferative diseases (e.g., benign neoplasm, cancer, inflammatory disease, autoimmune disease, diabetic retinopathy) and infectious disease. The invention further provides methods of using said compounds or compositions in the treatment of multidrug resistant cancer.

Conformationally restricted aza-BODIPY: Highly fluorescent, stable near-infrared absorbing dyes

Novel NIR fluorescent, conformational restricted aza-dipyrromethene boron difluoride (aza-BODIPY) dyes were prepared by an efficient process. Such conformational restricted aza-BODIPY dyes possess intense absorption, strong fluorescence, high chemical and