100296-95-5

Basic information

• Product Name: 3-((S)-1-Hydroxy-ethyl)-1-(4-methoxy-phenyl)-4-((E)-styryl)-azetidin-2-one
• CAS NO: 100296-95-5
• Molecular Weight: 323.392
• Mol File: 100296-95-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-((S)-1-Hydroxy-ethyl)-1-(4-methoxy-phenyl)-4-((E)-styryl)-azetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((S)-1-Hydroxy-ethyl)-1-(4-methoxy-phenyl)-4-((E)-styryl)-azetidin-2-one(100296-95-5)
• EPA Substance Registry System: 3-((S)-1-Hydroxy-ethyl)-1-(4-methoxy-phenyl)-4-((E)-styryl)-azetidin-2-one(100296-95-5)

Safety Data

• Hazardous Substances Data: 100296-95-5(Hazardous Substances Data)

Upstream product

• 15286-52-9 N-(4-Methoxyphenyl)-3-phenylpropenaldimine 
• 56816-01-4 ethyl (S)-3-hydroxybutyrate 
• 80542-40-1 N-cinnamylidene-p-anisidine 
• 5405-41-4 ethyl 3-hydroxybutyrate 
• 88315-63-3 (E)-4-methoxy-N-((E)-3-phenylallylidene)aniline 

Downstream Products

• 115133-15-8 (1S,2S,4R,6S)-4-methoxy-2-methyl-7-(oxo(phenylmethoxy)acetyl)-3-oxa-7-azabicyclo(4.2.0)octan-8-one 
• 123493-06-1 (2S,3R,4S,6R)-methyl-4-(benzoylamino)-tetrahydro-6-methoxy-2-methyl-2H-pyran-3-carboxylate 
• 123493-07-2 (2S,3R,4S,6R)-4-(benzoylamino)-tetrahydro-6-methoxy-2-methyl-2-pyran-3-carboxylic acid 
• 123493-09-4 (2S,3R,4S,6R)-3-acetyl-4-benzoylamino-6-methoxy-2-(methyl)tetrahydro-2H-pyran 
• 123493-08-3 (2S,3S,4S,6R)-3-acetyl-4-benzoylamino-6-methoxy-2-(methyl)tetrahydro-2H-pyran 
• 115133-12-5 (1S,2S,4R,6S)-7-benzoyl-4-methoxy-2-methyl-3-oxa-7-azabicyclo(4.2.0)octan-8-one 
• 115133-11-4 (1S,2S,4R,6S)-4-methoxy-7-(4-methoxyphenyl)-2-methyl-3-oxa-7-azabicyclo(4.2.0)octan-8-one 
• 115133-10-3 (3S,4S(E))-3-(1(S)-hydroxyethyl)-4-(2-methoxyethenyl)-1-(4-methoxyphenyl)-2-azetidinone 
• 115133-09-0 (1S,2S,4R,5R)-4-hydroxy-6-(4-methoxyphenyl)-2-methyl-3-oxa-6-azabicyclo(3.2.0)heptan-7-one 
• 115184-79-7 (1R,2S,4R,5S)-4-hydroxy-6-(4-methoxyphenyl)-2-methyl-3-oxa-6-azabicyclo(3.2.0.)heptan-7-one 
• 54656-60-9 methyl 3-benzamido-2,3,6-trideoxy-α-L-arabino-hexopyranoside 
• 115133-10-3 (3S,4S)-3-((S)-1-Hydroxy-ethyl)-1-(4-methoxy-phenyl)-4-((E)-2-methoxy-vinyl)-azetidin-2-one 
• 102129-92-0 (3R,4S(E))-3-(1(S)-(((1,1-dimethylethyl)dimethylsilyl)oxy)ethyl)-1-(4-methoxyphenyl)-4-(2-phenylethenyl)-2-azetidinone 
• 101977-84-8 (1'S,3S,4R)-3-(1'-<(tert-butyldimethylsilyl)oxy>ethyl)-1-(4'-methoxyphenyl)-4-(2'-phenylethenyl)-2-azetidinone 

Relevant articles and documents

Preparation of Aminosaccharides Using Ester-Imine Condensations: Syntheses of Methyl N-Benzoylacosaminide and Methyl N-(Oxo(phenylmethoxy)acetyl)daunosaminide from (S)-Ethyl 3-Hydroxybutyrate

The dianion of (S)-ethyl β-hydroxybutyrate (1) was treated with N-trimethylsilyl imine 2 to afford β-lactam 4.The same dianion reacted with N-aryl imine 10 to give β-lactams 11, 12, and 13.A three-step sequence was used to convert 4 into the β-lactam-pyra

3-(1'-hydroxyethyl)-2-azetidinones from 3-hydroxybutyrates and N-arylaldimines

Dianion imine addition, cyclisation reaction between ethyl-3-hydroxybutyrate and the aldimines generates β-lactams with the hydroxyethyl side chain of thienamycin and related β-lactam antibiotics in place. The effects of the N-arylaldimine and the reactio