100298-29-1Relevant articles and documents
TOTAL SYNTHESIS OF NATURAL ESTRONE AND ESTRADIOL METHYL ETHERS IN EXTREMELY HIGH ENANTIOMERIC PURITY VIA AN ASYMMETRIC MICHAEL ADDITION TO AN UNSTURATED SULFOXIDE
Posner, Gary H.,Switzer, Christopher
, p. 1239 - 1244 (2007/10/02)
Methoxytetralone enolate ion 1b underwent an asymmetric Michael addition to enantiomerically pure cyclopentenone sulfoxide (S)-(+)-2 with a diastereoslectivity of 91-94percent.A series of eight additional steps led to (+)-estrone methyl ether (11) in over