1003-68-5

Basic information

• Product Name: 2-Hydroxy-5-methylpyridine
• Synonyms: 6-HYDROXY-3-PICOLINE;5-METHYL-2(1H)PYPRIDINONE;5-METHYL-2(1H)-PYRIDINONE;5-METHYL-2(1H)PYRIDONE;5-METHYL-2-PYRIDINOL;5-METHYL-PYRIDIN-2-OL;5-METHYLPYRIDINE-2-ONE;AKOS BBS-00002970
• CAS NO: 1003-68-5
• Molecular Formula: C₆H₇NO
• Molecular Weight: 109.13
• EINECS: 213-713-9
• Product Categories: Pyridine;Pyridines;Chemical Amines;Amines;Aromatics;Heterocycles;C6;Heterocyclic Building Blocks;Heterocycle-Pyridine series;alcohol;Imidazoles
• Mol File: 1003-68-5.mol
• Article Data: 33

Chemical Properties

• Melting Point: 183-187 °C(lit.)
• Boiling Point: 304.2 °C at 760 mmHg
• Flash Point: 170.6 °C
• Appearance: white solid
• Density: 1.053 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
• PKA: 12.43±0.10(Predicted)
• BRN: 107074
• CAS DataBase Reference: 2-Hydroxy-5-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-5-methylpyridine(1003-68-5)
• EPA Substance Registry System: 2-Hydroxy-5-methylpyridine(1003-68-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41-36/37/39
• Safety Statements: 26-36-37
• WGK Germany: 3
• Hazardous Substances Data: 1003-68-5(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

2-Hydroxy-5-methylpyridine (cas# 1003-68-5) is a useful compound for organic synthesis. In particular it has been used for the diastereoselective preparation of cyclobutane-fused pyridinyl sulfonyl fluorides.

InChI:InChI=1/C6H7NO/c1-5-2-3-7-6(8)4-5/h2-4H,1H3,(H,7,8)

Upstream product

• 1003-56-1 3-methylpyridin-2-ol 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 15790-87-1 Methyl (E)-2-pentenoate 
• 2369-19-9 2-fluoro-5-methylpyridine 
• 1003-68-5 5-methyl-pyridin-2-ol 
• 13472-85-0 2-methoxy-5-bromopyridine 
• 3510-66-5 2-Bromo-5-methylpyridine 
• 108-99-6 3-Methylpyridine 
• 72323-49-0 8-methyl-2,4-diaza-bicyclo[4.2.0]oct-7-ene-3,5-dione 
• 89478-78-4 5-Methyl-1-(6-phenyl-4-p-tolyl-pyridine-2-carbonyl)-1H-pyridin-2-one 
• 89478-71-7 1-(4,6-Diphenyl-pyridine-2-carbonyl)-5-methyl-1H-pyridin-2-one 
• 83766-91-0 5-methyl-2-ethoxypyridine 
• 1007-56-3 5-methylpyridin-2-yl acetate 
• 91936-25-3 5-methyl-3,4-dihydropyridine-2(1H)-one 

Downstream Products

• 6456-93-5 1,5-dimethylpyridin-2(1H)-one 
• 18368-64-4 2-chloro-5-methylpyridine 
• 3510-66-5 2-Bromo-5-methylpyridine 
• 51933-81-4 5-methyl-2-phenoxypyridine 
• 1762-34-1 5,5'-dimethyl-2,2'-bipyridine 
• 1802-30-8 2,2'-bipyridine-5,5'-dicarboxylic acid 
• 1762-45-4 (2,2′-bipyridine)-5,5′-dicarboxylic acid dimethyl ester 
• 53427-77-3 5-methyl-N-(4-methoxyphenyl)-(1H )pyridin-2-one 
• 53179-13-8 Pirfenidone 
• 53427-79-5 5-Methyl-1-(3'-trifluoromethylphenyl)-2-(1H) pyridone 
• 27012-22-2 5-methyl-2-phenylpyridine 
• 92444-98-9 1-benzyl-5-methylpyridin-2(1H)-one 
• 25363-55-7 2-(4-methoxylphenyl)-5-methylpyridine 
• 851518-71-3 1-(4-hydroxyphenyl)-5-methylpyridine-2(1H)-one 

Relevant articles and documents

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Manganese-Promoted Regioselective Direct C3-Phosphinoylation of 2-Pyridones

A highly efficient and regioselective manganese-induced radical oxidative direct C?P bond formation between 2-pyridones and secondary phosphine oxides was developed. The C3-selective phosphinoylation was conveniently achieved through a combination of substoichiometric manganese and persulfate oxidant under mild conditions. Various 3-phosphinoylated pyridone products can be obtained in moderate to high yields. Preliminary mechanistic studies suggest that the reaction is likely to involve a radical pathway induced by catalytically active Mn3+ species.

Preparation method of high-purity pirfenidone

The invention relates to the technical field of drug synthesis, and discloses a preparation method of high-purity pirfenidone. The preparation method at least comprises the following steps: (1) uniformly mixing 2-amino-5-methylpyridine, a diazotization reagent and water, cooling to a temperature of -4 DEG C to 3 DEG C, adding an acid solution, and carrying out a thermal insulation reaction; heating for hydrolysis after the reaction is completed, cooling, then adjusting the pH value to 6.5-7.5 by using a sodium hydroxide solution with the mass fraction of 30%, extracting an organic phase by using a first solvent, drying, and concentrating under reduced pressure to obtain a 2-hydroxy 5-methylpyridine crude product; (2) adding a second solvent into the 2-hydroxy 5-methylpyridine crude productfor recrystallization to obtain a 2-hydroxy 5-methylpyridine pure product; (3) uniformly mixing the 2-hydroxy 5-methylpyridine pure product, iodobenzene, a catalyst and anhydrous potassium carbonate,heating and reacting, carrying out suction filtration, and carrying out vacuum concentration to obtain a pirfenidone crude product; and (4) adding a third solvent into the pirfenidone crude product,heating to dissolve, cooling to -5 to 5 DEG C, crystallizing for 1 to 1.5 hours, carrying out suction filtration, and drying to obtain a pirfenidone pure product.

5-alkyl-N-substituted aryl pyridone derivative, preparation method thereof and application of derivative

The invention provides a compound as shown in a formula I, or pharmacologically acceptable salt of the compound, or a prodrug of the compound, or a hydrate or solvate of the compound or a crystal form of the compound. The invention further provides a preparation method and an application of the compound. The structurally novel 5-methyl-2(1H) pyridone derivative as shown in the formula I has an obvious inhibiting effect on fibroblast proliferation and fibroblast secretory fiber binding protein (Fn), and the inhibiting effect is more significant than that of a positive drug pirfenidone (PF). The compound has an excellent application prospect in preparation of drugs for treating or preventing diseases such as fibrosis diseases and tumors.