1003043-73-9 Usage
General Description
The chemical (2-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyridin-4-yl)boronic acid is a boronic acid derivative that contains a piperazine and pyridine groups. It is commonly used in organic synthesis and medicinal chemistry as a building block for creating various pharmaceutical compounds and agrochemicals. (2-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyridin-4-yl)boronic acid has the potential to form stable bonds with diols and amines, making it useful in the development of new drug candidates and materials. Additionally, it has been studied for its potential as a therapeutic agent for the treatment of various diseases and conditions. Overall, (2-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyridin-4-yl)boronic acid is a versatile molecule with important applications in drug discovery and chemical research.
Check Digit Verification of cas no
The CAS Registry Mumber 1003043-73-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,3,0,4 and 3 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1003043-73:
(9*1)+(8*0)+(7*0)+(6*3)+(5*0)+(4*4)+(3*3)+(2*7)+(1*3)=69
69 % 10 = 9
So 1003043-73-9 is a valid CAS Registry Number.
1003043-73-9Relevant articles and documents
PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS
-
Page/Page column 60, (2012/04/17)
The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by inhibition of Syk kinase and/or Janus kinases.
Highly potent aminopyridines as Syk kinase inhibitors
Castillo, Marcos,Forns, Pilar,Erra, Montse,Mir, Marta,Lopez, Manel,Maldonado, Monica,Orellana, Adelina,Carreno, Cristina,Ramis, Isabel,Miralpeix, Montserrat,Vidal, Bernat
, p. 5419 - 5423 (2012/09/22)
A novel class of potent Syk inhibitors has been developed from rational design. Highly potent aminopyridine derivatives bearing a 4-trifluoromethyl-2- pyridyl motif and represented by compound 13b IC50: 0.6 nM were identified. Substitution by a 2-pyrazinyl motif and SAR expansion in position 4 of the central core provided diverse potent non-cytotoxic Syk inhibitors showing nanomolar activity inhibiting human mast cell line LAD2 degranulation.
