100331-91-7

Basic information

• Product Name: 5-(2,2-Dihydroxyacetyl)-8-(benzyloxy)-carbostyril
• Synonyms: 5-(2,2-Dihydroxyacetyl)-8-(benzyloxy)-carbostyril
• CAS NO: 100331-91-7
• Molecular Weight: 325.321
• Mol File: 100331-91-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(2,2-Dihydroxyacetyl)-8-(benzyloxy)-carbostyril(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,2-Dihydroxyacetyl)-8-(benzyloxy)-carbostyril(100331-91-7)
• EPA Substance Registry System: 5-(2,2-Dihydroxyacetyl)-8-(benzyloxy)-carbostyril(100331-91-7)

Safety Data

• Hazardous Substances Data: 100331-91-7(Hazardous Substances Data)

Upstream product

• 93609-84-8 5-acetyl-8-benzyloxy-1H-quinolin-2-one 

Downstream Products

• 1021156-76-2 8-(benzyloxy)-5-[(1R,S)-2-({2-[4-(3,3-difluoro-3-phenylpropoxy)-phenyl]ethyl}amino)-1-hydroxyethyl]quinolin-2(1H)-one 
• 1021156-86-4 C₃₅H₃₄F₂N₂O₅ 
• 1021156-47-7 8-(benzyloxy)-5-[(1R,S)-2-({2-[4-(2,2-difluoro-2-phenylethoxy)phenyl]ethyl}amino)-1-hydroxyethyl]quinolin-2(1H)-one 
• 1185466-94-7 8-(benzyloxy)-5-((1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-{[2-(4-nitrophenyl)ethyl]amino}ethyl)quinolin-2(1H)-one 
• 1185465-21-7 N-benzyl-N'-{3-[2-({(2R,S)-2-[8-(benzyloxy)-2-oxo-1,2-dihydro-quinolin-5-yl]-2-hydroxyethyl}amino)ethyl]phenyl}urea 
• 1185465-28-4 N-{3-[2-({(2R,S)-2-[8-(benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl]-2-hydroxyethyl}amino)ethyl]phenyl}-N'-(4-fluorobenzyl)urea 
• 1185465-37-5 N-{3-[2-({(2R,S)-2-[8-(benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl]-2-hydroxyethyl}amino)ethyl]phenyl}-N'-(3-phenylpropyl)urea 

Relevant articles and documents

Design, synthesis and biological evaluation of 5-(2-amino-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one derivatives as potent β2-adrenoceptor agonists

A series of novel β2-adrenoceptor agonists with a 5-(2-amino-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one moiety was designed, synthesized and evaluated for biological activity in human embryonic kidney 293 cells and isolated guinea pig trachea. Compounds 9g and (R)-18c exhibited the most excellent β2-adrenoceptor agonistic effects and high β2/β1-selectivity with EC50 values of 36 pM for 9g and 21 pM for (R)-18c. They produced potent airway smooth muscle relaxant effects with fast onset of action and long duration of action in an in vitro guinea pig trachea model of bronchodilation. These results support further development of the two compounds into drug candidates.