1003316-11-7

Basic information

• Product Name: N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester
• Synonyms: N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester;N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic acid 1,1-dimethylethyl ester
• CAS NO: 1003316-11-7
• Molecular Formula: C₃₃H₂₉N₃O₅
• Molecular Weight: 547.60046
• Mol File: 1003316-11-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Dichloromethane, Methanol
• CAS DataBase Reference: N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester(1003316-11-7)
• EPA Substance Registry System: N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester(1003316-11-7)

Safety Data

• Hazardous Substances Data: 1003316-11-7(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 1003316-11-7 differently. You can refer to the following data:
1. N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester is a reactant used in the preparation of carboxybenzylamino biaryls as histon e deacetylase inhibitors.
2. N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1''-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester is a reactant used in the preparation of carboxybenzylamino biaryls as histone deacetylase inhibitors.

Upstream product

• 335254-77-8 tert-butyl (3-nitro-[1, 1'-biphenyl]-4-yl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 327046-79-7 tert-butyl (4-bromo-2-nitrophenyl)carbamate 
• 875-51-4 4-Bromo-2-nitroaniline 
• 136918-14-4 phthalimide 
• 1003316-10-6 tert-butyl 3-(4-(chloromethyl)benzamido)biphenyl-4-ylcarbamate 
• 1074-82-4 potassium phtalimide 
• 335255-33-9 tert-butyl (3-amino-4-biphenylyl)carbamate 

Downstream Products

• 1003316-12-8 tert-butyl (3-(4-(aminomethyl)benzamido)-[1,1'-biphenyl]-4-yl)carbamate 
• 1013330-69-2 1,1-dimethylethyl [3-({[4-({[(methyloxy)carbonyl]amino}methyl)phenyl]carbonyl}amino)biphenyl-4-yl]carbamate 

Relevant articles and documents

Design and Synthesis of Novel N-(2-aminophenyl)benzamide Derivatives as Histone Deacetylase Inhibitors and Their Antitumor Activity Study

Histone deacetylases (HDACs) are promising therapeutic targets for cancer therapy because inhibition of HDACs triggers growth arrest or apoptosis of tumor cells. In the present study, a new series of fluorinated N-(2-aminophenyl)benzamide derivatives were synthesized to investigate potential inhibition of HDACs and associated anticancer activity. Among the synthesized derivatives, compound 24a showed potent inhibitory activity of HDACs and higher antitumor efficacy in human cancer cell lines (HCT-116, MCF-7, and A549) compared with SAHA. Moreover, animal studies demonstrated that compound 24a showed potent in vivo antitumor efficacy in an HCT-116 colon cancer xenograft mouse model.

4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS

The present invention relates to a novel class of 4-carboxybenzylamino derivatives. The 4-carboxybenzylamino compounds can be used to treat cancer. The 4-carboxybenzylamino compounds can also inhibit histone deacetylase and are suitable for use in selecti

PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS

The present invention relates to a novel class of phosphorus derivatives. The phosphorus compounds can be used to treat cancer. The phosphorus compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differe