100332-12-5 Usage
Uses
Used in Pharmaceutical Industry:
3-Piperidinemethanol, 4-(4-fluorophenyl)-1-methyl-, (3R,4R)was used as a weight loss medication for the treatment of obesity. It was utilized as a selective serotonin 2C receptor agonist for its appetite-suppressing and satiety-inducing effects, which contributed to reduced food intake and weight loss.
However, due to the withdrawal of Lorcaserin from the market in 2020, its applications in the pharmaceutical industry have been discontinued. The safety concerns that led to its withdrawal highlight the importance of ongoing monitoring and evaluation of pharmaceutical products to ensure patient safety and efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 100332-12-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,3,3 and 2 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 100332-12:
(8*1)+(7*0)+(6*0)+(5*3)+(4*3)+(3*2)+(2*1)+(1*2)=45
45 % 10 = 5
So 100332-12-5 is a valid CAS Registry Number.
100332-12-5Relevant articles and documents
Process for the preparation of optically enriched 4-aryl-3-hydromethyl substituted piperidines to be used as intermediates in the synthesis of paroxetine
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, (2008/06/13)
The subject invention pertains to optically-enriched compounds of formula (1), wherein Ar is a C6-20 aryl group; and R1 and R2 are independently H, alkyl or aryl. The subject invention also pertains to method of preparing these compounds. The subject compounds can be prepared by reduction of the corresponding 1,4-dihydropyridine-3-aldehyde, e.g., using hydrogen an a catalyst. The aldehyde can be prepared by hydrolytic cleavage of an aminal obtainable by the reaction of 3-pyridinecarboxaldehyde and a chiral C-2 symmetric diamine, an then stereoselective introduction of the Ar and COOCHR1 R2 groups. STR1
