10035-29-7

Basic information

• Product Name: (7cis,11cis)-17-cycloretinoic acid
• CAS NO: 10035-29-7
• Molecular Formula: C₂₀H₂₆O₂
• Molecular Weight: 298.4192
• Mol File: 10035-29-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 473.5°C at 760 mmHg
• Flash Point: 200.5°C
• Density: 1.03g/cm³
• Vapor Pressure: 3.91E-09mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: (7cis,11cis)-17-cycloretinoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (7cis,11cis)-17-cycloretinoic acid(10035-29-7)
• EPA Substance Registry System: (7cis,11cis)-17-cycloretinoic acid(10035-29-7)

Safety Data

• Hazardous Substances Data: 10035-29-7(Hazardous Substances Data)

Usage

General Description

(7cis,11cis)-17-cycloretinoic acid is a synthetic derivative of retinoic acid, which is a biologically active form of vitamin A. This chemical compound is a cyclopropene-containing retinoid that has been studied for its potential use in cancer treatment. It is known to have strong binding affinity to the retinoic acid receptors, which are involved in regulating gene expression and cell differentiation. Studies have shown that (7cis,11cis)-17-cycloretinoic acid has anti-proliferative and pro-apoptotic effects on cancer cells, making it a potential candidate for targeted cancer therapy. It is still under investigation for its safety and efficacy in treating various types of cancer.

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Relevant articles and documents

Regioselective synthesis of (E)-5-(tributylstannylmethylidene)-5H-furan-2- ones and (E)-3-(tributylstannylmethylidene)-3H-isobenzofuran-1-ones: Easy access to γ-alkylidenebutenolide and phthalide skeletons

Regio- and stereoselective synthesis of γ-alkylidene-butenolides and γ-alkylidenephthalides has been achieved through the palladium-catalysed tandem cross-coupling/cyclisation reactions of tributylstannyl-3-iodopropenoate or the 2-iodo benzoate derivatives with tributyltinacetylene. Iododestannylation occurred with inversion of the configuration of the exocyclic double bond in the case of butenolides, but with retention of configuration for the phthalide. The selectivity observed in the Stille reaction was found to be dependent on the nature of the vinyl or the aryl halide. Georg Thieme Verlag Stuttgart.