1003578-77-5

Basic information

• Product Name: 1-phenyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid (2-aminoethyl)amide hydrochloride
• Synonyms: 1-phenyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid (2-aminoethyl)amide hydrochloride
• CAS NO: 1003578-77-5
• Molecular Weight: 334.729
• Mol File: 1003578-77-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-phenyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid (2-aminoethyl)amide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid (2-aminoethyl)amide hydrochloride(1003578-77-5)
• EPA Substance Registry System: 1-phenyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid (2-aminoethyl)amide hydrochloride(1003578-77-5)

Safety Data

• Hazardous Substances Data: 1003578-77-5(Hazardous Substances Data)

Upstream product

• 1227166-15-5 tert-butyl [2-({[1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]carbonyl}amino)ethyl]carbamate 
• 1003578-67-3 N-(2-aminoethyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide 

Downstream Products

• 1003577-58-9 6-chloro-N-[2-({[1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]carbonyl}amino)ethyl]pyridine-3-carboxamide 

Relevant articles and documents

Discovery and optimization of adamantane carboxylic acid derivatives as potent diacylglycerol acyltransferase 1 inhibitors for the potential treatment of obesity and diabetes

Abstract We have developed a series of adamantane carboxylic acid derivatives exhibiting potent diacylglycerol acyltransferase 1 (DGAT1) inhibitory activities. Optimization of the series led to the discovery of E-adamantane carboxylic acid compound 43c, which showed excellent in vitro activity with an IC50 value of 5 nM against human and mouse DGAT1, also good druggability as well as microsomal stability and safety profiles such as hERG, CYP and cytotoxicity. Compound 43c significantly reduced plasma triglyceride levels in vivo (in rodents and zebrafish) and also showed bodyweight gain reduction and glucose area under curve (AUC) lowering efficacy in diet-induced obesity (DIO) mice.

AMIDE COMPOUNDS

The present invention provides compounds represented by the formula (Ia) the formula (Ib) the formula (Ic) and the formula (Id) wherein each symbol is as defined in the specification. According to the present invention, these compounds have a DGAT inhibit