100367-37-1

Basic information

• Product Name: 3-AMINO-4-BROMOPHENOL
• Synonyms: 3-AMINO-4-BROMOPHENOL;4-BroMo-3-aMinophenol;Phenol, 3-aMino-4-broMo-;3-AMINO-4-BROMOPHENO
• CAS NO: 100367-37-1
• Molecular Formula: C₆H₆BrNO
• Molecular Weight: 188.023
• Product Categories: Aromatic Halides (substituted)
• Mol File: 100367-37-1.mol

Chemical Properties

• Boiling Point: 300.1 °C at 760 mmHg
• Flash Point: 135.3 °C
• Appearance: /
• Density: 1.768
• Vapor Pressure: 0.000642mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 9.45±0.18(Predicted)
• CAS DataBase Reference: 3-AMINO-4-BROMOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-4-BROMOPHENOL(100367-37-1)
• EPA Substance Registry System: 3-AMINO-4-BROMOPHENOL(100367-37-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 100367-37-1(Hazardous Substances Data)

Usage

Uses

Used in Dye Production:
3-Amino-4-bromophenol is utilized as a key intermediate in the synthesis of various dyes, contributing to the coloration and stability of these products in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 3-Amino-4-bromophenol serves as a crucial intermediate for the development of certain medications, playing a significant role in the synthesis of active pharmaceutical ingredients.
Used in Organic Synthesis:
As an intermediate in organic synthesis, 3-Amino-4-bromophenol is employed in the preparation of a range of organic compounds, facilitating the creation of new chemical entities for various applications.

InChI:InChI=1/C6H6BrNO/c7-5-2-1-4(9)3-6(5)8/h1-3,9H,8H2

Upstream product

• 59557-92-5 2-bromo-5-methoxyaniline 
• 78137-76-5 4-bromo-3-nitrophenol 
• 591-27-5 m-Hydroxyaniline 

Downstream Products

• 591-27-5 m-Hydroxyaniline 
• 1155270-72-6 7-bromo-2,3-dihydropyrano[4,3,2-de]quinoline 
• 1155419-89-8 2-(tert-butoxy)-2-((R)-4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid 
• 1155270-71-5 7-bromo-5-chloro-2,3-dihydropyrano[4,3,2-de]quinoline 
• 1155270-69-1 8-bromo-5-hydroxy-4-(2-hydroxyethyl)quinolin-2(1H)-one 
• 1402714-51-5 methyl 2-(tert-butoxy)-2-((R)-4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetate 
• 1402714-51-5 methyl 2-(tert-butoxy)-2-((S)-4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetate 
• 1609581-21-6 5-(furo[3,2-c]pyridin-4-yloxy)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 1609581-20-5 2-bromo-5-(furo[3,2-c]pyridin-4-yloxy)aniline 
• 1005782-80-8 N-[6-(3-amino-4-bromophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide 

Relevant articles and documents

Discovery of meta-amido bromophenols as new antitubercular agents

A series of meta-amido bromophenol derivatives were designed and synthesized. The compounds were found to potently inhibit the growth of Mycobacterium tuberculosis H37Ra. They also exhibited moderate inhibitory activity against Mycobacterium tuberculosis H37Rv and multidrug-resistant strains. The compounds did not show inhibitory activity against normal Gram-positive and Gram-negative bacteria. Moderate cytotoxicities and good metabolic stability were observed for the selected compounds. The results demonstrated meta-amido bromophenols as a new class of antitubercular agents with good potentials.

3 - Amino - 4 - bromophenol synthetic method

The invention relates to a method for synthesizing 3-amino-4-bromophenol. The method comprises the following steps of: (1) diazotization reaction: dissolving 3-nitro-4-aminophenol used as a raw material into hydrobromic acid, and dropping a sodium nitrite aqueous solution at 0-10 DEG C for reacting for 1-3 hours to obtain a 3-nitrophenol-4-diazonium brine solution; (2) bromination reaction: dropping the solution obtained in the step (1) into a hydrobromic acid aqueous solution of cuprous bromide, stirring at 40-50 DEG C for reacting, and crystallizing and filtering to obtain a 3-nitro-4-bromophenol solid; and (3) reduction reaction: dissolving the solid obtained in the step (2) into alcohol, adding an iron oxide catalyst, heating up to 50-100 DEG C, and adding a hydrazine hydrate aqueous solution to the mixture for reacting for 2-5 hours to obtain the 3-amino-4-bromophenol. The synthesis method of the 3-amino-4-bromophenol has the advantages of reasonable design, moderate condition, easiness of operation and higher product yield and is suitable for industrial production.

Polymer-anchored peroxo compounds of molybdenum and tungsten as efficient and versatile catalysts for mild oxidative bromination

A polymer supported peroxomolybdate(VI) compound of the type [MoO 2(O2)(CN)2]-PAN [PAN = poly(acrylonitrile)] (PANMo) was obtained by reacting H2MoO4 with 30% H 2O2 and the macromolecular ligand, PAN at near neutral pH. The macrocomplex has been characterized by elemental analysis (CHN and EDX analysis), spectral (IR, UV-Vis and 13C NMR, 95Mo NMR), thermal (TGA-DTG) as well as SEM studies. The catalytic activity of PANMo and its previously reported tungsten containing analog PANW, in oxidative bromination of organic substrates has been explored. The supported complexes could serve as efficient heterogeneous catalysts for the oxidative bromination of a variety of structurally diverse aromatic compounds, with H 2O2 as terminal oxidant, to afford bromo organics in impressive yields under environmentally clean conditions. The catalysts afforded regeneration and could be reused for a minimum of six reaction cycles.