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1003887-62-4

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1003887-62-4 Usage

General Description

(S)-8-Fluorochroman-4-amine, also known as 4-amino-8-fluorochroman, is a chemical compound with the molecular formula C9H9NOF. It is a derivative of fluorochroman and is used in the field of medicinal chemistry as a building block for the synthesis of various pharmaceutical compounds. The compound has potential therapeutic applications in the treatment of neurological disorders and other medical conditions. It is also used as a starting material for the synthesis of novel drug candidates. Its unique chemical structure and properties make it a valuable tool in drug discovery and development efforts.

Check Digit Verification of cas no

The CAS Registry Mumber 1003887-62-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,3,8,8 and 7 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1003887-62:
(9*1)+(8*0)+(7*0)+(6*3)+(5*8)+(4*8)+(3*7)+(2*6)+(1*2)=134
134 % 10 = 4
So 1003887-62-4 is a valid CAS Registry Number.

1003887-62-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (4S)-8-fluoro-3,4-dihydro-2H-chromen-4-amine

1.2 Other means of identification

Product number -
Other names (4S)-8-fluoro-3,4-dihydro-2H-1-benzopyran-4-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1003887-62-4 SDS

1003887-62-4Downstream Products

1003887-62-4Relevant articles and documents

2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors

Cole, Andrew G.,Bohnstedt, Adolph C.,Paradkar, Vidyadhar,Kingsbury, Celia,Quintero, Jorge G.,Park, Haengsoon,Lu, Yingchun,You, Ming,Neagu, Irina,Diller, David J.,Letourneau, Jeffrey J.,Shao, Yuefei,James, Ray A.,Riviello, Christopher M.,Ho, Koc-Kan,Lin, Tsung H.,Wang, Bojing,Appell, Kenneth C.,Sills, Matthew,Quadros, Elizabeth,Kimble, Earl F.,Ohlmeyer, Michael H.J.,Webb, Maria L.

scheme or table, p. 6788 - 6792 (2010/06/12)

A novel class of Janus tyrosine kinase 3 (JAK3) inhibitors based on a 2-benzimidazoylpurinone core structure is described. Through substitution of the benzimidazoyl moiety and optimization of the N-9 substituent of the purinone, compound 24 was identified incorporating a chroman-based functional group. Compound 24 shows excellent kinase activity, good oral bioavailability and demonstrates efficacy in an acute mechanistic mouse model through inhibition of interleukin-2 (IL-2) induced interferon-γ (INF-γ) production.

7-Substituted Purine Derivatives for Immunosuppression

-

, (2008/12/05)

The present invention provides novel purinone and related derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formula III:

PURINE AND IMIDAZOPYRIDINE DERIVATIVES FOR IMMUNOSUPPRESSION

-

Page/Page column 97-98, (2010/11/24)

The present invention provides novel purine and imidazopyridine derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulas ( I ) and ( II ).

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