1004-14-4

Basic information

• Product Name: 4-Isopropylmorpholine
• Synonyms: Morpholine, 4-(1-methylethyl)-;4-(1-Methylethyl)morpholine;4-Isopropylmorpholine;4-propan-2-ylmorpholine;N-isopropylmorpholine
• CAS NO: 1004-14-4
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2
• Mol File: 1004-14-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 156.3 °C at 760 mmHg
• Flash Point: 41.7 °C
• Appearance: White or off-white crystal powder
• Density: 0.918 g/cm³
• Vapor Pressure: 2.91mmHg at 25°C
• Refractive Index: 1.445
• CAS DataBase Reference: 4-Isopropylmorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Isopropylmorpholine(1004-14-4)
• EPA Substance Registry System: 4-Isopropylmorpholine(1004-14-4)

Safety Data

• Hazardous Substances Data: 1004-14-4(Hazardous Substances Data)

Usage

General Description

4-Isopropylmorpholine, also known as 4-(1-methylethyl)morpholine, is a chemical compound with a molecular formula of C7H15NO. It is a colorless liquid with a distinct amine odor, and it is commonly used as a solvent in various industrial applications. 4-Isopropylmorpholine is also used as an intermediate in the production of pharmaceuticals, pesticides, and other organic compounds. It has a relatively low acute toxicity, but prolonged exposure to the chemical may cause irritation to the skin, eyes, and respiratory system. 4-Isopropylmorpholine is typically stored and handled in accordance with standard safety precautions to minimize the risk of exposure and adverse health effects.

InChI:InChI=1/C7H15NO/c1-7(2)8-3-5-9-6-4-8/h7H,3-6H2,1-2H3

Upstream product

• 110-91-8 morpholine 
• 67-64-1 acetone 
• 108-20-3 di-isopropyl ether 
• 93627-56-6 4-Isopropyl-4-methyl-morpholin-4-ium; iodide 
• 54022-76-3 2-chloro-1-(4-morpholino)propan-1-one 
• 73086-84-7 1-isopropyl-2,4,6-triphenylpyridin-1-ium tetrafluoroborate salt 
• 121-93-7 N,N-bis(2-hydroxyethyl)isopropylamine 
• 35666-81-0 2-methyl-2-(morpholin-4-yl)propanenitrile 

Relevant articles and documents

Reductive amination of ketones/aldehydes with amines using BH3N(C2H5)3as a reductant

Herein, we report the first example of efficient reductive amination of ketones/aldehydes with amines using BH3N(C2H5)3 as a catalyst and a reductant under mild conditions, affording various tertiary and secondary amines in excellent yields. A mechanistic study indicates that BH3N(C2H5)3 plays a dual function role of promoting imine and iminium formation and serving as a reductant in reductive amination. This journal is

Kinetics and Mechanisms of Nucleophilic Displacements with Heterocycles as Leaving Groups. Part 22. Reactions with Various Nucleophiles and a Study of the Effects of Substrate Concentrations, Traces of Water, ands Nature of the Gegenion on the Rates

First- and second-order rate components for the nucleophilic displacements of a variety of N-(primary alkyl), N-(secondary alkyl), and N-benzyl substituents from mono-, bi-, and tri-cyclic pyridine leaving groups by various nucleophiles are independent of substrate concentration, of the nature of the gegenion, and of traces of water in the solvent.Thus assumptions implicit in the reasoning of earlier papers of this series are confirmed, and the conclusion that these nucleophilic displacements can proceed by five independent mechanistic pathways is strengthened.First-order rate components are invariant with the nature of the nuclephile.Second-order rate components vary with nucleophile nucleophilicity in a way that parallels Menschutkin reactions.Activation enthalpies for first-order components are less negative than those for second-order components, in agreement with previous data.

Reductive Rearrangement of 2-Chloroalkanamides with Lithium Aluminum Hydride Leading to α-Methyl-Branched Aliphatic Amines

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