1004-75-7Relevant articles and documents
Synthesis of 7-methyl-6-indolopterin and 7-methyl-6-indoloquinoxaline
Goswami, Shyamaprosad,Das, Manas Kumar,Maity, Annada C.,Quah, Ching Kheng,Fun, Hoong-Kun
, p. 1529 - 1536 (2016)
The first syntheses of indolopterin and indoloquinoxaline, two important and dissimilar diheterocycles linking C-2 of indole with C-6 of pterin (significant positions for showing biological activity), and quinoxaline, respectively, have been achieved base
PREPARATION OF 5-AMINO-7(6H)-FURAZANOPYRIMIDINONE AN ANALOG OF PTERIN
Boyle, Peter H.,Lockhart, Ronan J.
, p. 879 - 886 (1984)
5-Aminofurazanopyrimidines carrying a variety of substituents at position 7 suffer ring cleavage by either acid or base to give 4-guanidino-3-furazancarboxylic acid (6), the esters of which can be recyclised to give the pterin analog 5-amino-7(6H)-
Synthesis process, intermediate and pharmaceutical process of 2, 4, 5-triamino-6-hydroxypyrimidine
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Paragraph 0037-0042, (2021/08/07)
The invention discloses a synthesis process of 2, 4, 5-triamino-6-hydroxypyrimidine, which comprises the following steps: 1) carrying out pressurized catalytic hydrogenation reaction on liquid 2-nitroso and 2-methyl cyanoacetate/ethyl cyanoacetate to generate 2-amino and 2-cyanoacetic acid methyl ester/ethyl ester; (2) carrying out cyclization reaction on the 2-amino, 2-methyl cyanoacetate/ethyl cyanoacetate and free guanidine to generate 2, 4, 5-triamino-6-hydroxypyrimidine; wherein the liquid 2-nitroso and 2-methyl cyanoacetate/ethyl cyanoacetate in the step 1) are generated by carrying out nitrosation reaction on methyl cyanoacetate/ethyl cyanoacetate and sodium nitrite. The invention also discloses intermediates 2-nitroso and 2-methyl cyanoacetate in the synthesis process, a synthesis process of the intermediates, and a pharmaceutical process taking the 2, 4, 5-triamino-6-hydroxypyrimidine as an intermediate. According to the present invention, the liquid new compounds such as 2-nitroso and 2-methyl cyanoacetate/ethyl cyanoacetate are subjected to the catalytic hydrogenation reaction, such that the problems of large water consumption and large wastewater yield in the 2, 4, 5-triamino-6-hydroxypyrimidine synthesis process can be solved, and the great economic significance and the great environmental protection significance are provided.
Triaminopyrimimelamino 2, 4, 5- pyrimidine formate -6- and preparation method and application thereof
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Paragraph 0055-0058; 0067-0070, (2019/11/29)
The invention discloses 2,4,5-triamido-6-hydroxy pyrimidine formate and a preparation method. The preparation method comprises the following steps: enabling 2,4-diamido-5-nitro-6-hydroxy pyrimidine toreact with hydrogen in catalyst A and alkaline solution B, and obtaining 2,4,5-triamido-6-hydroxyl pyrimidine; and enabling a hydrogenation product to perform the salt forming reaction with formic acid to obtain 2,4,5-triamido-6-hydroxy pyrimidine formate. The invention discloses a method for preparing guanine by utilizing the 2,4,5-triamido-6-hydroxy pyrimidine formate. The preparation method isshort in production route, and high in molar yield, wherein the total molar yield is 90 percent or higher. The solvent can be recycled and generally used, the content of the salt and strong acid in the production wastewater can be greatly reduced, and the emission amount is little. The pyrimidine formate is a brand new compound. The pyrimidine formate is used for substituting the pyrimidine sulfate to prepare the guanine, so that a great amount of sulfate can be prevented from flowing into the production wastewater.