100421-13-4Relevant articles and documents
Substituent Effects of 2-Pyridones on Selective O-Arylation with Diaryliodonium Salts: Synthesis of 2-Aryloxypyridines under Transition-Metal-Free Conditions
Li, Xiao-Hua,Ye, Ai-Hui,Liang, Cui,Mo, Dong-Liang
, p. 1699 - 1710 (2018/02/06)
An efficient transition-metal-free strategy to synthesize 2-aryloxypyridine derivatives has been developed by a selective O-arylation of 2-pyridones with diaryliodonium salts. The reaction was compatible with a series of functional groups for 2-pyridones and diaryliodonium salts such as halides, nitro, cyano, and ester groups. The substituents at the C6-position of 2-pyridones favored O-arylation products because of steric hindrance. The reaction was easily performed on a gram-scale and 6-chloro-2-pyridone was a good precursor to access various unsubstituted 2-aryloxypyridines by dehalogenation. A P2Y 1 lead compound analogue could be prepared in good yield over two steps.
THE REACTION OF 2,2'-DIPYRIDYL SULFIDE WITH PHENOL
Inoue, Shordoh
, p. 141 - 144 (2007/10/02)
The reaction of 2,2'-dipyridyl sulfide with phenol affords 2-pyridinethiol and phenyl 2-pyridyl ether, which is the aromatic ipso substitution in 2,2'-dipyridyl sulfide by the phenoxy group.On the other hand, pyridyl tolyl sulfide is formed by the reaction of phenyl pyridyl ether with toluenethiol.
