1005-33-0

Basic information

• Product Name: (4-chlorophenyl)phosphonous dichloride
• CAS NO: 1005-33-0
• Molecular Formula: C₆H₄Cl₃P
• Molecular Weight: 213.4287
• Mol File: 1005-33-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 258.1°C at 760 mmHg
• Flash Point: 109.9°C
• Vapor Pressure: 0.0226mmHg at 25°C
• CAS DataBase Reference: (4-chlorophenyl)phosphonous dichloride(CAS DataBase Reference)
• NIST Chemistry Reference: (4-chlorophenyl)phosphonous dichloride(1005-33-0)
• EPA Substance Registry System: (4-chlorophenyl)phosphonous dichloride(1005-33-0)

Safety Data

• Hazardous Substances Data: 1005-33-0(Hazardous Substances Data)

Usage

General Description

(4-chlorophenyl)phosphonous dichloride, also known as chlorophenylphosphine dichloride, is a chemical compound with the molecular formula C6H4ClPCl2. It is a phosphorus-containing compound with two chlorine atoms and a phenyl group attached to a phosphonous acid moiety. (4-chlorophenyl)phosphonous dichloride is commonly used as a reagent in organic synthesis, particularly in the preparation of phosphine ligands for transition metal catalysts. It is a versatile building block in the production of a wide variety of phosphorous-containing compounds. (4-chlorophenyl)phosphonous dichloride is a highly reactive and hazardous chemical and should be handled with extreme caution due to its corrosive and toxic nature.

Upstream product

• 108-90-7 chlorobenzene 
• 89523-62-6 (4-chlorophenyl)zinc(II) chloride 
• 4731-53-7 TOP 
• 22585-81-5 4-chlorophenylphosphonoyl dichloride 
• 106-39-8 bromochlorobenzene 
• 1005-34-1 p-chlorophenylphosphonous acid 

Downstream Products

• 35455-05-1 (4-Chlor-phenyl)-phosphonigsaeure-bis-(2-chlor-ethylester) 
• 70430-43-2 p-chlorophenylphosphonous dibromide 
• 67074-88-8 p-Chlorophenyl dichloroselenophosphonate 
• 1005-34-1 p-chlorophenylphosphonous acid 
• 138971-42-3 C₄₄H₃₄ClPS₂ 
• 38080-07-8 [(4-Chloro-phenyl)-ethoxycarbonylmethyl-phosphanyl]-acetic acid ethyl ester 
• 95174-87-1 2-(4-chloro-phenyl)-4,5-diethoxy-2H-[1,3,2]diazaphosphole 
• 32504-02-2 2-(4-chloro-phenyl)-3,3,5-trimethyl-2,3-dihydro-[1,2]oxaphosphole 2-oxide 
• 39055-27-1 p-Chlorphenyl-(1-ethoxyethyl)-phosphinsaeurechlorid 
• 90347-42-5 -kohlensaeure-aethylester 
• 91912-22-0 -kohlensaeure-methylester 
• 94764-35-9 1-(4-chloro-phenyl)-2-methyl-2,5-dihydro-1H-phosphole 1-oxide 
• 19909-82-1 <4-Chlor-phenyl>-phosphonigsaeure-dimethylester 
• 1479-01-2 (4-chloro-phenyl)-tetrafluoro-phosphorane 

Relevant articles and documents

The Formation of P-C Bonds Utilizing Organozinc Reagents for the Synthesis of Aryl- A nd Heteroaryl-Dichlorophosphines

Aryl- A nd heteroaryl-dichlorophosphines are mildly and selectively made in a one-pot synthesis in moderate to good yields starting from the respective aryl bromides or five-membered heterocycles, following lithiation with nBuLi, transmetalation with ZnCl

Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals

The present invention relates to 5-membered heterocyclic condensed benzoderivatives of formula wherein Ra to Rc, A, X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable properties. The compounds of the above formula I wherein Rc denotes a cyano group are valuable intermediates for preparing the other compounds of formula I, and the compounds of the above formula I wherein Rc denotes one of the following amidino groups and the tautomers and stereoisomers thereof have valuable pharmacological properties, particularly an antithrombotic activity.

DIARYLPHOSPHINIC AZIDES. PHOTOCHEMICAL REACTIONS INCLUDING REARRANGEMENT IN METHANOL

On photolysis in methanol the diarylphosphinic azides Ar2P(O)N3 (Ar=phenyl, p-tolyl, p-anisyl, p-chlorophenyl) rearrange with loss of nitrogen to form (monomeric) metaphosphonimidates which are trapped by the solvent to give methyl NP-diarylphosphonamidates (7) (41-53percent).Diarylphosphinic amides (18-42percent) are also usually formed, presumably from (triplet) nitrenes.The limited evidence available suggests that the rearrangements take place directly from the photo-excited azides rather than via (singlet) nitrene intermediates.One of the products of rearrangement, methyl NP-di(p-chlorophenyl)phosphonamidate, suffers extensive photochemical dechlorination giving methyl N-phenyl-P-p-chlorophenylphosphonamidate.