1008-30-6

Basic information

• Product Name: 2,4-Dihydro-4-phenyl-3H-1,2,4-triazol-3-one
• Synonyms: 2,4-Dihydro-4-phenyl-3H-1,2,4-triazol-3-one;4-phenyl-1H-1,2,4-triazol-5-one;4,5-Dihydro-5-oxo-4-phenyl-1H-1,2,4-triazole, (1,5-Dihydro-5-oxo-4H-1,2,4-triazol-4-yl)benzene
• CAS NO: 1008-30-6
• Molecular Formula: C₈H₇N₃O
• Molecular Weight: 161.16
• Mol File: 1008-30-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 184-186°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.32g/cm³
• Refractive Index: 1.665
• PKA: 9.48±0.20(Predicted)
• CAS DataBase Reference: 2,4-Dihydro-4-phenyl-3H-1,2,4-triazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dihydro-4-phenyl-3H-1,2,4-triazol-3-one(1008-30-6)
• EPA Substance Registry System: 2,4-Dihydro-4-phenyl-3H-1,2,4-triazol-3-one(1008-30-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 1008-30-6(Hazardous Substances Data)

Usage

General Description

2,4-Dihydro-4-phenyl-3H-1,2,4-triazol-3-one, also known as aphidicolin, is a chemical compound with the molecular formula C11H10N4O. It is a synthetic derivative of triazolone and is commonly used as a reversible inhibitor of DNA polymerase alpha and delta. Aphidicolin has been studied for its potential antiviral and anticancer properties due to its ability to block cell division and DNA replication. It has also been used in research to study DNA synthesis and repair mechanisms. However, it is important to handle this compound with caution as it is toxic and should be used only by trained professionals in a controlled laboratory setting.

InChI:InChI=1/C8H7N3O/c12-8-10-9-6-11(8)7-4-2-1-3-5-7/h1-6H,(H,10,12)

Upstream product

• 6294-89-9 hydrazinecarboxylic acid methyl ester 
• 62-53-3 aniline 
• 149-73-5 trimethyl orthoformate 
• 537-47-3 4-phenyl-semicarbazide 
• 912482-18-9 (E)-N'-(ethoxymethylene)hydrazinecarboxylic acid methyl ester 
• 36215-90-4 4-phenyl-1-formylsemicarbazide 
• 98292-45-6 (E)-1-Ethoxymethylene-4-phenylsemicarbazide 
• 4930-03-4 phenyl N-phenylcarbamate 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 1140826-17-0 1-[(2,4-dioxothiazolidin-5-yl)acetyl]-5-oxo-4-phenyl-4,5-dihydro-1,2,4-triazole 
• 1312809-80-5 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-4-phenyl-1H-1,2,4-triazol-5(4H)-one 
• 1346235-28-6 C₁₅H₂₁N₅O 
• 1346235-48-0 1-(3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl) piperazin-1-yl)propyl)-4-phenyl-1H-1,2,4-triazol-5(4H)-one 

Relevant articles and documents

Rearrangement of 1-aminoimidazolidine-4,5-triones to 5-oxo-4,5-dihydro-1,2, 4-triazole-3-carboxylic acid

-

Dammarane sapogenin derivative and preparation method and application thereof

The invention belongs to the technical field of medicines, and relates to a dammarane sapogenin derivative and a preparation method and application thereof. A series of dammarane sapogenin derivativesare obtained by combining dammarane sapogenins from plants with different groups. Anticancer activity evaluation and anticancer activity mechanism research are carried out on the derivative, and results show that the prepared dammarane sapogenin derivative has a remarkable anticancer effect, has no toxic effect on normal cells and can be used for preparing drugs for treating cancers.

Design, synthesis, and negative inotropic evaluation of 4-phenyl-1H-1,2,4-triazol-5(4H)-one derivatives containing triazole or piperazine moieties

In this study, four novel series of 4-phenyl-1H-1,2,4-triazol-5(4H)-one derivatives containing triazole or piperazine moieties were designed, synthesized, and evaluated for negative inotropic activity by measuring the left atrium stroke volume in isolated rabbit heart preparations. Almost all of the compounds showed an ability to moderate the cardiac workload by decreasing the heart rate and contractility. Among them, 7h was found to be the most potent with a change in stroke volume of ?48.22?±?0.36% at a concentration of 3?×?10?5?mol/L (metoprolol: ?9.74?±?0.14%). The cytotoxicity of these compounds was evaluated using the human cervical cancer cell line HeLa, the liver cancer cell line Hep3B, and the human normal hepatic cell line LO2. A preliminary study of the mechanism of action for the compound 7h on the regulation of atrial dynamics with ATP-sensitive K+ channel and L-type Ca2+ channel blockers glibenclamide and nifedipine was performed in the isolated perfused beating rabbit atria.