1008139-25-0

Basic information

• Product Name: ISOXAZOL-4-YLBORONIC ACID
• Synonyms: ISOXAZOL-4-YLBORONIC ACID
• CAS NO: 1008139-25-0
• Molecular Formula: C3H4BNO3
• Molecular Weight: 112.88
• Mol File: 1008139-25-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: ISOXAZOL-4-YLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: ISOXAZOL-4-YLBORONIC ACID(1008139-25-0)
• EPA Substance Registry System: ISOXAZOL-4-YLBORONIC ACID(1008139-25-0)

Safety Data

• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 1008139-25-0(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
Isoxazol-4-ylboronic acid is used as a synthetic intermediate for the development of pharmaceutical compounds. Its unique structure allows for the creation of complex molecules that can be utilized in the design of new drugs and therapeutic agents.
Used in Organic Chemistry:
In the field of organic chemistry, Isoxazol-4-ylboronic acid is employed as a reagent in various chemical reactions. Its boronic acid functionality enables it to participate in reactions such as the Suzuki-Miyaura cross-coupling, which is a widely used method for the formation of carbon-carbon bonds. This makes it a valuable tool for the synthesis of complex organic molecules and the development of novel chemical structures.
Used in Scientific Research:
Isoxazol-4-ylboronic acid is used as a research chemical in academic and industrial laboratories. Its properties and reactivity are studied to gain insights into the behavior of boronic acids and their potential applications in various fields, including materials science, catalysis, and chemical biology.

Upstream product

• 97925-43-4 4-bromo-1,2-oxazole 
• 847490-69-1 4-iodoisoxazole 
• 121-43-7 Trimethyl borate 

Downstream Products

• 928664-98-6 4-isoxazoleboronic acid pinacol ester 

Relevant articles and documents

Generation of an 4-Isoxazolyl Anion Species: Facile Access to Multifunctionalized Isoxazoles

A direct functionalization of unsubstituted isoxazole (1) was achieved by generation of 4-isoxazolyl anion species (3). An efficient 4-iodination of isoxazole and halogen–metal exchange reaction using a turbo Grignard reagent (iPrMgCl? LiCl) were essentia

Palladium-catalyzed cyanomethylation of aryl halides through domino Suzuki coupling-isoxazole fragmentation

A one-pot protocol for the cyanomethylation of aryl halides through a palladium-catalyzed reaction with isoxazole-4-boronic acid pinacol ester was developed. Mechanistically, the reaction proceeds through (1) Suzuki coupling, (2) base-induced fragmentation, and (3) deformylation as shown by characterization of all postulated intermediates. Under optimized conditions (PdCl2dppf, KF, DMSO/H2O, 130 °C) a broad spectrum of aryl bromides could be converted into arylacetonitriles with up to 88% yield.

ORGANIC COMPOUNDS

Compounds of formula (I) in free or salt or solvate form, where T1, T2, X, Ra, Rb, R8 and R9 have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.