100858-33-1

Basic information

• Product Name: (R)-1-CBZ-3-PYRROLIDINOL
• Synonyms: (R)-(-)-1-CBZ-3-HYDROXY-PYRROLIDINE ;(R)-benzyl 3-hydroxypyrrolidine-1-carboxylate;(R)-N-Cbz-3-hydroxypyrrolidine;(R)-3-Hydroxy-pyrrolidine-1-carboxylic acid benzyl ester;N-Cbz-3(R)-hydroxypyrrolidine;(R)-1-Benzyloxycarbonyl-3-pyrrolidinol, (R)-1-Carbobenzoxy-3-pyrrolidinol, (R)-N-Z-3-Pyrrolidinol;(R)-(-)-1-Cbz-3-pyrrolidinol;(R)-1-Cbzl-3-pyrrolidinol
• CAS NO: 100858-33-1
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.2524
• Mol File: 100858-33-1.mol
• Article Data: 28

Chemical Properties

• Melting Point: 74-79 °C
• Boiling Point: 370.7 °C at 760 mmHg
• Flash Point: 178 °C
• Appearance: /
• Density: 1.263 g/cm³
• Vapor Pressure: 3.75E-06mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Chloroform
• PKA: 14.72±0.20(Predicted)
• CAS DataBase Reference: (R)-1-CBZ-3-PYRROLIDINOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-CBZ-3-PYRROLIDINOL(100858-33-1)
• EPA Substance Registry System: (R)-1-CBZ-3-PYRROLIDINOL(100858-33-1)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 100858-33-1(Hazardous Substances Data)

Usage

Chemical Properties

White to brown crystal to powder

InChI:InChI=1/C12H15NO3/c14-11-6-7-13(8-11)12(15)16-9-10-4-2-1-3-5-10/h1-5,11,14H,6-9H2/t11-/m1/s1

Upstream product

• 31970-04-4 1-carboxybenzyl-3-pyrrolidine 
• 501-53-1 benzyl chloroformate 
• 122536-94-1 (S)-3-hydroxypyrrolidine hydrochloride 
• 25070-74-0 1-benzyloxycarbonylpyrrolidine 
• 130312-02-6 benzyl 3-oxopyrrolidine-1-carboxylate 
• 95656-88-5 benzyl 3-hydroxypyrrolidine-1-carboxylate 
• 174621-88-6 (S)-3-(acetyloxy)-1-pyrrolidinecarboxylic acid, phenylmethyl ester 
• 40499-83-0 (3R)-pyrrolidinol 
• 104706-47-0 (R)-3-hydroxypyrrolidine hydrochloride 
• 108-22-5 Isopropenyl acetate 

Downstream Products

• 136725-51-4 benzyl (3R)-3-(p-tolylsulfonyloxy)pyrrolidine-1-carboxylate 
• 130403-93-9 (S)-benzyl 3-acetoxypyrrolidine-1-carboxylate 
• 960508-13-8 (S)-N-benzyloxycarbonyl-3-trifluoroacetoxypyrrolidine 
• 31970-04-4 1-carboxybenzyl-3-pyrrolidine 
• 136725-52-5 (S)-N-CBz-3-fluoropyrrolidine 
• 1316848-03-9 (S)-benzyl 3-(((S)-1-(tert-butoxy)-1-oxopropan-2-yl)amino)pyrrolidine-1-carboxylate 
• 1316847-95-6 (S)-benzyl 3-(((S)-1-(tert-butoxy)-1-oxo-3-phenylpropan-2-yl)amino)pyrrolidine-1-carboxylate 
• 1316848-05-1 C₂₂H₃₄N₂O₄ 
• 1316847-99-0 (S)-benzyl 3-(((S)-1-(tert-butoxy)-1-oxo-3-phenylpropan-2-yl)amino)pyrrolidine-1-carboxylate hydrochloride 
• 1316848-04-0 C₁₉H₂₈N₂O₄*ClH 
• 150931-62-7 (R)-1-benzyloxycarbonyl-3-(t-butyldimethylsilyloxy)pyrrolidine 
• 122536-68-9 (R)-3-<(methylsulfonyl)oxy>-1-pyrrolidinecarboxylic acid phenylmethyl ester 

Relevant articles and documents

NOVEL HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE BCR-ABL INHIBITORS

Disclosed is a compound of Formula (Ⅰ) or a pharmaceutically acceptable salt thereof, wherein the variables are described herein. Also disclosed is a process for the preparation of compounds, their pharmaceutical compositions comprising the same as an active ingredient, methods using said compositions in the treatment of various disorders, and use of the compounds in the manufacture of a medicament in inhibition of the enzymatic activities of ABL1, ABL2 and related chimeric proteins.

Ultrafast chiral separations for high throughput enantiopurity analysis

Recent developments in fast chromatographic enantioseparations now make high throughput analysis of enantiopurity on the order of a few seconds achievable. Nevertheless, routine chromatographic determinations of enantiopurity to support stereochemical investigations in pharmaceutical research and development, synthetic chemistry and bioanalysis are still typically performed on the 5-20 min timescale, with many practitioners believing that sub-minute enantioseparations are not representative of the molecules encountered in day to day research. In this study we develop ultrafast chromatographic enantioseparations for a variety of pharmaceutically-related drugs and intermediates, showing that sub-minute resolutions are now possible in the vast majority of cases by both supercritical fluid chromatography (SFC) and reversed phase liquid chromatography (RP-LC). Examples are provided illustrating how such methods can be routinely developed and used for ultrafast high throughput analysis to support enantioselective synthesis investigations.

An efficient dynamic kinetic resolution of N-heterocyclic 1,2-amino alcohols

A chemoenzymatic dynamic kinetic resolution (DKR) of N-heterocyclic amino alcohols is described. Various lipases were studied as biocatalysts for the kinetic resolution of N-heterocyclic 1,2-amino alcohols. The influence of the support of the enzymes on t