Welcome to LookChem.com Sign In|Join Free

Cas Database

100858-33-1

100858-33-1

Identification

  • Product Name:1-Pyrrolidinecarboxylicacid, 3-hydroxy-, phenylmethyl ester, (3R)-

  • CAS Number: 100858-33-1

  • EINECS:

  • Molecular Weight:221.256

  • Molecular Formula: C12H15NO3

  • HS Code:29339900

  • Mol File:100858-33-1.mol

Synonyms:1-Pyrrolidinecarboxylicacid, 3-hydroxy-, phenylmethyl ester, (R)-;(R)-1-Benzyloxycarbonyl-3-pyrrolidinol;Benzyl (3R)-3-hydroxy-1-pyrrolidinecarboxylate;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Pictogram(s):ToxicT

  • Hazard Codes:T

  • Signal Word:Danger

  • Hazard Statement:H301 Toxic if swallowedH315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:(R)-(-)-1-Cbz-3-pyrrolidinol
  • Packaging:100mg
  • Price:$ 75
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:(R)-1-Carbobenzoxy-3-pyrrolidinol >98.0%(GC)
  • Packaging:5g
  • Price:$ 207
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:(R)-1-Carbobenzoxy-3-pyrrolidinol >98.0%(GC)
  • Packaging:1g
  • Price:$ 42
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:(R)-1-Cbz-3-hydroxypyrrolidine
  • Packaging:1 g
  • Price:$ 38
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:(R)-1-Cbz-3-hydroxypyrrolidine
  • Packaging:5 g
  • Price:$ 58
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:(R)-1-Cbz-3-hydroxypyrrolidine
  • Packaging:25 g
  • Price:$ 150
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:(R)-(?)-1-Cbz-3-pyrrolidinol 95%
  • Packaging:5g
  • Price:$ 352
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:(R)-(?)-1-Cbz-3-pyrrolidinol 95%
  • Packaging:1g
  • Price:$ 93.1
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Oakwood
  • Product Description:(R)-(-)-1-Cbz-3-Hydroxy-pyrrolidine
  • Packaging:5g
  • Price:$ 20
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Oakwood
  • Product Description:(R)-(-)-1-Cbz-3-Hydroxy-pyrrolidine
  • Packaging:1g
  • Price:$ 10
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 28 Articles be found

NOVEL HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE BCR-ABL INHIBITORS

-

Page/Page column 43; 44, (2017/12/09)

Disclosed is a compound of Formula (Ⅰ) or a pharmaceutically acceptable salt thereof, wherein the variables are described herein. Also disclosed is a process for the preparation of compounds, their pharmaceutical compositions comprising the same as an active ingredient, methods using said compositions in the treatment of various disorders, and use of the compounds in the manufacture of a medicament in inhibition of the enzymatic activities of ABL1, ABL2 and related chimeric proteins.

Stereo-complementary bioreduction of saturated N-heterocyclic ketones

Li, Chao,Liu, Yan,Pei, Xiao-Qiong,Wu, Zhong-Liu

, p. 90 - 97 (2017/04/28)

The asymmetric bioreduction of several saturated N-heterocyclic ketones is demonstrated in a stereo-complementary fashion using the ketoreductases READH and ChKRED20 for the production of (S)- and (R)-alcohols, respectively. The reaction accepts substrates with a five-, six- or seven-membered ring, and exhibits excellent stereoselectivity when using 2-propanol as both the ultimate reducing agent and cosolvent, achieve >99% ee in the majority of cases for both enantiomers.

Ultrafast chiral separations for high throughput enantiopurity analysis

Barhate, Chandan L.,Joyce, Leo A.,Makarov, Alexey A.,Zawatzky, Kerstin,Bernardoni, Frank,Schafer, Wes A.,Armstrong, Daniel W.,Welch, Christopher J.,Regalado, Erik L.

supporting information, p. 509 - 512 (2017/01/13)

Recent developments in fast chromatographic enantioseparations now make high throughput analysis of enantiopurity on the order of a few seconds achievable. Nevertheless, routine chromatographic determinations of enantiopurity to support stereochemical investigations in pharmaceutical research and development, synthetic chemistry and bioanalysis are still typically performed on the 5-20 min timescale, with many practitioners believing that sub-minute enantioseparations are not representative of the molecules encountered in day to day research. In this study we develop ultrafast chromatographic enantioseparations for a variety of pharmaceutically-related drugs and intermediates, showing that sub-minute resolutions are now possible in the vast majority of cases by both supercritical fluid chromatography (SFC) and reversed phase liquid chromatography (RP-LC). Examples are provided illustrating how such methods can be routinely developed and used for ultrafast high throughput analysis to support enantioselective synthesis investigations.

CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY

-

Page/Page column 57, (2012/01/06)

The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

An efficient dynamic kinetic resolution of N-heterocyclic 1,2-amino alcohols

Lihammar, Richard,Millet, Renaud,Baeckvall, Jan-E.

supporting information; scheme or table, p. 2321 - 2327 (2011/10/19)

A chemoenzymatic dynamic kinetic resolution (DKR) of N-heterocyclic amino alcohols is described. Various lipases were studied as biocatalysts for the kinetic resolution of N-heterocyclic 1,2-amino alcohols. The influence of the support of the enzymes on t

Process route upstream and downstream products

Process route

benzyl 3-oxopyrrolidine-1-carboxylate
130312-02-6

benzyl 3-oxopyrrolidine-1-carboxylate

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester
100858-33-1

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

Conditions
Conditions Yield
With recombinant Chryseobacterium sp. CA 49 ketoreductase; nicotinamide adenine dinucleotide; In aq. phosphate buffer; isopropyl alcohol; at 40 ℃; for 24h; pH=7.0; stereoselective reaction; Enzymatic reaction;
84%
benzyl chloroformate
501-53-1,94274-21-2

benzyl chloroformate

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester
100858-33-1

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

Conditions
Conditions Yield
With sodium carbonate; In diethyl ether; water; at 0 - 20 ℃;
98%
With triethylamine; In acetonitrile; at 0 - 20 ℃; for 24h; Inert atmosphere;
98%
In tetrahydrofuran; water;
95%
In tetrahydrofuran; water;
95%
With triethylamine; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;
83%
With triethylamine; In dichloromethane; for 1h; Ambient temperature;
76%
With triethylamine; In dichloromethane;
With triethylamine; In dichloromethane; at 0 ℃; for 2h;
With potassium carbonate; In water; ethyl acetate; cyclohexanol; at 20 ℃; for 0.5h;
83.98 g
With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2.16667 - 3.66667h; Product distribution / selectivity;
With triethylamine; In dichloromethane; at 5 - 20 ℃; for 2.5h;
With triethylamine; In dichloromethane; at 0 - 20 ℃;
With triethylamine; In dichloromethane; at 0 - 20 ℃;
With triethylamine; In dichloromethane; at 5 - 20 ℃;
(R)-3-hydroxypyrrolidine hydrochloride
104706-47-0,111810-68-5

(R)-3-hydroxypyrrolidine hydrochloride

benzyl chloroformate
501-53-1,94274-21-2

benzyl chloroformate

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester
100858-33-1

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

Conditions
Conditions Yield
With sodium hydroxide; at 5 ℃; for 2h;
95%
With triethylamine; In dichloromethane; at 0 ℃; for 2h;
(R)-3-hydroxypyrrolidine hydrochloride; benzyl chloroformate; With triethylamine; In dichloromethane; for 6h;
With hydrogenchloride; In dichloromethane; water;
With triethylamine; In dichloromethane; for 6h;
1-benzyloxycarbonylpyrrolidine
25070-74-0

1-benzyloxycarbonylpyrrolidine

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester
100858-33-1

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

Conditions
Conditions Yield
With D-glucose; Sphingomonas sp. HXN-200; In phosphate buffer; at 30 ℃; for 0.5h; pH=7.5; Enzymatic reaction;
66%
(S)-3-(acetyloxy)-1-pyrrolidinecarboxylic acid, phenylmethyl ester
174621-88-6

(S)-3-(acetyloxy)-1-pyrrolidinecarboxylic acid, phenylmethyl ester

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester
100858-33-1

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

Conditions
Conditions Yield
With phosphate buffer; In 1,4-dioxane; at 25 ℃; for 24h; lipase PS;
44%
benzyl chloroformate
501-53-1,94274-21-2

benzyl chloroformate

(S)-3-hydroxypyrrolidine hydrochloride
122536-94-1,111810-68-5

(S)-3-hydroxypyrrolidine hydrochloride

(S)-3-hydroxy-1-pyrrolidinecarboxylic acid phenylmethyl ester
100858-32-0

(S)-3-hydroxy-1-pyrrolidinecarboxylic acid phenylmethyl ester

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester
100858-33-1

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

Conditions
Conditions Yield
With sodium hydroxide; In water;
benzyl chloroformate
501-53-1,94274-21-2

benzyl chloroformate

(3R)-3-Hydroxypyrrolidium hydrogen maleate

(3R)-3-Hydroxypyrrolidium hydrogen maleate

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester
100858-33-1

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

Conditions
Conditions Yield
With sodium carbonate; In water; at 0 - 25 ℃; for 4.5h; Inert atmosphere;
78%
benzyl 3-hydroxypyrrolidine-1-carboxylate
95656-88-5

benzyl 3-hydroxypyrrolidine-1-carboxylate

(S)-3-hydroxy-1-pyrrolidinecarboxylic acid phenylmethyl ester
100858-32-0

(S)-3-hydroxy-1-pyrrolidinecarboxylic acid phenylmethyl ester

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester
100858-33-1

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

Conditions
Conditions Yield
With carbon dioxide; isobutylamine; In methanol; at 40 ℃; under 150015 Torr; enantioselective reaction; Resolution of racemate;
1-carboxybenzyl-3-pyrrolidine
31970-04-4

1-carboxybenzyl-3-pyrrolidine

(S)-3-hydroxy-1-pyrrolidinecarboxylic acid phenylmethyl ester
100858-32-0

(S)-3-hydroxy-1-pyrrolidinecarboxylic acid phenylmethyl ester

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester
100858-33-1

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

Conditions
Conditions Yield
With sodium hydroxide; sodium tetrahydroborate; dihydrogen peroxide; diisopinocampheylborane; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) 0 deg C, 4 h; 2.) 25 deg C;
benzyl 3-hydroxypyrrolidine-1-carboxylate
95656-88-5

benzyl 3-hydroxypyrrolidine-1-carboxylate

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester
100858-33-1

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: pyridine, DMPA / CH2Cl2 / 4 h / Ambient temperature
2: 44 percent / phosphate buffer (pH 7.0) / dioxane / 24 h / 25 °C / lipase PS
With pyridine; phosphate buffer; 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; In 1,4-dioxane; dichloromethane;

Global suppliers and manufacturers

Global( 84) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:55
  • Country:China (Mainland)
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Shaanxi BLOOM TECH Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-29-86470566
  • Emails:sales@bloomtechz.com
  • Main Products:79
  • Country:China (Mainland)
  • Shanghai Upbio Tech Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-21-52196435
  • Emails:upbiocn@hotmail.com
  • Main Products:87
  • Country:China (Mainland)
  • Siwei Development Group Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-82881840
  • Emails:marksiwei@vip.163.com
  • Main Products:55
  • Country:China (Mainland)
  • Win-Win chemical Co.Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-577-64498589
  • Emails:sales@win-winchemical.com
  • Main Products:55
  • Country:China (Mainland)
  • GIHI CHEMICALS CO.,LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-86217390
  • Emails:info@gihichem.com
  • Main Products:66
  • Country:China (Mainland)
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 100858-33-1
Post Buying Request Now
close
Remarks: The blank with*must be completed