1009092-91-4Relevant articles and documents
Discovery of benzamides as potent human β3 adrenergic receptor agonists
Zhu, Cheng,Kar, Nam F.,Li, Bing,Costa, Melissa,Dingley, Karen H.,Di Salvo, Jerry,Ha, Sookhee N.,Hurley, Amanda L.,Li, Xiaofang,Miller, Randy R.,Salituro, Gino M.,Struthers, Mary,Weber, Ann E.,Hale, Jeffrey J.,Edmondson, Scott D.
, p. 55 - 59 (2015/12/18)
The paper will describe the synthesis and SAR studies that led to the discovery of benzamide (reverse amide) as potent and selective human β3-adrenergic receptor agonist. Based on conformationally restricted pyrrolidine scaffold we discovered e
A process for producing an intermediate agonist GRK 3
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, (2016/10/09)
The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions.
Asymmetric synthesis of cis-2,5-disubstituted pyrrolidine, the core scaffold of β3-AR agonists
Xu, Feng,Chung, John Y. L.,Moore, Jeffery C.,Liu, Zhuqing,Yoshikawa, Naoki,Hoerrner, R. Scott,Lee, Jaemoon,Royzen, Maksim,Cleator, Ed,Gibson, Andrew G.,Dunn, Robert,Maloney, Kevin M.,Alam, Mahbub,Goodyear, Adrian,Lynch, Joseph,Yasuda, Nobuyashi,Devine, Paul N.
supporting information, p. 1342 - 1345 (2013/04/24)
A practical, enantioselective synthesis of cis-2,5-disubstituted pyrrolidine is described. Application of an enzymatic DKR reduction of a keto ester, which is easily accessed through a novel intramolecular N→C benzoyl migration, yields syn-1,2-amino alcoh