1009309-18-5

Basic information

• Product Name: methyl 5-amino-4-{[2-(ethoxycarbonylamino)phenyl]ethynyl}-7-methyl-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
• Synonyms: methyl 5-amino-4-{[2-(ethoxycarbonylamino)phenyl]ethynyl}-7-methyl-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
• CAS NO: 1009309-18-5
• Molecular Weight: 439.495
• Mol File: 1009309-18-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 5-amino-4-{[2-(ethoxycarbonylamino)phenyl]ethynyl}-7-methyl-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-amino-4-{[2-(ethoxycarbonylamino)phenyl]ethynyl}-7-methyl-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate(1009309-18-5)
• EPA Substance Registry System: methyl 5-amino-4-{[2-(ethoxycarbonylamino)phenyl]ethynyl}-7-methyl-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate(1009309-18-5)

Safety Data

• Hazardous Substances Data: 1009309-18-5(Hazardous Substances Data)

Upstream product

• 148550-52-1 ethyl N-(2-ethynylphenyl)carbamate 
• 820210-78-4 methyl 5-amino-4-iodo-7-methyl-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate 

Relevant articles and documents

Synthesis of 4-alkynylpyrrolo[2,3-d]pyrimidines by palladium-catalyzed cross-coupling reactions

The palladium-catalyzed cross-coupling reaction of methyl 5-amino-4-chloro- and 5-amino-4-iodo-7-methyl-2-(methyl-sulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6- carboxylate with various terminal alkynes has been investigated. The 4-iodo derivative was found to be a good substrate for the synthesis of various 4-alkynylpyrrolopyrimidines. A simple synthesis of 4-(indol-2-yl)pyrrolo[2,3-d] pyrimidines by the reaction of 4-iodopyrrolopyrimidine with 2-ethynyl-N- mesylaniline in the presence dichlorobis(triphenylphosphine)palladium and copper(I) iodide is described. Georg Thieme Verlag Stuttgart.