100953-52-4

Basic information

• Product Name: N-(4-BroMo-phenyl)-benzene-1,2-diaMine
• Synonyms: N-(4-BroMo-phenyl)-benzene-1,2-diaMine;N1-(4-bromophenyl)-1,2-benzenediamine;N-(4-Bromophenyl)-1,2-benzenediamine
• CAS NO: 100953-52-4
• Molecular Formula: C₁₂H₁₁BrN₂
• Molecular Weight: 263.13314
• Mol File: 100953-52-4.mol
• Article Data: 28

Chemical Properties

• Melting Point: 128 °C
• Boiling Point: 373.3±27.0 °C(Predicted)
• Appearance: /
• Density: 1.512±0.06 g/cm3(Predicted)
• PKA: 4.90±0.10(Predicted)
• CAS DataBase Reference: N-(4-BroMo-phenyl)-benzene-1,2-diaMine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-BroMo-phenyl)-benzene-1,2-diaMine(100953-52-4)
• EPA Substance Registry System: N-(4-BroMo-phenyl)-benzene-1,2-diaMine(100953-52-4)

Safety Data

• Hazardous Substances Data: 100953-52-4(Hazardous Substances Data)

Usage

General Description

N-(4-Bromo-phenyl)-benzene-1,2-diamine is a chemical compound with the molecular formula C12H12BrN2. It is used in the production of various organic compounds and is widely used in the pharmaceutical and chemical industries as an intermediate for the synthesis of dyes, pigments, polymers, and pharmaceutical drugs. N-(4-BroMo-phenyl)-benzene-1,2-diaMine is a derivative of benzene and contains a bromine atom and two amine groups. It is both a solid and a liquid at different temperatures and is considered to be potentially hazardous if not handled properly. Additionally, it is important to follow proper safety precautions and regulations when handling and storing this chemical.

Upstream product

• 106-37-6 1.4-dibromobenzene 
• 88-74-4 2-nitro-aniline 
• 1493-27-2 ortho-nitrofluorobenzene 
• 106-40-1 4-bromo-aniline 
• 88-73-3 2-Chloronitrobenzene 
• 58476-59-8 4-bromo-N-(2-nitrophenyl)benzenamine 

Downstream Products

• 534-85-0 N-phenyl-1,2-benzenediamine 
• 760212-66-6 N-[2-(4-bromophenyl amino)-phenyl]-acetamide 
• 1169709-27-6 C₁₉H₁₄Br₂N₂O 
• 760212-58-6 4-(2-phenyl-1H-benzo[d]imidazol-1-yl)1-bromobenzene 
• 867044-33-5 (4-(2-phenyl-1H-benzo[d]imidazol-1-yl)phenyl)-boronic acid 
• 1353731-56-2 5-(4-bromophenyl)-3-isopropylimino-2-(3-pyridyl)amino-3,5-dihydrophenazine 
• 1353731-86-8 5-(4-bromophenyl)-3-(4-methoxycyclohexyl)imino-2-(6-methyl-3-pyridyl)amino-3,5-dihydrophenazine 
• 1353731-88-0 5-(4-bromophenyl)-3-(4-tetrahydropyranyl)imino-2-(6-methyl-3-pyridyl)amino-3,5-dihydrophenazine 
• 1353731-78-8 5-(4-bromophenyl)-3-isopropylimino-2-(6-methyl-3-pyridyl)amino-3,5-dihydrophenazine 
• 1353731-97-1 5-(4-bromophenyl)-3-(4-methoxycyclohexyl)imino-2-(2-methyl-3-pyridyl)amino-3,5-dihydrophenazine 

Relevant articles and documents

Efficient deep-blue emitters based on triphenylamine-linked benzimidazole derivatives for nondoped fluorescent organic light-emitting diodes

Two triphenylamine-substituted benzimidazole derivatives were synthesized for use as efficient deep-blue emitters in nondoped fluorescent organic light-emitting diodes (FLOLEDs). The molecular design of 40,40 0-(1H-benzo[d]imidazole-1,2-diyl)bis(N,N-diphenylbiphenyl-4-amine) (T2B) to limit the molecular packing density enabled T2B-based devices to suppress the exciton quenching by a bulky three-dimensional structure. Nondoped FLOLEDs fabricated using T2B as a blue emitter exhibited an external quantum efficiency of 4.67% with color coordinates of (0.15, 0.08).

Benzimidazolone derivatives organic light emitting compound and organic electroluminescent device including the same

Provided is a benzo imidazolone derivative organic electroluminescent compound represented by chemical formula a. Chemical Formula a. The benzo imidazolone derivative organic light emitting compound is suitable for inclusion in an organic electroluminescent device. Both electrochemical stability and thermal stability can be satisfactorily met.

A green and practical reduction of N-(4-chlorophenyl)-2-nitroaniline and its derivatives to corresponding N-substituted-benzene-1,2-diamines using thiourea dioxide

A new effective approach for synthesizing diverse N-substituted-benzene-1,2-diamines is reported. The treatment of N-substituted-2-nitroanilines with thiourea dioxide in the presence of sodium hydroxide efficiently formed the corresponding N-substituted-benzene-1,2-diamines, including N-(4-chlorophenyl)benzene-1,2-diamine with a good yield of 94%. The by-product is environmentally-friendly urea and is easy to separate from the product by filtration procedure that enhances the convenience of the approach.

Design, synthesis and biological evaluation of novel 4-phenoxypyridine based 3-oxo-3,4-dihydroquinoxaline-2-carboxamide derivatives as potential c-Met kinase inhibitors

Blocking c-Met kinase activity by small-molecule inhibitors has been identified as a promising approach for the treatment of cancers. Herein, we described the design, synthesis, and biological evaluation of a series of 4-phenoxypyridine-based 3-oxo-3,4-dihydroquinoxaline derivatives as c-Met kinase inhibitors. Inhibitory activitives against c-Met kinase evaluation indicated that most of compounds showed excellent c-Met kinase activity in vitro, and IC50 values of ten compounds (23a, 23e, 23f, 23l, 23r, 23s, 23v, 23w, 23x and 23y) were less than 10.00 nM. Notably, three of them (23v, 23w and 23y) showed remarkable potency with IC50 values of 2.31 nM, 1.91 nM and 2.44 nM, respectively, and thus they were more potent than positive control drug foretinib (c-Met, IC50 = 2.53 nM). Cytotoxic evaluation indicated the most promising compound 23w showed remarkable cytotoxicity against A549, H460 and HT-29 cell lines with IC50 values of 1.57 μM, 0.94 μM and 0.65 μM, respectively. Furthermore, the acridine orange/ethidium bromide (AO/EB) staining, cell apoptosis assays by flow cytometry, wound-healing assays and transwell migration assays on HT-29 and/or A549 cells of 23w were performed. Especially compound 23w, which displayed potent antitumor, apoptosis induction and antimetastatic activity, could be used as a promising lead for further development. Meanwhile, their preliminary structure-activity relationships (SARs) were also discussed.