101104-43-2

Basic information

• Product Name: N-(2-(cyclohex-1-en-1-yl)ethyl)benzamide
• Synonyms: N-(2-(cyclohex-1-en-1-yl)ethyl)benzamide
• CAS NO: 101104-43-2
• Molecular Weight: 229.322
• Mol File: 101104-43-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(2-(cyclohex-1-en-1-yl)ethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(cyclohex-1-en-1-yl)ethyl)benzamide(101104-43-2)
• EPA Substance Registry System: N-(2-(cyclohex-1-en-1-yl)ethyl)benzamide(101104-43-2)

Safety Data

• Hazardous Substances Data: 101104-43-2(Hazardous Substances Data)

Upstream product

• 6975-71-9 1-cyclohexenylacetonitrile 
• 108-94-1 cyclohexanone 
• 65-85-0 benzoic acid 
• 98-88-4 benzoyl chloride 
• 3399-73-3 2-(1-cyclohexenyl)ethylamine 

Downstream Products

• 1062258-64-3 C₁₅H₁₇NO 
• 1062258-60-9 C₁₅H₁₆ClN 
• 102661-23-4 1-phenyl-1,2,3,4,5,6,7,8-octahydro-isoquinoline 
• 100955-51-9 1-phenyl-3,4,5,6,7,8-hexahydro-isoquinoline 

Relevant articles and documents

Pd-Catalyzed Remote Site-Selective and Stereoselective C(Alkenyl)-H Alkenylation of Unactivated Cycloalkenes

A palladium-catalyzed alkenylation involving remote δ-position C(alkenyl)-H activation of cycloalkenes reacting with electron-deficient alkenes is described. This method features excellent site selectivity and stereoselectivity to efficiently afford only E-selective highly substituted 1,3-diene derivatives with extra-ligand-free and good functional group tolerance including estrone and free N-H tryptamine under weakly alkaline conditions. Mechanistic studies suggest that picolinamide as a bidentate directing group enables the formation of unique alkenyl palladacycle intermediates.

Aryl amide small-molecule inhibitors of microRNA miR-21 function

MicroRNAs (miRNAs) are single stranded RNA molecules of ～22 nucleotides that negatively regulate gene expression. MiRNAs are involved in fundamental cellular processes, such as development, differentiation, proliferation, and survival. MiRNA misregulation has been linked to various human diseases, most notably cancer. MicroRNA-21 (miR-21), a well-established oncomiR, is significantly overexpressed in many types of human cancers, thus rendering miR-21 a potential therapeutic target. Using a luciferase-based reporter assay under the control of miR-21 expression, a high-throughput screen of >300,000 compounds led to the discovery of a new aryl amide class of small-molecule miR-21 inhibitors. Structure-activity relationship (SAR) studies resulted in the development of four aryl amide derivatives as potent and selective miR-21 inhibitors. The intracellular levels of various miRNAs in HeLa cells were analyzed by qRT-PCR revealing specificity for miR-21 inhibition over other miRNAs. Additionally, preliminary mechanism of action studies propose a different mode of action compared to previously reported miR-21 inhibitors, thus affording a new chemical probe for future studies.

Synthesis of 3,4,5,6,7,8-hexahydro-1-substituted phenyl isoquinoline and 3,4,5,6,7,8-hexahydro-1-substituted benzyl isoquinoline

Isoquinoline derivatives are obtained from amides using AlCl3-KI in acetonitrile solvent. This cyclo dehydrating Lewis acid produced no side product and yield is above 95% isoquinoline derivative at room temperature.