Welcome to LookChem.com Sign In|Join Free

Cas Database

10112-15-9

10112-15-9

Identification

  • Product Name:Benzenamine,N-ethyl-2-nitro-

  • CAS Number: 10112-15-9

  • EINECS:233-305-4

  • Molecular Weight:166.18

  • Molecular Formula: C8H10N2O2

  • HS Code:2921420090

  • Mol File:10112-15-9.mol

Synonyms:Aniline,N-ethyl-o-nitro- (6CI,7CI,8CI);2-Nitro-N-ethylaniline;Ethyl(2-nitrophenyl)amine;N-Ethyl-2-nitroaniline;N-Ethyl-2-nitrobenzenamine;N-Ethyl-o-nitroaniline;o-(Ethylamino)nitrobenzene;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Pictogram(s):HarmfulXn

  • Hazard Codes:Xn

  • Signal Word:Warning

  • Hazard Statement:H302 Harmful if swallowedH312 Harmful in contact with skin H315 Causes skin irritation H319 Causes serious eye irritation H332 Harmful if inhaled H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:N-Ethyl-2-nitroaniline
  • Packaging:250mg
  • Price:$ 55
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:N-Ethyl-2-nitroaniline 98%
  • Packaging:1g
  • Price:$ 91
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:N-Ethyl-2-nitroaniline
  • Packaging:500mg
  • Price:$ 237
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Crysdot
  • Product Description:N-Ethyl-2-nitroaniline 95+%
  • Packaging:25g
  • Price:$ 612
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Crysdot
  • Product Description:N-Ethyl-2-nitroaniline 95+%
  • Packaging:10g
  • Price:$ 319
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:BLDpharm
  • Product Description:N-Ethyl-2-nitroaniline 97+%
  • Packaging:1g
  • Price:$ 71
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:BLDpharm
  • Product Description:N-Ethyl-2-nitroaniline 97+%
  • Packaging:250mg
  • Price:$ 29
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:BLDpharm
  • Product Description:N-Ethyl-2-nitroaniline 97+%
  • Packaging:5g
  • Price:$ 212
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Apolloscientific
  • Product Description:N-Ethyl-2-nitroaniline
  • Packaging:5g
  • Price:$ 318
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Apolloscientific
  • Product Description:N-Ethyl-2-nitroaniline
  • Packaging:1g
  • Price:$ 142
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 26 Articles be found

THE MECHANISM OF N-ALKYLATION OF WEAK N-H-ACIDS BY PHASE TRANSFER CATALYSIS

Dehmlow, Eckehard V.,Thieser, Rainer,Zahalka, Hayder Ali,Sasson, Yoel

, p. 297 - 300 (1985)

The alkylation of aromatic amines in the presence of inorganic bases is accelerated by a PT catalyst even if KHCO3 is the base.ArNR(1-) ions seem not to be involved.A novel type of mechanism for a PTC process is proposed.

Unusual reactivity of zinc borohydride - Reduction of amides to amines

Narasimhan,Madhavan,Balakumar,Swarnalakshmi

, p. 391 - 394 (1997)

Zinc borohydride reduces secondary amides to the corresponding N-ethyl amines in excellent yields. The reduction requires only stoichiometric quantities of hydride and does not require the addition of any Lewis acid. The amides are isolated by simple hydrolysis of the reaction mixture.

Synthesis of new 1,2,3-triazole linked benzimidazole molecules as anti-proliferative agents

Sahay, Ishani I.,Ghalsasi, Prasanna S.

, p. 825 - 834 (2017)

One pot click chemistry is used to link triazole and benzimidazole pharmacophore to get N-((1-((1H-benzo[d]imidazol-2-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)aniline and its derivatives. Flexible linkages in the form of –CH2–R or –O–R/–N–R were designed during synthesis. All the newly synthesized compounds were characterized by FT-IR and NMR spectroscopy as well as high-resolution mass spectrometry. Selected compounds were screened for in vitro anti-proliferative activity using National Cancer Institute (NCI)-60 human tumor cell line screening program. The most potent structure N-((1-((1H-benzo[d]imidazol-2-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-4-chloroaniline 7e showed 40% growth inhibition in renal cancer cell line (UO-31) at 10 μM concentration.

Synthesis and evaluation of some new (1,2,4) triazolo(4,3-a)quinoxalin- 4(5h)-one derivatives as AMPA receptor antagonists

Abul-Khair, Hamada,Elmeligie, Salwa,Bayoumi, Ashraf,Ghiaty, Adel,El-Morsy, Ahmed,Hassan, Memy H.

, p. 1202 - 1208 (2013)

This study involves the synthesis and anticonvulsant evaluation of 1-ethyl-3-hydrazinylquinoxaline-2-(1H)-one (8), its chemical confirmations 9 and 10 and certain (1,2,4) triazolo(4,3-a)quinoxalin-4(5H)-one compounds 11, 12, 13, 13a, 13b, 13c, 13d, 13e, 13f, 14, 15, 16. The structure of the synthesized compounds was confirmed chemically by elemental analyses and spectral data (IR, 1H NMR, 13C NMR, and Mass). Docking studies were preformed to all of the synthesized compounds to predict, in a qualitative way, the anticonvulsant activity of the proposed compounds. There is a promising correlation between the results of molecular modeling and the anticonvulsant activity of the synthesized compounds. The highest fitting value was noticed for compounds 9 and 10, which showed the highest anticonvulsant activity.

Synthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives

Kankate, Rani S.,Gide, Parag S.,Belsare, Deepak P.

, p. 1855 - 1863 (2014)

Benzimidazole and piperazines are the important pharmacophores in the structures of many antifungal compounds. Further, the phenylmethanone are also a unique class of compounds whose antifungal profile is not much exploited. So to exploit their antifungal potential we have selected these three combinations and framed the novel parent structure for our research work. In this study a novel series of benzimidazoles derivatives was synthesized by microwave irradiation and characterized by 1H NMR, 13C NMR, Infra Red (IR), and Mass Spectroscopy (MS), and by elemental analysis. The screening of compound for in vitro (turbidimetric method) antifungal activity against C.albicans revealed activity in many of the compounds as comparable to that of ketoconazole.

In vivo- and in silico-driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors

Abulkhair, Hamada S.,Elmeligie, Salwa,Ghiaty, Adel,El-Morsy, Ahmed,Bayoumi, Ashraf H.,Ahmed, Hany E. A.,El-Adl, Khaled,Zayed, Mohamed F.,Hassan, Memy H.,Akl, Eman N.,El-Zoghbi, Mona S.

, (2021)

The lack of effective therapies for epileptic patients and the potentially harmful consequences of untreated seizure incidents have made epileptic disorders in humans a major health concern. Therefore, new and more potent anticonvulsant drugs are continually sought after,?to combat epilepsy. On the basis of the pharmacophoric structural specifications of effective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists with an efficient anticonvulsant activity, the present work reports the design and synthesis of two novel sets of quinoxaline derivatives. The anticonvulsant activity of the synthesized compounds was evaluated in vivo according to the pentylenetetrazol-induced seizure protocol, and the results were compared with those of perampanel as a reference drug. Among the synthesized compounds, 24, 28, 32, and 33 showed promising activities with ED50 values of 37.50, 23.02, 29.16, and 23.86 mg/kg, respectively. Docking studies of these compounds suggested that AMPA binding could be the mechanism of action of these derivatives. Overall, the pharmacophore-based structural optimization, in vivo?and in silico docking, and druglikeness studies indicated that the designed compounds could serve as promising candidates for the development of effective anticonvulsant agents with good pharmacokinetic profiles.

Tetraphenylethylene-based blue light material containing benzimidazole unit as well as preparation method and application

-

Paragraph 0027; 0028; 0029; 0090; 0091; 0092, (2017/10/10)

The invention discloses a tetraphenylethylene-based blue light material containing a benzimidazole unit. The tetraphenylethylene-based blue light material is shown as a structural formula I or II, wherein R1 is H, tert-butyl, n-butyl or hydroxyl, and R2 is alkyl. A 2-nitro-N-tert-butylphenyl amine or 2-nitro-N-n-butylphenyl amine precursor and a 4-formyl tetraphenylethylene precursor is firstly prepared, and then cyclization reaction is carried out to prepare a compound shown as the formula I or II. A preparation method of the compound is easy to operate, the reaction is moderate and the yield is high; the compound has relatively high decomposition temperature and glass-transition temperature, and shows blue fluorescence; the compound has a relatively good single-color property, so that an OLED (Organic Light Emitting Diode) device prepared by taking the compound as a luminescent material emits blue light; the starting voltage is 3.3V and the maximum brightness efficiency is 1.48cd/A. (The formula I and the formula II are shown in the description).

The thermal instability of 2,4 and 2,6-N-alkylamino-disubstituted and 2-N-alkylamino-substituted nitrobenzenes in weakly alkaline solution: Sec-amino effect

Walczak, Christopher,Payne, Thomas J.,Wade, Colin B.,Yonkey, Matthew,Scheid, Melissa,Badour, Alec,Mohanty, Dilip K.

, p. 681 - 687 (2015/05/13)

We report herein the preparation of two families of secondary amines by the reactions of two equivalents of monoamines with either 2,4 or 2,6-difluoronitrobenzenes in N,N-dimethylacetamide in the presence of anhydrous potassium carbonate, as precursors of biologically important nitric oxide donating N-nitrosamines. In both instances, these compounds could be prepared in quantitative yield when the reaction temperature was held below 130°C. Above this reaction temperature, an unexpected cyclization reaction between the nitro and newly formed adjacent secondary amine group leads to the formation of benzimidazole or quinoxaline rings in low yields. Reasonable reaction mechanisms for the cyclization reaction are proposed.

Imidoyl dichlorides as new reagents for the rapid formation of 2-aminobenzimidazoles and related azoles

Pollock, Julie A.,Kim, Sung Hoon,Katzenellenbogen, John A.

, p. 6097 - 6099 (2015/10/28)

The development of a reagent for the efficient synthesis of five- and six-membered azoles at room temperature is proposed. A variety of substituted 2-aminobenzimidazoles are synthesized in good to excellent yields. The ability to incorporate various protecting groups makes the imidoyl dichloride reagent amenable to a large number of syntheses. The reagent is applied to the total synthesis of the 2-aminobenzimidazole containing carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), from 2-chloro-3-nitropyridine in >60% yield in 6 steps.

Process route upstream and downstream products

Process route

ortho-nitrofluorobenzene
1493-27-2,127723-77-7

ortho-nitrofluorobenzene

6-(N-ethylamino)-3-methyluracil
58669-01-5

6-(N-ethylamino)-3-methyluracil

N-Ethyl-2-nitroaniline
10112-15-9

N-Ethyl-2-nitroaniline

6-Ethylamino-3-methyl-5-(2-nitrophenyl)uracil
108005-12-5

6-Ethylamino-3-methyl-5-(2-nitrophenyl)uracil

N,N-dimethyl-2-nitro-benzenamine
610-17-3

N,N-dimethyl-2-nitro-benzenamine

Conditions
Conditions Yield
With potassium carbonate; In N,N-dimethyl-formamide; at 160 ℃; for 40h;
0.6%
2.1%
59%
1-methyl-pyrrolidin-2-one
872-50-4,26138-58-9

1-methyl-pyrrolidin-2-one

ortho-nitrofluorobenzene
1493-27-2,127723-77-7

ortho-nitrofluorobenzene

6-(N-ethylamino)-3-methyluracil
58669-01-5

6-(N-ethylamino)-3-methyluracil

2-nitro-N-methylaniline
612-28-2

2-nitro-N-methylaniline

N-Ethyl-2-nitroaniline
10112-15-9

N-Ethyl-2-nitroaniline

3-methyl-10-ethylisoalloxazine
58668-94-3

3-methyl-10-ethylisoalloxazine

Conditions
Conditions Yield
at 160 ℃; for 30h;
3.5%
16%
9.8%
ortho-nitrofluorobenzene
1493-27-2,127723-77-7

ortho-nitrofluorobenzene

6-(N-ethylamino)-3-methyluracil
58669-01-5

6-(N-ethylamino)-3-methyluracil

2-nitro-N-methylaniline
612-28-2

2-nitro-N-methylaniline

N-Ethyl-2-nitroaniline
10112-15-9

N-Ethyl-2-nitroaniline

3-methyl-10-ethylisoalloxazine
58668-94-3

3-methyl-10-ethylisoalloxazine

Conditions
Conditions Yield
In sulfolane; at 160 ℃; for 72h; Product distribution; other solvents (DMF, HMPA, N-methylpyrrolidone), other time, K2CO3 as reagent;
29%
0.5%
0.9%
N-ethyl-N-phenylamine
103-69-5

N-ethyl-N-phenylamine

N-Ethyl-4-nitroanilin
3665-80-3

N-Ethyl-4-nitroanilin

N-Ethyl-2-nitroaniline
10112-15-9

N-Ethyl-2-nitroaniline

Conditions
Conditions Yield
With bromine; silver nitrate; triphenylphosphine; In acetonitrile; at 20 ℃; for 0.0833333h;
66%
27%
ortho-nitrofluorobenzene
1493-27-2,127723-77-7

ortho-nitrofluorobenzene

N-Ethyl-2-nitroaniline
10112-15-9

N-Ethyl-2-nitroaniline

Conditions
Conditions Yield
at 20 ℃;
95%
With potassium carbonate; In N,N-dimethyl acetamide; water; toluene; for 2.5h; Dean-Stark; Inert atmosphere; Reflux;
73%
In N,N-dimethyl-formamide;
72%
In dimethyl sulfoxide; at 100 ℃; for 10h;
With sodium acetate; at 80 ℃;
In tetrahydrofuran; at 20 ℃; Sealed tube;
With potassium carbonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 20 ℃; for 3.5h;
In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;
In N,N-dimethyl-formamide; at 20 ℃;
In methanol; at 55 ℃; for 15h;
With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 60 ℃; for 18h;
With 2-(1-chloroethyl)-1H-benzo[d]imidazole; In N,N-dimethyl-formamide; for 0.166667h; Microwave irradiation; Cooling;
o-nitroacetanilide
552-32-9

o-nitroacetanilide

N-Ethyl-2-nitroaniline
10112-15-9

N-Ethyl-2-nitroaniline

Conditions
Conditions Yield
With zirconium(IV) borohydride; In tetrahydrofuran; at 25 ℃; for 2h;
90%
With zinc(II) tetrahydroborate; In tetrahydrofuran; for 8h; Heating;
30%
ethyl bromide
74-96-4

ethyl bromide

2-nitro-aniline
88-74-4

2-nitro-aniline

N-Ethyl-2-nitroaniline
10112-15-9

N-Ethyl-2-nitroaniline

Conditions
Conditions Yield
With sodium hydride; In N,N-dimethyl-formamide; at 25 - 30 ℃; for 0.25h;
90%
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; at 40 ℃; for 2h;
42 % Chromat.
2-Chloronitrobenzene
88-73-3

2-Chloronitrobenzene

N-Ethyl-2-nitroaniline
10112-15-9

N-Ethyl-2-nitroaniline

Conditions
Conditions Yield
In water; at 105 ℃; for 24h; Sealed vessel;
99%
In dimethyl sulfoxide;
85%
With ethanol; at 170 ℃;
acetaldehyde
75-07-0,9002-91-9

acetaldehyde

2-nitro-aniline
88-74-4

2-nitro-aniline

N-Ethyl-2-nitroaniline
10112-15-9

N-Ethyl-2-nitroaniline

Conditions
Conditions Yield
With sodium tetrahydroborate; sulfuric acid; In tetrahydrofuran; 1.) 0 deg C, 2.) room temperature, 40 min;
77%
Triethylindium
923-34-2

Triethylindium

2-nitrobenzenediazonium o-benzenedisulfonimide

2-nitrobenzenediazonium o-benzenedisulfonimide

o-benzenedisulfonimide
4482-01-3

o-benzenedisulfonimide

N-Ethyl-2-nitroaniline
10112-15-9

N-Ethyl-2-nitroaniline

Conditions
Conditions Yield
In tetrahydrofuran; at 20 - 25 ℃;
69%

Global suppliers and manufacturers

Global( 20) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Kono Chem Co.,Ltd
  • Business Type:Other
  • Contact Tel:86-29-86107037-8015
  • Emails:info@konochemical.com
  • Main Products:82
  • Country:China (Mainland)
  • Finetech Industry Limited
  • Business Type:Trading Company
  • Contact Tel:86-27-87465837
  • Emails:sales@finetechnology-ind.com
  • Main Products:29
  • Country:China (Mainland)
  • BOC Sciences
  • Business Type:Trading Company
  • Contact Tel:1-631-485-4226
  • Emails:sales@bocsci.com
  • Main Products:41
  • Country:United States
  • Antimex Chemical Limied
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-21-50563169
  • Emails:anthony@antimex.com
  • Main Products:163
  • Country:China (Mainland)
  • Debye Scientific
  • Business Type:Lab/Research institutions
  • Contact Tel:+85221376140
  • Emails:sales@debyesci.com
  • Main Products:13
  • Country:China (Mainland)
  • CHEMOS GmbH
  • Business Type:Trading Company
  • Contact Tel:+49 9402 9336 0
  • Emails:sales@chemos-group.com
  • Main Products:1
  • Country:Germany
  • Alfa Aesar
  • Business Type:Trading Company
  • Contact Tel:9785216300
  • Emails:info@alfa.com
  • Main Products:1
  • Country:United States
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 10112-15-9
Post Buying Request Now
close
Remarks: The blank with*must be completed