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101187-40-0

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  • Factory Price OLED 99% 101187-40-0 5,8,11-Trioxa-2-azatridecanoic acid, 13-amino-,1,1-dimethylethyl ester Manufacturer

    Cas No: 101187-40-0

  • USD $ 0.1-0.1 / Gram

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  • Featured products 5,8,11-Trioxa-2-azatridecanoic acid, 13-amino-, 1,1-dimethylethyl ester)

    Cas No: 101187-40-0

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101187-40-0 Usage

Uses

N-Boc-1,11-Diamino-3,6,9-trioxaundecane is a useful research chemical.

Description

t-Boc-N-Amido-PEG3-amine is a PEG linker with an amino group and Boc-protected amino. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to free the amine.

Chemical Properties

Colorless viscous liquid

Check Digit Verification of cas no

The CAS Registry Mumber 101187-40-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,1,8 and 7 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 101187-40:
(8*1)+(7*0)+(6*1)+(5*1)+(4*8)+(3*7)+(2*4)+(1*0)=80
80 % 10 = 0
So 101187-40-0 is a valid CAS Registry Number.

101187-40-0 Well-known Company Product Price

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  • (07185)  N-Boc-1,11-diamino-3,6,9-trioxaundecaneoxalatesalt  purum, ≥97.0% (TLC)

  • 101187-40-0

  • 07185-100MG

  • 1,895.40CNY

  • Detail

101187-40-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]carbamate

1.2 Other means of identification

Product number -
Other names t-Boc-N-Amido-PEG3-Amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:101187-40-0 SDS

101187-40-0Relevant articles and documents

Synthesis and photochemical protein crosslinking studies of hydrophilic naphthalimides

Zhang, Jianxing,Woods, R. Jeremy,Brown, Philip B.,Kap, Duk Lee,Kane, Robert R.

, p. 853 - 856 (2002)

A mixture of 4-alkylamino-1,8-naphthalimides has previously been reported to exhibit potential utility as a photochemical tissue-bonding reagent. In order to determine which constituents of the mixture were responsible for the observed tissue bonding and

Solution- and solid-phase synthesis of components for tethered bilayer membranes

Bendavid,Burns,Field,Hashimoto,Ridley,Sandanayake,Wieczorek

, p. 3709 - 3716 (2001)

The synthesis of the novel compound PhCH2SS(C24H44N4O10) (C20H41) (5) for the preparation of tethered bilayer membranes is described. The compound is the all-amide analogue of the previously reported ester-containing membrane-forming material PhCH2SS(C24H40O14) (C20H41) (1). The advanced intermediate (C20S41) C16H28N3O8 (17) was prepared from the same starting materials using both solution-phase (13% yield) and solid-phase (81% yield) techniques. Monolayers on gold derived from 5 have been analyzed by ellipsometry and FTIR. The monolayers exhibit thicknesses similar to monolayers derived from 1 and possess H-bonded amide functionality.

GM1-Binding Conjugates to Improve Intestinal Permeability

Melkoumov, Alexandre,St-Jean, Isabelle,Banquy, Xavier,Leclair, Grégoire,Leblond Chain, Jeanne

, p. 60 - 70 (2019)

Drugs and proteins with poor intestinal permeability have a limited oral bioavailability. To remediate this problem, a receptor-mediated endocytosis and transcytosis approach was explored. Indeed, the nontoxic β subunit of cholera toxin (CTB) can cross the intestinal barrier by binding to receptor GM1. In this study, we explored the use of GM1-binding peptides and CTB as potential covalent carriers of poorly permeable molecules. GM1-binding peptides (G23, P3) and CTB were conjugated to poorly permeable fluorescent probes such as fluorescein isothiocyanate (FITC) and albumin-FITC using triethylene glycol spacers and click chemistry. The affinity of the peptide conjugates with receptor GM1 was confirmed by isothermal titration calorimetry or microscale thermophoresis, and the results suggested the involvement of nonspecific interactions. Conjugating the model drugs to G23 and P3 improved the internalization into Caco-2 and T84 cells, although the process was not dependent on the amount of GM1 receptor. However, conjugation of bovine serum albumin FITC to CTB increased the internalization in the same cells in a GM1-dependent pathway. Peptide conjugates demonstrated a limited permeability through a Caco-2 monolayer, whereas G23 and CTB conjugates slightly enhanced permeability through a T84 cell monolayer compared to model drugs alone. Since CTB can improve the permeability of large macromolecules such as albumin, it is an interesting carrier for the improvement of oral bioavailability of various other macromolecules such as heparins, proteins, and siRNAs.

FUSED HETEROCYCLIC BENZODIAZEPINE DERIVATIVES AND USES THEREOF

-

Page/Page column 126-127; 129, (2020/05/29)

The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.

Bioorthogonal Ligation and Cleavage by Reactions of Chloroquinoxalines with ortho-Dithiophenols

Fu, Hua,Li, Hongyun,Li, Youshan,Lou, Zhenbang,Yang, Haijun,Zhao, Yufen

, p. 3671 - 3677 (2020/02/04)

A bioorthogonal ligation and cleavage method via reactions of chloroquinoxalines (CQ) and ortho-dithiophenols (DT) is presented. Double nucleophilic substitutions of ortho-dithiophenols to chloroquinoxalines provide conjugates containing tetracyclic benzo[5,6][1,4]dithiino[2,3-b]quinoxaline with strong built-in fluorescence together with release of the other functional molecules. Three cleavable linkers were designed and successfully used in release of the molecules containing biotin from the protein conjugates. The CQ-DT bioorthogonal reactions can be applied for the bioorthogonal ligations, bioorthogonal cleavages, and trans-tagging of proteins, and show advantages of readily accessible unnatural orthogonal groups, appealing reaction kinetics (k2≈1.3 m?1 s?1), excellent biocompatibility of orthogonal groups, and high stability of conjugates. This complements previous bioorthogonal reactions and is a new route for protein-fishing applications and in-gel fluorescence analysis.

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