1013027-15-0Relevant articles and documents
Synthesis and evaluation of multi-functional NO-donor/insulin-secretagogue derivatives for the treatment of type II diabetes and its cardiovascular complications
Digiacomo, Maria,Martelli, Alma,Testai, Lara,Lapucci, Annalina,Breschi, Maria C.,Calderone, Vincenzo,Rapposelli, Simona
, p. 422 - 428 (2015)
Although there is a significant effort in the discovery of effective therapies to contrast both the pathological endocrine and metabolic aspects of diabetes and the endothelial dysfunction associated with this disease, no hypoglycemic drug has been proven
Evaluation of the NO-releasing properties of NO-donor linkers
Calderone, Vincenzo,Digiacomo, Maria,Martelli, Alma,Minutolo, Filippo,Rapposelli, Simona,Testai, Lara,Balsamo, Aldo
, p. 189 - 195 (2008/09/20)
This work describes the synthesis of some benzoic (1-4) and alcoholic (5-7) nitrooxy derivatives, which are nitric oxide (NO) donors in themselves, and can also be seen as useful linkers that can be used in multi-target drugs capable of releasing NO. The