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4-EPICHLORTETRACYCLINE HYDROCHLORIDE is a Tetracycline derivative that is formed as a degradation product of chlorotetracycline through acid-catalysed isomerisation of the dimethylamino group at C4. It is characterized by its pale yellow to orange powder appearance and has little antibiotic activity. However, its presence is indicative of poor storage and handling of chlortetracycline.

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  • 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride, (4R,4aS,5aS,6S,12aS)- (9CI)

    Cas No: 101342-45-4

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  • (4R,6S)-7-chloro-4-(dimethylamino)-1,6,10,12,12a-pentahydroxy-6-methyl-3,11-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide hydrochloride

    Cas No: 101342-45-4

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  • 101342-45-4 Structure
  • Basic information

    1. Product Name: 4-EPICHLORTETRACYCLINE HYDROCHLORIDE
    2. Synonyms: 4-EPICHLORTETRACYCLINE HYDROCHLORIDE;(4R,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Monohydrate;4-Epichlortetracycline Hydrochlorid;4-Epichlortetracycline hydrochloride, 97%, can be used as secondary standard;4-Epichlortetracycline hydrochlorideECTC;4-Epichlortetracycline hydrochloride, can be used as secondary standard, 97% 100MG;4-Epichlortetracycline hydrochloride, can be used as secondary standard, 97% 500MG;Epichlortetracycline hydrochloride
    3. CAS NO:101342-45-4
    4. Molecular Formula: C22H23ClN2O8.ClH
    5. Molecular Weight: 515.344
    6. EINECS: N/A
    7. Product Categories: All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 101342-45-4.mol
  • Chemical Properties

    1. Melting Point: >250°C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: Pale yellow to orange/Powder
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
    8. Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
    9. Stability: Hygroscopic, Unstable in Solution
    10. CAS DataBase Reference: 4-EPICHLORTETRACYCLINE HYDROCHLORIDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-EPICHLORTETRACYCLINE HYDROCHLORIDE(101342-45-4)
    12. EPA Substance Registry System: 4-EPICHLORTETRACYCLINE HYDROCHLORIDE(101342-45-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 101342-45-4(Hazardous Substances Data)

101342-45-4 Usage

Uses

Used in Pharmaceutical Industry:
4-EPICHLORTETRACYCLINE HYDROCHLORIDE is used as a metalloprotease inhibitor for treating tissue destructive diseases and cancer. Its application in this industry is due to its ability to inhibit the activity of metalloproteases, enzymes that play a crucial role in the degradation of tissues and the progression of certain diseases.
Used in Quality Control of Chlortetracycline Storage and Handling:
Although 4-EPICHLORTETRACYCLINE HYDROCHLORIDE has little antibiotic activity, its abundance can serve as an indicator of poor storage and handling practices for chlortetracycline. This makes it useful in ensuring the quality and efficacy of chlortetracycline products by monitoring the presence of this degradation product.

Check Digit Verification of cas no

The CAS Registry Mumber 101342-45-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,3,4 and 2 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 101342-45:
(8*1)+(7*0)+(6*1)+(5*3)+(4*4)+(3*2)+(2*4)+(1*5)=64
64 % 10 = 4
So 101342-45-4 is a valid CAS Registry Number.

101342-45-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-EPICHLORTETRACYCLINE HYDROCHLORIDE

1.2 Other means of identification

Product number -
Other names Chlortetracyclin-hydrochlorid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:101342-45-4 SDS

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