Welcome to LookChem.com Sign In|Join Free

Cas Database

101421-15-2

101421-15-2

Identification

  • Product Name:Benzonitrile, 2-iodo-5-nitro-

  • CAS Number: 101421-15-2

  • EINECS:

  • Molecular Weight:274.018

  • Molecular Formula: C7H3IN2O2

  • HS Code:

  • Mol File:101421-15-2.mol

Synonyms:2-Jod-5-nitro-benzonitril;1-CYANO-2-IODO-5-NITROBENZENE;2-iodo-5-nitro-benzonitrile;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Ambeed
  • Product Description:2-Iodo-5-nitrobenzonitrile 97%
  • Packaging:5g
  • Price:$ 120
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Ambeed
  • Product Description:2-Iodo-5-nitrobenzonitrile 97%
  • Packaging:1g
  • Price:$ 35
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Ambeed
  • Product Description:2-Iodo-5-nitrobenzonitrile 97%
  • Packaging:25g
  • Price:$ 370
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Alichem
  • Product Description:2-Iodo-5-nitrobenzonitrile
  • Packaging:1g
  • Price:$ 1549.6
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Alichem
  • Product Description:2-Iodo-5-nitrobenzonitrile
  • Packaging:500mg
  • Price:$ 863.9
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Alichem
  • Product Description:2-Iodo-5-nitrobenzonitrile
  • Packaging:250mg
  • Price:$ 470.4
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:AHH
  • Product Description:2-iodo-5-nitrobenzonitrile 97%
  • Packaging:5g
  • Price:$ 213
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 5 Articles be found

Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide

Mukhopadhyay, Sushobhan,Batra, Sanjay

supporting information, p. 14622 - 14626 (2018/09/21)

A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimide (NXS) in DMF at room temperature under metal- and acid-free condition is described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide.

Synthesis and properties of microenvironment-sensitive oligonucleotides containing a small fluorophore, 3-aminobenzonitrile or 3-aminobenzoic acid

Ozaki, Hiroaki,Kawai, Takeshi,Kuwahara, Masayasu

, p. 7177 - 7184 (2017/11/16)

Two C-nucleosides bearing small fluorescent groups as a base were synthesized by Heck-type coupling reaction and incorporated into DNA. They exhibited environment-sensitive fluorescence and opposite solvatochromic properties. The modified DNAs containing 3-aminobenzonitrile or 3-aminobenzoic acid retained the duplexes and their fluorescence reflected the microenvironment.

Palladium-catalyzed highly selective ortho-halogenation (I, Br, Cl) of arylnitriles via sp2 C-H bond activation using cyano as directing group

Du, Bingnan,Jiang, Xiaoqing,Sun, Peipei

, p. 2786 - 2791 (2013/04/24)

A palladium-catalyzed ortho-halogenation (I, Br, Cl) of arylnitrile is described. The optimal reaction conditions were identified after examining various factors such as catalyst, additive, solvent, and reaction temperature. Using cyano as the directing group, the halogenation reaction gave good to excellent yields. The method is compatible to the arylnitriles with either electron-withdrawing or electron-donating groups. The reaction is available to the substrate in at least gram scale. The present method was successfully applied to the synthesis of the precursors of paucifloral F and isopaucifloral F.

Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors

Sato, Motohide,Kawakami, Hiroshi,Motomura, Takahisa,Aramaki, Hisateru,Matsuda, Takashi,Yamashita, Masaki,Ito, Yoshiharu,Matsuzaki, Yuji,Yamataka, Kazunobu,Ikeda, Satoru,Shinkai, Hisashi

supporting information; experimental part, p. 4869 - 4882 (2010/03/02)

Human immunodeficiency virus type 1 (HIV-1) integrase is a crucial target for antiretroviral drugs, and several keto - enol acid class (often referred to as diketo acid class) inhibitors have clinically exhibited-marked antiretroviral activity. Here, we show the synthesis and the detailed structure - activity relationship of the quinolone carboxylic acids as a novel monoketo acid class of integrase inhibitors. 6-(3-Chloro-2-fluorobenzyl)-1-((2S)-1-hydroxy-3,3- dimethylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 51, which showed an IC50 of 5.8 nMin the strand transfer assay and an ED50 of 0.6 nMin the antiviral assay, and 6-(3-chloro-2-fluorobenzyl) -1-((2S)-1-hydroxy-3-methylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3- carboxylic acid 49, which had an IC50 of 7.2 nMand an ED50 of 0.9 nM, were the most potent compounds in this class. The monoketo acid 49 was much more potent at inhibiting integrasecatalyzed strand transfer processes than 3′-processing reactions, as is the case with the keto - enol acids. Elvitegravir 49 was chosen as a candidate for further studies and is currently in phase 3 clinical trials.

Carbopalladation of nitriles: Synthesis of 2,3-diarylindenones and polycyclic aromatic ketones by the Pd-catalyzed annulation of alkynes and bicyclic alkenes by 2-iodoarenenitriles

Pletnev, Alexandre A.,Tian, Qingping,Larock, Richard C.

, p. 9276 - 9287 (2007/10/03)

2-Iodobenzonitrile, its derivatives, and various heterocyclic analogues undergo palladium(O)-catalyzed annulation onto diarylacetylenes or bicyclic alkenes to afford 2,3-diarylindenones and polycyclic aromatic ketones in very good to excellent yields. This reaction represents one of the first examples of the addition of an organopalladium moiety to the carbon-nitrogen triple bond of a nitrile. The reaction is compatible with a number of functional groups. A reaction mechanism, as well as a model accounting for the electronic effects of substituents on the aromatic ring of the nitrile, is proposed.

Process route upstream and downstream products

Process route

5-nitroanthranilonitrile
17420-30-3

5-nitroanthranilonitrile

2-iodo-5-nitrobenzonitrile
101421-15-2

2-iodo-5-nitrobenzonitrile

Conditions
Conditions Yield
With N-iodo-succinimide; sodium nitrite; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
84%
5-nitroanthranilonitrile; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h; Inert atmosphere;
With potassium iodide; In water; at 0 - 20 ℃; Inert atmosphere;
73.9%
5-nitroanthranilonitrile; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;
With potassium iodide; In water; at 0 - 20 ℃; Further stages.;
65%
5-nitroanthranilonitrile; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;
With sodium iodide; In water; at 0 - 20 ℃;
3-nitrobenzonitrile
619-24-9

3-nitrobenzonitrile

2-iodo-5-nitrobenzonitrile
101421-15-2

2-iodo-5-nitrobenzonitrile

Conditions
Conditions Yield
With N-iodo-succinimide; palladium diacetate; toluene-4-sulfonic acid; In 1,2-dichloro-ethane; at 70 ℃; for 12h; Sealed tube;
79%
5-nitroanthranilonitrile
17420-30-3

5-nitroanthranilonitrile

2-iodo-5-nitrobenzonitrile
101421-15-2

2-iodo-5-nitrobenzonitrile

Conditions
Conditions Yield
With N-iodo-succinimide; sodium nitrite; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
84%
5-nitroanthranilonitrile; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h; Inert atmosphere;
With potassium iodide; In water; at 0 - 20 ℃; Inert atmosphere;
73.9%
5-nitroanthranilonitrile; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;
With potassium iodide; In water; at 0 - 20 ℃; Further stages.;
65%
5-nitroanthranilonitrile; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;
With sodium iodide; In water; at 0 - 20 ℃;
3-nitrobenzonitrile
619-24-9

3-nitrobenzonitrile

2-iodo-5-nitrobenzonitrile
101421-15-2

2-iodo-5-nitrobenzonitrile

Conditions
Conditions Yield
With N-iodo-succinimide; palladium diacetate; toluene-4-sulfonic acid; In 1,2-dichloro-ethane; at 70 ℃; for 12h; Sealed tube;
79%

Global suppliers and manufacturers

Global( 1) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
close

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields

CAS No.:
* Product Name:
* Your email:

Your email will be used to sign-in to LookChem.com
* Requirements:
* Valid for:
 
Post Buying Request Now
close
Remarks: The blank with*must be completed