101747-17-5

Basic information

• Product Name: 1-(tert-butyl)-4-(phenoxymethyl)benzene
• Synonyms: 1-(tert-butyl)-4-(phenoxymethyl)benzene
• CAS NO: 101747-17-5
• Molecular Weight: 240.345
• Mol File: 101747-17-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-(tert-butyl)-4-(phenoxymethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(tert-butyl)-4-(phenoxymethyl)benzene(101747-17-5)
• EPA Substance Registry System: 1-(tert-butyl)-4-(phenoxymethyl)benzene(101747-17-5)

Safety Data

• Hazardous Substances Data: 101747-17-5(Hazardous Substances Data)

Upstream product

• 18880-00-7 1-(bromomethyl)-4-(1,1-dimethylethyl)benzene 
• 108-95-2 phenol 
• 31575-75-4 2-bromophenyl benzyl ether 
• 19692-45-6 4-tert-butylbenzyl chloride 
• 98-80-6 phenylboronic acid 

Downstream Products

• 98-51-1 4-tert-butyltoluene 
• 108-95-2 phenol 
• 1042518-89-7 4-(4-tert-butylbenzyloxy)benzonitrile 
• 56502-40-0 2-(4-(tert-butyl)benzyl)phenol 
• 6425-41-8 N-cyclohexylmorpholine 

Relevant articles and documents

An alternative route for boron phenoxide preparation from arylboronic acid and its application for C[sbnd]O bond formation

An efficient synthetic route to benzyl phenyl ether preparation has been successfully developed via a one-pot synthetic protocol utilizing a combination of arylboronic acids, hydrogen peroxide (H2O2), and benzyl halides. The whole procedure consists of two consecutive reactions, formation of boron phenoxide from arylboronic acids and its nucleophilic attack. A simple operation under mild conditions such as room-temperature ionic liquid (choline hydroxide), aerobic environment, and absence of metal- and base-catalysts has been employed. Expansion to utilize benzyl surrogates was also successfully accomplished.

A General Catalytic Method for Highly Cost- and Atom-Efficient Nucleophilic Substitutions

A general formamide-catalyzed protocol for the efficient transformation of alcohols into alkyl chlorides, which is promoted by substoichiometric amounts (down to 34 mol %) of inexpensive trichlorotriazine (TCT), is introduced. This is the first example of a TCT-mediated dihydroxychlorination of an OH-containing substrate (e.g., alcohols and carboxylic acids) in which all three chlorine atoms of TCT are transferred to the starting material. The consequently enhanced atom economy facilitates a significantly improved waste balance (E-factors down to 4), cost efficiency, and scalability (>50 g). Furthermore, the current procedure is distinguished by high levels of functional-group compatibility and stereoselectivity, as only weakly acidic cyanuric acid is released as exclusive byproduct. Finally, a one-pot protocol for the preparation of amines, azides, ethers, and sulfides enabled the synthesis of the drug rivastigmine with twofold SN2 inversion, which demonstrates the high practical value of the presented method.

METHOD OF CONVERTING ALCOHOL TO HALIDE

The present invention relates to a method of converting an alcohol into a corresponding halide. This method comprises reacting the alcohol with an optionally substituted aromatic carboxylic acid halide in presence of an N-substituted formamide to replace a hydroxyl group of the alcohol by a halogen atom. The present invention also relates to a method of converting an alcohol into a corresponding substitution product. The second method comprises: (a) performing the method of the invention of converting an alcohol into the corresponding halide; and (b) reacting the corresponding halide with a nucleophile to convert the halide into the nucleophilic substitution product.