10186-66-0Relevant articles and documents
Preparation method of 2-fluoro-2-alkyloxy trifluoropropionate
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Paragraph 0024; 0025; 0026; 0027; 0028; 0029; 0034; 0035, (2017/08/29)
The invention discloses a preparation method of 2-fluoro-2-alkyloxy trifluoropropionate. In the presence of an organic alkali and/or an inorganic alkali, hexafluoropropylene oxide and alkyl alcohols carry out reactions to obtain corresponding 2-fluoro-2-alkyloxy trifluoropropionate. The provided method has the advantages of suitable reaction temperature, high reaction yield, good selectivity, little amount of waste solid, waste water, and waste gas, and easiness for industrialization. The prepared 2-fluoro-2-alkyloxy trifluoropropionate can be used as a trifluoromethylation reagent for the synthesis of novel medicines and pesticides.
Formylimine versus Isocyanate - an Unusual Tautomerism of a Trifluoroalanine Derivative
Matthies, Dieter,Siewers, Stefan
, p. 159 - 162 (2007/10/02)
The intermediate 7a formed by hydrogen chloride elimination of 6 can easily tautomerize to the isolable isocyanate 7b.Depending on the reaction conditions nucleophiles react with 7a and 7b to give the corresponding products 8 or 9, respectively. Key Words