102014-92-6

Basic information

• Product Name: 1-methylpropyl pyridine-3-carboxylate
• Synonyms: 3-pyridinecarboxylic acid, 1-methylpropyl ester; sec-Butyl nicotinate
• CAS NO: 102014-92-6
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.2157
• Mol File: 102014-92-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 245.9°C at 760 mmHg
• Flash Point: 102.5°C
• Density: 1.051g/cm³
• Vapor Pressure: 0.0279mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: 1-methylpropyl pyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methylpropyl pyridine-3-carboxylate(102014-92-6)
• EPA Substance Registry System: 1-methylpropyl pyridine-3-carboxylate(102014-92-6)

Safety Data

• Hazardous Substances Data: 102014-92-6(Hazardous Substances Data)

Upstream product

• 59-67-6 nicotinic acid 
• 100-26-5 Pyridine-2,5-dicarboxylic acid 
• 78-92-2 iso-butanol 
• 10400-19-8 3-pyridinecarbonyl chloride 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 103797-24-6 (+/-)-pyridine-2,3-dicarboxylic acid-3-sec-butyl ester 
• 103796-27-6 (+/-)-pyridine-2,3-dicarboxylic acid-2-sec-butyl ester 
• 103796-27-6 pyridine-2,3-dicarboxylic acid-2-((S)-sec-butyl ester) 
• 103797-24-6 pyridine-2,3-dicarboxylic acid-3-((R)-sec-butyl ester) 

Relevant articles and documents

Derivatization of secondary aliphatic alcohols to picolinates - A new option for HPLC analysis with chiral stationary phase

Derivatization of secondary alcohols (R1R2CHOH) to benzoates has frequently employed to determine enantiomer ratios using HPLC with chiral stationary phase (CSP). However, a small difference in substituents (R1, R2) often results in insufficient separation. To find an alternative derivatization that detects such a small difference, picolinates (2-pyridyl-CO2CHR1R2) possessing Me/Et, Me/vinyl, Me/acetylenic, Et/n-Pr, and n-Pr/allyl substituents were prepared and separation efficiency was compared with that of benzoates (PhCO2CHR1R2). Eight commercially available CSPs containing carbamates or benzoates of cellulose and amylose were examined to find that retention factors (k'1 and k'2) and resolution (Rs) of picolinates were greater than those of the corresponding benzoates and that good to excellent Rs values (≥1.25) were recorded over a wide range of CSPs.