10203-58-4

Basic information

• Product Name: Diethyl isobutylmalonate
• Synonyms: ISOBUTYLMALONIC ACID DIETHYL ESTER;DIETHYL ISOBUTYLMALONATE;DIETHYL (2-METHYLPROPYL)MALONATE;(2-methylpropyl)-propanedioicacidiethylester;Diethyl 2-isobutylmalonate;Ethyl 2-carbethoxy-4-methyl pentanoate;Ethyl isobutyl malonate;Malonic acid, isobutyl-, diethyl ester
• CAS NO: 10203-58-4
• Molecular Formula: C₁₁H₂₀O₄
• Molecular Weight: 216.27
• EINECS: 233-504-6
• Product Categories: Pharmaceutical Intermediates
• Mol File: 10203-58-4.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 110-112°C 10mm
• Flash Point: 225°C
• Appearance: /
• Density: 0,97 g/cm3
• Vapor Pressure: 0.0167mmHg at 25°C
• Refractive Index: 1.4220
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.01±0.46(Predicted)
• BRN: 1103030
• CAS DataBase Reference: Diethyl isobutylmalonate(CAS DataBase Reference)
• NIST Chemistry Reference: Diethyl isobutylmalonate(10203-58-4)
• EPA Substance Registry System: Diethyl isobutylmalonate(10203-58-4)

Safety Data

• Safety Statements: 24/25
• RTECS: TY1850200
• TSCA: Yes
• Hazardous Substances Data: 10203-58-4(Hazardous Substances Data)

Usage

Uses

Diethyl Isobutylmalonate is used as a reagent in the synthesis of quinoline-based zinc metallo-aminopeptidase inhibitors which have antimalarial activity.

InChI:InChI=1/C11H20O4/c1-5-14-10(12)9(7-8(3)4)11(13)15-6-2/h8-9H,5-7H2,1-4H3

Upstream product

• 996-82-7 sodium diethylmalonate 
• 513-38-2 Isobutyl iodide 
• 5256-74-6 1,3-diethyl 2-diazopropanedioate 
• 75-28-5 Isobutane 
• 5652-68-6 diethyl 2-(2-methylpropylidene)malonate 
• 96-10-6 diethylaluminium chloride 
• 105-53-3 diethyl malonate 
• 35227-78-2 diethyl (ethoxymagnesio)malonate 
• 563-43-9 ethylaluminum dichloride 
• 594-19-4 tert.-butyl lithium 
• 917-65-7 methylaluminum dichloride 
• 928-49-4 hex-3-yne 
• 109-72-8 n-butyllithium 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 91284-91-2 9-Phenyl-1,3-dimethyl-7-iso-butyl-6-hydroxy-9H-8-oxo-pyrimido[2,1-f]purine-2,4-dione 
• 39520-24-6 Isobutylmalonsaeure-dimethylester 
• 42846-91-3 (methyl-2 propyl)-5 barbiturique 
• 459164-66-0 2-(2-bromobenzyl)-4-methylpentanoic acid 
• 141-52-6 sodium ethanolate 
• 1168133-90-1 2-(4-amino-3-cyclopropylmethoxyphenyl)-4-methylpentanoic acid cyclopropylmethyl ester 
• 1168133-89-8 2-(3-cyclopropylmethoxy-4-nitrophenyl)-4-methylpentanoic acid cyclopropylmethyl ester 
• 1168133-88-7 2-(3-fluoro-4-nitrophenyl)-4-methylpentanoic acid ethyl ester 
• 1168133-87-6 2-(3-fluoro-4-nitrophenyl)-4-methylpentanoic acid 
• 1168114-17-7 2-(4-(benzo[c][1,2,5]oxadiazol-5-yl)-5-(cyclopropylmethoxy)-2-fluorophenyl)-4-methylpentanoic acid 
• 1168133-83-2 2-(4-cyclopropylmethoxy-3-iodo-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester 
• 1168133-82-1 2-(3-amino-4-cyclopropylmethoxy-5-trifluoromethylphenyl)-4-methylpentanoic acid ethyl ester 

Relevant articles and documents

FRUSTRATED LEWIS PAIR-IMPREGNATED POROUS MATERIALS AND USES THEREOF

Described herein are compositions composed of frustrated Lewis pairs impregnated in porous materials such as, for example, metal-organic frameworks, and their uses thereof. These compositions may allow new applications of frustrated Lewis pairs in catalysis by sequestering and protecting the frustrated Lewis pair within the nanospace of the porous material. Also provided are methods of hydrogenating an organic compound having at least one unsaturated functional group comprising using the compositions described herein.

Functional examination of novel kisspeptin phosphinic peptides

Kisspeptins acting on their cognate G protein-coupled receptor, kisspeptin receptor, play important roles in the suppression of cancer cell metastasis and regulation of the reproductive system, and therefore are important for therapeutic intervention. All native functional human kisspeptins (kisspeptin-54, kisspsptin-14 and kisspeptin-13) share the 10 amino acids of kisspeptin-10 at their C-terminus (45-54). However, they are inactivated rapidly by matrix metalloproteinases (MMPs) through the cleavage of the peptide bond between glycine 51 and leucine52, which limits their clinical applications. Development of MMP-resistant analogues of kisspeptins may provide better therapeutic outputs. In the present study, two kisspeptin phosphinic peptides were designed and synthesized, and their ability to induce phosphorylation of ERK1/2 through kisspeptin receptor and their inhibition on MMP-2 and MMP-9 whose activity correlates with cancer metastasis were assessed. The results showed that one analogue, phosphinic kisspeptin R isomer (PKPR), exhibited kisspeptin receptor-agonistic activity and also inhibitory activity on MMP-2, indicating that PKPR may serve as a lead for the further development of kisspeptin analogues for therapeutic purpose.

A amide alkaloid fully synthetic method

The invention discloses a total synthesis method of amides alkaloid, and belongs to the technical field of the chemistry of natural products. The total synthesis method comprises the following steps: carrying out the synthesis by adopting malonate and 2-bromopropane or 2-bromopropane derivative as raw materials, thereby obtaining isopropyl malonate; (2) carrying out the synthesis by adopting 2-aminopyrrolidine as a raw material, thereby obtaining mid-body 2-amino tetralin pyrrolidine; and (3) synthesizing amides alkaloid 3-isopropyl-nafoxidine[1,2-alpha]pyrimidine-2,4(1H,3H)-diketone and a derivative by adopting the isopropyl malonate and the 2-2-amino tetralin pyrrolidine as a raw material. By adopting the total synthesis method, the defect that the extraction separation process in the natural product is complicated and the yield is low can be overcome, and the demand of perople for further researching the natural product can be satisfied; moreover, the synthesis method is simple in route, raw materials are cheap and easy to obtain, and the yield is relatively high.