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1020575-47-6

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1020575-47-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1020575-47-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,0,5,7 and 5 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1020575-47:
(9*1)+(8*0)+(7*2)+(6*0)+(5*5)+(4*7)+(3*5)+(2*4)+(1*7)=106
106 % 10 = 6
So 1020575-47-6 is a valid CAS Registry Number.

1020575-47-6Relevant articles and documents

Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene

Bass, Jonathan Y.,Caravella, Justin A.,Chen, Lihong,Creech, Katrina L.,Deaton, David N.,Madauss, Kevin P.,Marr, Harry B.,McFadyen, Robert B.,Miller, Aaron B.,Mills, Wendy Y.,Navas III, Frank,Parks, Derek J.,Smalley Jr., Terrence L.,Spearing, Paul K.,Todd, Dan,Williams, Shawn P.,Wisely, G. Bruce

supporting information; experimental part, p. 1206 - 1213 (2011/04/16)

To improve on the drug properties of GSK8062 1b, a series of heteroaryl bicyclic naphthalene replacements were prepared. The quinoline 1c was an equipotent FXR agonist with improved drug developability parameters relative to 1b. In addition, analog 1c lowered body weight gain and serum glucose in a DIO mouse model of diabetes.

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