1026305-95-2

Basic information

• Product Name: Methanesulfonic acid (2S,3S,4S,4aR,8aS)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,4a,8,8-tetramethyl-decahydro-naphthalen-2-yl ester
• Synonyms: Methanesulfonic acid (2S,3S,4S,4aR,8aS)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,4a,8,8-tetramethyl-decahydro-naphthalen-2-yl ester
• CAS NO: 1026305-95-2
• Molecular Weight: 570.909
• Mol File: 1026305-95-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Methanesulfonic acid (2S,3S,4S,4aR,8aS)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,4a,8,8-tetramethyl-decahydro-naphthalen-2-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonic acid (2S,3S,4S,4aR,8aS)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,4a,8,8-tetramethyl-decahydro-naphthalen-2-yl ester(1026305-95-2)
• EPA Substance Registry System: Methanesulfonic acid (2S,3S,4S,4aR,8aS)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,4a,8,8-tetramethyl-decahydro-naphthalen-2-yl ester(1026305-95-2)

Safety Data

• Hazardous Substances Data: 1026305-95-2(Hazardous Substances Data)

Upstream product

• 378197-93-4 (4aS,8aS,2R,4R)-4-(2-[tert-butyldiphenylsilyloxy]ethyl)-4a,8,8,trimethyl-3-methyleneperhydro-2-naphthalenol 
• 378197-91-2 (4aS,8aS,1R,2R)-1-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,5,5,8a-tetramethylperhydro-2-naphthalenol 
• 378197-94-5 (2R,4S,4aR,8aS)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3,4a,8,8-tetramethyl-decahydro-naphthalen-2-ol 
• 378197-95-6 (3S,4S,8aS,4aR)-4-(2-(tert-butyldiphenylsilyloxy)ethyl)-3,4a,8,8-tetramethylperhydro-2-naphthalenone 
• 564-20-5 (3aR)-(+)-sclareolide 
• 38419-75-9 (1R,2R,4aS,8aS)-1-(2-hydroxyethyl)-2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 378198-07-3 [(E)-(1R,2R)-4-Benzenesulfonyl-8-(2,5-bis-benzyloxy-phenyl)-2,6-dimethyl-1-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-oct-6-enyloxy]-tert-butyl-dimethyl-silane 
• 378198-08-4 (2R,3R,7E)-2-(tert-butyldimethylsiliyloxy)-9-(2,5-dibenzyloxyphenyl)-3,7-dimethyl-1-[(1S,4aS,8aS)-1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl-1-naphthalenyl]-7-nonene 
• 378198-09-5 (2R,3R,7E)-9-(2,5-dibenzyloxyphenyl)-3,7-dimethyl-1-[(1S,4aS,8aS)-1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl-1-naphthalenyl]-7-nonen-2-ol 
• 378198-10-8 (2R,3R,7E)-9-(2,5-dihydroxyphenyl)-3,7-dimethyl-1-[(1S,4aS,8aS)-1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl-1-naphthalenyl]-7-nonen-2-ol 
• 1026602-48-1 2-[(E)-(7R,8R)-8-Hydroxy-3,7-dimethyl-9-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl)-non-2-enyl]-[1,4]benzoquinone 
• 378198-02-8 [(E)-(1R,2R)-4-Benzenesulfonyl-2-methyl-1-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-but-3-enyloxy]-tert-butyl-dimethyl-silane 
• 378198-03-9 [(1R,2R)-4-Benzenesulfonyl-2-methyl-1-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-butoxy]-tert-butyl-dimethyl-silane 
• 378197-98-9 (2S,3R)-1-[(4S)-4-benzyl-2-oxo-1,3-oxazolan-3-yl]-3-hydroxy-2-methyl-4-[(1S,4aS,8aS)-1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl-1-naphthalenyl]butan-1-one 
• 116163-52-1 2-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)acetaldehyde 
• 378197-96-7 tert-Butyl-diphenyl-[2-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl)-ethoxy]-silane 

Relevant articles and documents

Total synthesis and determination of the absolute configuration of coscinosulfate. A new selective inhibitor of Cdc25 protein phosphatase

The first total synthesis of coscinosulfate 1, a metabolite isolated from a sea sponge, starting from (+)-sclareolide 3 is described. The convergent synthesis strategy relies on the coupling of sulfone 21 with the bromide 26. The sulfone fragment 21 was obtained by successive asymmetric aldol reaction with aldehyde 2 to introduce the stereocenters at C-12 and C-13, followed by one-carbon homologation via Horner - Wadsworth - Emmons olefination. The selective sulfatation at C-12 was accomplished through the quinone intermediate 31 obtained by selective oxidation of hydroquinone 30 this, when followed by reduction, furnished the desired coscinosulfate 1. X-ray analysis of the intermediate aldehyde 18 confirmed the proposed stucture.