1026744-80-8Relevant articles and documents
Nonpeptidic inhibitors of human neutrophil elastase. 7. Design, synthesis, and in vitro activity of a series of pyridopyrimidine trifluoromethyl ketones
Edwards, Philip D.,Andisik, Donald W.,Strimpler, Anne M.,Gomes, Bruce,Tuthill, Paul A.
, p. 1112 - 1124 (2007/10/03)
Using molecular modeling and the information derived from X-ray crystal structures of human neutrophil elastase (HNE) and porcine pancreatic elastase (PPE) complexed to peptidic ligands, we have developed a new series of nonpeptidic inhibitors of HNE, the