103280-96-2

Basic information

• Product Name: 2,2'-(2-(p-tolyl)propane-1,3-diyl)diquinoline
• Synonyms: 2,2'-(2-(p-tolyl)propane-1,3-diyl)diquinoline
• CAS NO: 103280-96-2
• Molecular Weight: 388.512
• Mol File: 103280-96-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,2'-(2-(p-tolyl)propane-1,3-diyl)diquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-(2-(p-tolyl)propane-1,3-diyl)diquinoline(103280-96-2)
• EPA Substance Registry System: 2,2'-(2-(p-tolyl)propane-1,3-diyl)diquinoline(103280-96-2)

Safety Data

• Hazardous Substances Data: 103280-96-2(Hazardous Substances Data)

Upstream product

• 58702-62-8 2-[(1E)-2-(4-methylphenyl)ethenyl]quinoline 
• 91-63-4 2-methylquinoline 
• 104-87-0 4-methyl-benzaldehyde 

Relevant articles and documents

C(sp3)-H functionalization of methyl azaarenes: a calcium-catalyzed facile synthesis of (E)-2-styryl azaarenes and 2-aryl-1,3-bisazaarenes

Alkaline earth (Ca2+) catalyzed sp3 C-H functionalization of methyl azaarenes for the synthesis of biologically important (E)-2-styryl azaarenes, 2-aryl-1,3-bisazaarenes and 3,3-bisazaarenyl indolinones has been described. Initially methyl azaarenes react with aryl aldehydes to give β-hydroxy derivatives, which undergo Ca(II) catalyzed thermodynamic elimination to give the styryl azaarenes in a single step. Similarly it may undergo SN1 reaction to give 2-aryl-1,3-bisazaarenes and 3,3-bisazaarenyl indolinones (if isatin used as the electrophile). This green synthetic methodology enjoys the simple reaction procedures, solvent free conditions, step economy, substrate diversity and high yields of the products in short time.