10329-98-3Relevant articles and documents
Acceptor substrate-based selective inhibition of galactosyltransferases
Chung, Sang J.,Takayama, Shuichi,Wong, Chi-Huey
, p. 3359 - 3364 (1998)
This paper describes the discovery of glycosyl acceptor analogs as potent and selective inhibitors of α-1,3- and β-1,4- galactosyltransferases. Incorporation of an appropriate aromatic group to the aglycon position of the enzyme's acceptors results in a strong inhibition, representing the first and most potent small uncharged molecules as selective inhibitors of these two enzymes and thus providing a new strategy for the development of selective glycosyltransferase inhibitors.
