1032903-64-2

Basic information

• Product Name: 4-[4-[[5-Chloro-4-[[2-[(propan-2-yl)sulfonyl]phenyl]amino]pyrimidin-2-yl]amino]-5-isopropoxy-2-methylphenyl]piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-[4-[[5-Chloro-4-[[2-[(propan-2-yl)sulfonyl]phenyl]amino]pyrimidin-2-yl]amino]-5-isopropoxy-2-methylphenyl]piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 4-(4-(5-chloro-4-(2-(isopropylsulfonyl)phenylamino)pyrimidin-2-ylamino)-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate
• CAS NO: 1032903-64-2
• Molecular Formula: C₃₃H₄₄ClN₅O₅S
• Molecular Weight: 658.25
• Mol File: 1032903-64-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[4-[[5-Chloro-4-[[2-[(propan-2-yl)sulfonyl]phenyl]amino]pyrimidin-2-yl]amino]-5-isopropoxy-2-methylphenyl]piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-[[5-Chloro-4-[[2-[(propan-2-yl)sulfonyl]phenyl]amino]pyrimidin-2-yl]amino]-5-isopropoxy-2-methylphenyl]piperidine-1-carboxylic acid tert-butyl ester(1032903-64-2)
• EPA Substance Registry System: 4-[4-[[5-Chloro-4-[[2-[(propan-2-yl)sulfonyl]phenyl]amino]pyrimidin-2-yl]amino]-5-isopropoxy-2-methylphenyl]piperidine-1-carboxylic acid tert-butyl ester(1032903-64-2)

Safety Data

• Hazardous Substances Data: 1032903-64-2(Hazardous Substances Data)

Usage

General Description

The chemical "4-[4-[[5-Chloro-4-[[2-[(propan-2-yl)sulfonyl]phenyl]amino]pyrimidin-2-yl]amino]-5-isopropoxy-2-methylphenyl]piperidine-1-carboxylic acid tert-butyl ester" is a complex compound with a piperidine structure and multiple functional groups including a carboxylic acid, tert-butyl ester, sulfonyl, and chloro-substituted phenyl rings. This chemical may have potential pharmaceutical or medicinal applications due to its structural features, and it is likely to be used in research and development for new drug candidates. The precise properties and characteristics of this chemical would need to be further investigated through experimentation and analysis to fully understand its potential applications.

Upstream product

• 112108-73-3 1-chloro-5-fluoro-2-methyl-4-nitrobenzene 
• 1032903-50-6 1-chloro-2-methyl-4-nitro-5-(propan-2-yloxy)benzene 
• 1032903-62-0 4-[2-methyl-4-nitro-5-(propan-2-yloxy)phenyl]pyridine 
• 76697-50-2 1-amino-2-(isopropylsulphonyl)benzene 
• 452-73-3 2-chloro-4-fluorotoluene 
• 1035230-24-0 5-chloro-N²-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N⁴-((2-isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 
• 1032903-63-1 4-(4-amino-5-isopropoxy-2-methylphenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 70415-86-0 1-(isopropylsulfonyl)-2-nitrobenzene 
• 70415-85-9 2-(isopropyl sulfanyl)nitrobenzene 
• 1493-27-2 ortho-nitrofluorobenzene 
• 1202858-68-1 1-bromo-5-isopropoxy-2-methyl-4-nitrobenzene 
• 1254062-68-4 2-bromo-4-isopropoxy-1-methylbenzene 
• 60710-39-6 3-bromo-p-cresol 
• 1032903-52-8 4-(2-methyl-4-nitro-5-isopropoxyphenyl)-5,6-dihydropyridine-1(2H)-carboxylic acid tert-butyl ester 

Downstream Products

• 1380575-43-8 ceritinib hydrochloride 
• 1380575-43-8 5-chloro-N²-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N⁴-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine hydrochloride 
• 1445895-03-3 5-chloro-N₂-(2-isopropoxy-5-methyl-4-(1-ethylpiperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 
• 1445895-04-4 5-chloro-N₂-(2-isopropoxy-5-methyl-4-(1-isopropylpiperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 
• 1445895-08-8 5-chloro-N₂-(4-(1-(2,2-difluoroethyl)piperidin-4-yl)-2-isopropoxy-5-methylphenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 
• 1190399-47-3 1-(4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)-2-(dimethylamino)ethanone 
• 1032900-25-6 5-chloro-N²-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N⁴-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine 

Relevant articles and documents

Preparation method of ceritinib and key intermediate thereof

The invention discloses a preparation method of ceritinib and a key intermediate thereof and belongs to the field of medicinal chemistry. The purity of a final product is high and reaches 99.7 percentand the yield is high and reaches 92.7 percent; the preparation method is simple to operate and column chromatography is not needed; furthermore, first-step reaction selectively acts on specific chlorine atoms on pyrimidine and NH in a compound 2 is protected so that side effects are few, requirements on reaction conditions are relatively low, the yield is high, the purity is high and the post-treatment is simple; industrial production is easy to realize.

Novel kinase inhibitors

The present invention relates to a novel kinase inhibitor useful as a medicine for tumor, nerve disorder and mental illness. The purpose of the present invention is to provide a compound having improved blood-aqueous barrier penetrability to neurodegenerative diseases that cancer spreads to brain or progresses in brain. To this end, provided is a compound represented by chemical formula 1 or a pharmaceutically allowable salt thereof.COPYRIGHT KIPO 2017

Method for preparing ALK inhibitor ceritinib

Embodiment of present disclosure provides a method for preparing ceritinib of formula I, comprising: (1) contacting a compound of formula 12b with an amino protective group to obtain a compound of formula 3; (2) contacting the compound of formula 3 with a compound of formula 9a to obtain a compound of formula 5; and (3) subjecting the compound of formula 5 to a deprotection reaction to obtain the ceritinib of formula I. Then ceritinib may be effectively prepared.